Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (59,309)	$ (51,894)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	1,664	1,224
Stock-based compensation expense	11,047	11,499
Purchase of net discount (premium) on marketable securities	1,705	(20)
Net (accretion of discount) amortization of premiums on marketable securities	(2,487)	165
Non-cash lease expense	1,323	1,001
Changes in assets and liabilities:
Prepaid expenses and other current assets	(58)	933
Other non-current assets	(154)	29
Accounts payable	1,604	(1,244)
Accrued liabilities	(5,102)	362
Lease liabilities, net	(708)	(944)
Deferred Revenue	(522)	0
Net cash used in operating activities	(50,997)	(38,889)
Cash flows from investing activities:
Purchase of property, plant and equipment	(3,937)	(2,977)
Purchases of marketable securities	(89,274)	(40,126)
Proceeds from maturities of marketable securities	163,035	24,000
Net cash provided by (used in) investing activities	69,824	(19,103)
Cash flows from financing activities:
Proceeds from exercise of stock options	75	133
Payment of deferred offering costs	0	(61)
Net cash provided by financing activities	75	72
Net increase (decrease) in cash, cash equivalents, and restricted cash	18,902	(57,920)
Beginning of period	121,920	134,035
End of period	140,822	76,115
Cash and cash equivalents	140,164	75,417
Restricted cash	658	698
Cash, cash equivalents, and restricted cash	140,822	76,115
Supplemental disclosure of non-cash investing and financing activities:
Right-of-use assets recognized in exchange for lease obligations	830	2,093
Unpaid amounts related to purchase of property, plant and equipment	2,439	231
Unpaid amounts related to offering costs for public offering	$ 0	$ 460