The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   6,580,377 30,256 SH   DFND 1,2 30,256 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   5,703,057 256,202 SH   DFND 1,2 256,202 0 0
ALPHA COGNITION INC COM NEW 02074J501   3,116,212 567,616 SH   DFND 1,2 567,616 0 0
AMAZON COM INC COM 023135106   6,652,144 31,940 SH   DFND   31,940 0 0
AMGEN INC COM 031162100   2,638,875 7,500 SH   DFND 1,2 7,500 0 0
AMICUS THERAPEUTIC COM 03152W109   8,724,831 603,377 SH   DFND 1,2 603,377 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   8,645,990 214,914 SH   DFND 1,2 214,914 0 0
APPLIED OPTOELECTRONICS INC COM 03823U102   6,208,906 73,400 SH   DFND   73,400 0 0
APREA THERAPEUTICS INC COM NEW 03836J201   205,983 270,000 SH   DFND 1,2 270,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   1,829,840 8,000 SH   DFND 1,2 8,000 0 0
ASTRAZENECA PLC ORD G0593M107   12,332,167 62,530 SH   DFND 1,2 62,530 0 0
BIOAGE LABS INC COM 09077V100   1,513,200 86,518 SH   DFND 1,2 86,518 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   8,248,737 866,464 SH   DFND 1,2 866,464 0 0
BIOGEN INC COM 09062X103   16,962,792 92,526 SH   DFND 1,2 92,526 0 0
BIOHAVEN LTD COM G1110E107   5,025,240 594,000 SH   DFND 1,2 594,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   7,902,951 139,900 SH   DFND 1,2 139,900 0 0
BRIDGEBIO PHARMA INC COM 10806X102   18,211,968 245,246 SH   DFND 1,2 245,246 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   1,061,375 17,500 SH   DFND 1,2 17,500 0 0
CAMTEK LTD ORD M20791105   8,038,362 53,020 SH   DFND   53,020 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   7,726,199 243,575 SH   DFND 1,2 243,575 0 0
CELLEBRITE DI LTD ORDINARY SHARES M2197Q107   8,702,359 631,521 SH   DFND   631,521 0 0
CLIMB BIO INC COM 28658R106   2,871,842 419,247 SH   DFND 1,2 419,247 0 0
COGENT BIOSCIENCES INC COM 19240Q201   16,024,927 416,340 SH   DFND 1,2 416,340 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100   2,265,584 173,475 SH   DFND 1,2 173,475 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   3,627,669 247,961 SH   DFND 1,2 247,961 0 0
CURIS INC COM 231269309   1,091,829 1,994,937 SH   DFND 1,2 1,994,937 0 0
CYBIN INC COM NEW 23256X407   4,738,032 987,090 SH   DFND 1,2 987,090 0 0
CYTOKINETICS INC COM NEW 23282W605   2,624,338 39,817 SH   DFND 1,2 39,817 0 0
CYTOKINETICS INC COM NEW 23282W605   17,090,464 259,300 SH Call DFND 1,2 0 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105   1,034,000 220,000 SH   DFND 1,2 220,000 0 0
DISC MEDICINE INC COM 254604101   3,423,220 53,538 SH   DFND 1,2 53,538 0 0
DYNE THERAPEUTICS INC COM 26818M108   2,911,569 160,594 SH   DFND 1,2 160,594 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101   5,458,163 1,772,131 SH   DFND 1,2 1,772,131 0 0
ELI LILLY & CO COM 532457108   8,314,721 9,040 SH   DFND 1,2 9,040 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   6,007,988 153,265 SH   DFND 1,2 153,265 0 0
ENPHASE ENERGY INC COM 29355A107   5,384,862 142,419 SH   DFND   142,419 0 0
EVOMMUNE INC COM SHS 30054Y107   1,798,600 78,234 SH   DFND 1,2 78,234 0 0
FOGHORN THERAPEUTICS INC COM 344174107   58,431 12,224 SH   DFND 1,2 12,224 0 0
FORTE BIOSCIENCES INC COM NEW 34962G208   4,791,086 184,984 SH   DFND 1,2 184,984 0 0
GENERATE BIOMEDICINES INC COM SHS 370920100   2,312,500 185,000 SH   DFND 1,2 185,000 0 0
GSK PLC SPONSORED ADR 37733W204   6,733,180 122,000 SH   DFND 1,2 122,000 0 0
IMMATICS N.V SHS N44445109   6,849,673 696,105 SH   DFND 1,2 696,105 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101   2,286,182 59,505 SH   DFND   59,505 0 0
ISHARES TR 20 YR TR BD ETF 464287432   4,074,430 47,000 SH Call DFND   0 0 0
JOHNSON & JOHNSON COM 478160104   7,047,450 28,831 SH   DFND 1,2 28,831 0 0
KODIAK SCIENCES INC COM 50015M109   4,376,024 114,796 SH   DFND 1,2 114,796 0 0
KURA ONCOLOGY INC COM 50127T109   2,402,594 295,522 SH   DFND 1,2 295,522 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   4,732,169 9,040 SH   DFND 1,2 9,040 0 0
MAZE THERAPEUTICS INC COM 578784100   6,786,189 227,343 SH   DFND 1,2 227,343 0 0
