0001496201-26-000003.txt : 20260515
0001496201-26-000003.hdr.sgml : 20260515
20260515151908
ACCESSION NUMBER: 0001496201-26-000003
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20260331
FILED AS OF DATE: 20260515
DATE AS OF CHANGE: 20260515
EFFECTIVENESS DATE: 20260515
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
ORGANIZATION NAME:
EIN: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 26986148
BUSINESS ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
13F-HR
1
primary_doc.xml
X0202
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
03-31-2026
03-31-2026
SPHERA FUNDS MANAGEMENT LTD.
4 ITZHAK SADE BUILDING A
29TH FLOOR
TEL AVIV
L3
6777520
13F HOLDINGS REPORT
028-15863
000312614
802-120694
Y
Investment discretion with regard to a portion of the securities reported herein exercised by Sphera Portfolio Management Ltd, which is wholly owned by Sphera Funds Management Ltd. Per guidance received from the Division of Investment Management, since Sphera Portfolio Management Ltd does not meet the Section 13(f) securities threshold, its holdings are aggregated with those reported for Sphera Funds Management Ltd. Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, Sphera Portfolio Management, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, Sphera Portfolio Management, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S..
Oshrat Levi
Chief Financial Officer
972 3 6845617
Oshrat Levi
Tel Aviv
L3
05-15-2026
2
97
629683422
false
1
0001599854
028-15865
000172608
802-127045
Sphera Global Healthcare Management LP
2
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
INFORMATION TABLE
2
sphera13fq1.xml
ABBVIE INC
COM
00287Y109
6580377
30256
SH
DFND
1,2
30256
0
0
ACADIA PHARMACEUTICALS INC
COM
004225108
5703057
256202
SH
DFND
1,2
256202
0
0
ALPHA COGNITION INC
COM NEW
02074J501
3116212
567616
SH
DFND
1,2
567616
0
0
AMAZON COM INC
COM
023135106
6652144
31940
SH
DFND
31940
0
0
AMGEN INC
COM
031162100
2638875
7500
SH
DFND
1,2
7500
0
0
AMICUS THERAPEUTIC
COM
03152W109
8724831
603377
SH
DFND
1,2
603377
0
0
APELLIS PHARMACEUTICALS INC
COM
03753U106
8645990
214914
SH
DFND
1,2
214914
0
0
APPLIED OPTOELECTRONICS INC
COM
03823U102
6208906
73400
SH
DFND
73400
0
0
APREA THERAPEUTICS INC
COM NEW
03836J201
205983
270000
SH
DFND
1,2
270000
0
0
ASCENDIS PHARMA A/S
SPONSORED ADR
04351P101
1829840
8000
SH
DFND
1,2
8000
0
0
ASTRAZENECA PLC
ORD
G0593M107
12332167
62530
SH
DFND
1,2
62530
0
0
BIOAGE LABS INC
COM
09077V100
1513200
86518
SH
DFND
1,2
86518
0
0
BIOCRYST PHARMACEUTICALS INC
COM
09058V103
8248737
866464
SH
DFND
1,2
866464
0
0
BIOGEN INC
COM
09062X103
16962792
92526
SH
DFND
1,2
92526
0
0
BIOHAVEN LTD
COM
G1110E107
5025240
594000
SH
DFND
1,2
594000
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
7902951
139900
SH
DFND
1,2
139900
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
18211968
245246
SH
DFND
1,2
245246
0
0
BRISTOL-MYERS SQUIBB CO
COM
110122108
1061375
17500
SH
DFND
1,2
17500
0
0
CAMTEK LTD
ORD
M20791105
8038362
53020
SH
DFND
53020
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
7726199
243575
SH
DFND
1,2
243575
0
0
CELLEBRITE DI LTD
ORDINARY SHARES
M2197Q107
8702359
631521
SH
DFND
631521
0
0
CLIMB BIO INC
COM
28658R106
2871842
419247
SH
DFND
1,2
419247
0
0
COGENT BIOSCIENCES INC
COM
19240Q201
16024927
416340
SH
DFND
1,2
416340
0
0
CONTINEUM THERAPEUTICS INC
CL A
21217B100
2265584
173475
SH
DFND
1,2
173475
0
0
CORVUS PHARMACEUTICALS INC
COM
221015100
3627669
247961
SH
DFND
1,2
247961
0
0
CURIS INC
COM
231269309
1091829
1994937
SH
DFND
1,2
1994937
0
0
CYBIN INC
COM NEW
23256X407
4738032
987090
SH
DFND
1,2
987090
0
0
CYTOKINETICS INC
COM NEW
23282W605
2624338
39817
SH
DFND
1,2
39817
0
0
CYTOKINETICS INC
COM NEW
23282W605
17090464
259300
SH
Call
DFND
1,2
0
0
0
CYTOMX THERAPEUTICS INC.
