X0306 4 2018-03-02 0 0001496671 Calithera Biosciences, Inc. CALA 0001553389 Molineaux Susan C/O CALITHERA BIOSCIENCES, INC. 343 OYSTER POINT BLVD. #200 SOUTH SAN FRANCISCO CA 94080 1 1 0 0 PRESIDENT AND CEO Common Stock 2018-03-02 4 M 0 26992 2.64 A 44860 D Common Stock 349190 I By Trust Common Stock 21000 I By Spouse Employee Stock Option (Right to Buy) 2.64 2018-03-02 4 M 0 26992 0.00 D 2023-12-16 Common Stock 26992 9729 D Employee Stock Option (Right to Buy) 2.64 2018-03-02 4 M 0 6798 0.00 D 2023-12-16 Common Stock 6798 0 I By Spouse Includes 2,500 shares acquired under the Company's 2014 Employee Stock Purchase Plan on December 8, 2017. Shares are held by the Molineaux Family Trust, of which the Reporting Person is a Trustee. 1/48 of the Option vests in equal monthly installments one month from 12/17/2013. The option shall be subject to accelerated vesting as set forth in the optionee's employment agreement with the Company. /s/ Susan M. Molineaux 2018-03-06