MEDIWOUND LTD SHS NEW M68830112   4,401,123 273,192 SH   DFND 1,2 273,192 0 0
MERCK & CO INC COM 58933Y105   5,846,094 48,600 SH   DFND 1,2 48,600 0 0
MINERALYS THERAPEUTICS INC COM 603170101   36,299,814 1,339,971 SH   DFND 1,2 1,339,971 0 0
NICE LTD SPONSORED ADR 653656108   618,669 5,611 SH   DFND   5,611 0 0
NOVA LTD COM M7516K103   23,175,786 53,366 SH   DFND   53,366 0 0
NOVARTIS AG SPONSORED ADR 66987V109   5,651,750 37,000 SH   DFND 1,2 37,000 0 0
NOVO-NORDISK A S ADR 670100205   4,434,880 120,677 SH   DFND 1,2 120,677 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   1,491,000 100,000 SH Call DFND 1,2 0 0 0
ORGANOGENESIS HLDGS INC COM 68621F102   1,303,500 550,000 SH   DFND 1,2 550,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   6,811,747 537,628 SH   DFND 1,2 537,628 0 0
ORMAT TECHNOLOGIES INC COM 686688102   7,638,540 68,250 SH   DFND   68,250 0 0
OVID THERAPEUTICS INC COM 690469101   3,602,678 1,622,828 SH   DFND 1,2 1,622,828 0 0
PALISADE BIO INC COM 696389402   3,033,574 1,733,471 SH   DFND 1,2 1,733,471 0 0
PALO ALTO NETWORKS INC COM 697435105   8,464,896 52,800 SH   DFND   52,800 0 0
PFIZER INC COM 717081103   5,222,880 186,000 SH   DFND 1,2 186,000 0 0
PRECISION BIOSCIENCES INC COM NEW 74019P207   220,000 40,000 SH   DFND 1,2 40,000 0 0
PRELUDE THERAPEUTICS INC COM 74065P101   1,909,519 558,339 SH   DFND 1,2 558,339 0 0
PROMIS NEUROSCIENCES INC COM SHS 74346M505   4,135,012 325,591 SH   DFND 1,2 325,591 0 0
RELAY THERAPEUTICS INC COM 75943R102   4,063,938 408,436 SH   DFND 1,2 408,436 0 0
REVOLUTION MEDICINES INC COM 76155X100   5,359,448 55,110 SH   DFND 1,2 55,110 0 0
SANOFI SA SPONSORED ADR 80105N105   12,985,233 269,515 SH   DFND 1,2 269,515 0 0
SATELLOS BIOSCIENCE INC COM 80401L803   2,754,235 489,207 SH   DFND 1,2 489,207 0 0
SAVARA INC COM 805111101   4,035,835 739,164 SH   DFND 1,2 739,164 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   4,634,067 94,265 SH   DFND 1,2 94,265 0 0
SHATTUCK LABS INC COM 82024L103   1,805,454 280,786 SH   DFND 1,2 280,786 0 0
SKYE BIOSCIENCE INC COM NEW 83086J200   417,269 678,928 SH   DFND 1,2 678,928 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   2,697,278 52,836 SH   DFND   52,836 0 0
SOLAREDGE TECHNOLOGIES INC NOTE 2.250% 7/0 83417MAE4   6,909,620 4,000,000 SH   DFND   4,000,000 0 0
SOLENO THERAPEUTICS INC COM 834203309   7,241,088 216,281 SH   DFND 1,2 216,281 0 0
SPDR SERIES TRUST STATE STREET SPD 78464A870   25,546,001 200,000 SH Put DFND 1,2 200,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   2,448,560 50,800 SH   DFND 1,2 50,800 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   16,925,792 724,563 SH   DFND 1,2 724,563 0 0
TANGO THERAPEUTICS INC COM 87583X109   7,187,338 343,563 SH   DFND 1,2 343,563 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605   2,174,880 136,015 SH   DFND 1,2 136,015 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   31,534,887 1,046,975 SH   DFND   1,046,975 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   2,710,800 90,000 SH   DFND 1,2 90,000 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   25,573,578 145,735 SH   DFND   145,735 0 0
TREVI THERAPEUTICS INC COM 89532M101   6,848,166 574,029 SH   DFND 1,2 574,029 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   16,955,526 809,333 SH   DFND 1,2 809,333 0 0
UPSTREAM BIO INC COM 91678A107   3,222,000 358,000 SH   DFND 1,2 358,000 0 0
VERASTEM INC COM NEW 92337C203   1,821,493 343,678 SH   DFND 1,2 343,678 0 0
VOR BIOPHARMA INC COM NEW 929033207   5,742,999 321,917 SH   DFND 1,2 321,917 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   1,813,277 469,761 SH   DFND 1,2 469,761 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   3,974,972 548,272 SH   DFND 1,2 548,272 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   521,882 626,810 SH   DFND 1,2 626,810 0 0
XENON PHARMACEUTICALS INC COM 98420N105   7,385,050 127,000 SH   DFND 1,2 127,000 0 0
ZENAS BIOPHARMA INC COM 98937L105   4,190,230 214,334 SH   DFND 1,2 214,334 0 0
ZIM INTEGRATED SHIPPING SERV SHS M9T951109   2,791,783 105,950 SH   DFND   105,950 0 0