COM
23284F105
1034000
220000
SH
DFND
1,2
220000
0
0
DISC MEDICINE INC
COM
254604101
3423220
53538
SH
DFND
1,2
53538
0
0
DYNE THERAPEUTICS INC
COM
26818M108
2911569
160594
SH
DFND
1,2
160594
0
0
ELEDON PHARMACEUTICALS INC
COM
28617K101
5458163
1772131
SH
DFND
1,2
1772131
0
0
ELI LILLY & CO
COM
532457108
8314721
9040
SH
DFND
1,2
9040
0
0
ENLIVEN THERAPEUTICS INC
COM
29337E102
6007988
153265
SH
DFND
1,2
153265
0
0
ENPHASE ENERGY INC
COM
29355A107
5384862
142419
SH
DFND
142419
0
0
EVOMMUNE INC
COM SHS
30054Y107
1798600
78234
SH
DFND
1,2
78234
0
0
FOGHORN THERAPEUTICS INC
COM
344174107
58431
12224
SH
DFND
1,2
12224
0
0
FORTE BIOSCIENCES INC
COM NEW
34962G208
4791086
184984
SH
DFND
1,2
184984
0
0
GENERATE BIOMEDICINES INC
COM SHS
370920100
2312500
185000
SH
DFND
1,2
185000
0
0
GSK PLC
SPONSORED ADR
37733W204
6733180
122000
SH
DFND
1,2
122000
0
0
IMMATICS N.V
SHS
N44445109
6849673
696105
SH
DFND
1,2
696105
0
0
ISHARES BITCOIN TRUST ETF
SHS BEN INT
46438F101
2286182
59505
SH
DFND
59505
0
0
ISHARES TR
20 YR TR BD ETF
464287432
4074430
47000
SH
Call
DFND
0
0
0
JOHNSON & JOHNSON
COM
478160104
7047450
28831
SH
DFND
1,2
28831
0
0
KODIAK SCIENCES INC
COM
50015M109
4376024
114796
SH
DFND
1,2
114796
0
0
KURA ONCOLOGY INC
COM
50127T109
2402594
295522
SH
DFND
1,2
295522
0
0
MADRIGAL PHARMACEUTICALS INC
COM
558868105
4732169
9040
SH
DFND
1,2
9040
0
0
MAZE THERAPEUTICS INC
COM
578784100
6786189
227343
SH
DFND
1,2
227343
0
0
MEDIWOUND LTD
SHS NEW
M68830112
4401123
273192
SH
DFND
1,2
273192
0
0
MERCK & CO INC
COM
58933Y105
5846094
48600
SH
DFND
1,2
48600
0
0
MINERALYS THERAPEUTICS INC
COM
603170101
36299814
1339971
SH
DFND
1,2
1339971
0
0
NICE LTD
SPONSORED ADR
653656108
618669
5611
SH
DFND
5611
0
0
NOVA LTD
COM
M7516K103
23175786
53366
SH
DFND
53366
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
5651750
37000
SH
DFND
1,2
37000
0
0
NOVO-NORDISK A S
ADR
670100205
4434880
120677
SH
DFND
1,2
120677
0
0
OLEMA PHARMACEUTICALS INC
COM
68062P106
1491000
100000
SH
Call
DFND
1,2
0
0
0
ORGANOGENESIS HLDGS INC
COM
68621F102
1303500
550000
SH
DFND
1,2
550000
0
0
ORIC PHARMACEUTICALS INC
COM
68622P109
6811747
537628
SH
DFND
1,2
537628
0
0
ORMAT TECHNOLOGIES INC
COM
686688102
7638540
68250
SH
DFND
68250
0
0
OVID THERAPEUTICS INC
COM
690469101
3602678
1622828
SH
DFND
1,2
1622828
0
0
PALISADE BIO INC
COM
696389402
3033574
1733471
SH
DFND
1,2
1733471
0
0
PALO ALTO NETWORKS INC
COM
697435105
8464896
52800
SH
DFND
52800
0
0
PFIZER INC
COM
717081103
5222880
186000
SH
DFND
1,2
186000
0
0
PRECISION BIOSCIENCES INC
COM NEW
74019P207
220000
40000
SH
DFND
1,2
40000
0
0
PRELUDE THERAPEUTICS INC
COM
74065P101
1909519
558339
SH
DFND
1,2
558339
0
0
PROMIS NEUROSCIENCES INC
COM SHS
74346M505
4135012
325591
SH
DFND
1,2
325591
0
0
RELAY THERAPEUTICS INC
COM
75943R102
4063938
408436
SH
DFND
1,2
408436
0
0
REVOLUTION MEDICINES INC
COM
76155X100
5359448
55110
SH
DFND
1,2
55110
0
0
SANOFI SA
SPONSORED ADR
80105N105
12985233
269515
SH
DFND
1,2
269515
0
0
SATELLOS BIOSCIENCE INC
COM
80401L803
2754235
489207
SH
DFND
1,2
489207
0
0
SAVARA INC
COM
805111101
4035835
739164
SH
DFND
1,2
739164
0
0
SCHOLAR ROCK HLDG CORP
COM
80706P103
4634067
94265
SH
DFND
1,2
94265
0
0
SHATTUCK LABS INC
COM
82024L103
1805454
280786
SH
DFND
1,2
280786
0
0
SKYE BIOSCIENCE INC
COM NEW
83086J200
417269
678928
SH
DFND
1,2
678928
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
2697278
52836
SH
DFND
52836
0
0
SOLAREDGE TECHNOLOGIES INC
NOTE 2.250% 7/0
83417MAE4
6909620
4000000
SH
DFND
4000000
0
0
SOLENO THERAPEUTICS INC
COM
834203309
7241088
216281
SH
DFND
1,2
216281
0
0
SPDR SERIES TRUST
STATE STREET SPD
78464A870
25546001
200000
SH
Put
DFND
1,2
200000
0
0
STRUCTURE THERAPEUTICS INC
SPONSORED ADS
86366E106
2448560
50800
SH
DFND
1,2
50800
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
16925792
724563
SH
DFND
1,2
724563
0
0
TANGO THERAPEUTICS INC
COM
87583X109
7187338
343563
SH
DFND
1,2
343563
0
0
TENAX THERAPEUTICS INC
COM NEW
88032L605
2174880
136015
SH
DFND
1,2
136015
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
31534887
1046975
SH
DFND
1046975
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
2710800
90000
SH
DFND
1,2
90000
0
0
TOWER SEMICONDUCTOR LTD
SHS NEW
M87915274
25573578
145735
SH
DFND
145735
0
0
TREVI THERAPEUTICS INC
COM
89532M101
6848166
574029
SH
DFND
1,2
574029
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
16955526
809333
SH
DFND
1,2
809333
0
0
UPSTREAM BIO INC
COM
91678A107
3222000
358000
SH
DFND
1,2
358000
0
0
VERASTEM INC
COM NEW
92337C203
1821493
343678
SH
DFND
1,2
343678
0
0
VOR BIOPHARMA INC
COM NEW
929033207
5742999
321917
SH
DFND
1,2
321917
0
0
VOYAGER THERAPEUTICS INC
COM
92915B106
1813277
469761
SH
DFND
1,2
469761
0
0
WAVE LIFE SCIENCES LTD
SHS
Y95308105
3974972
548272
SH
DFND
1,2
548272
0
0
WEREWOLF THERAPEUTICS INC
COM
95075A107
521882
626810
SH
DFND
1,2
626810
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
7385050
127000
SH
DFND
1,2
127000
0
0
ZENAS BIOPHARMA INC
COM
98937L105
4190230
214334
SH
DFND
1,2
214334
0
0
ZIM INTEGRATED SHIPPING SERV
SHS
M9T951109
2791783
105950
SH
DFND
105950
0
0