The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   5,166,449 162,161 SH   DFND 1,2 162,161 0 0
89BIO INC COM 282559103   6,004,866 515,882 SH   DFND 1,2 515,882 0 0
ABBVIE INC COM 00287Y109   6,919,800 38,000 SH   DFND 1,2 38,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   2,311,250 125,000 SH   DFND 1,2 125,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   1,849,000 100,000 SH Call DFND 1,2 0 0 0
ADVANCED MICRO DEVICES INC COM 007903107   1,985,390 11,000 SH   DFND   11,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   4,052,841 160,445 SH   DFND 1,2 160,445 0 0
ALECTOR INC COM 014442107   3,371,200 560,000 SH   DFND 1,2 560,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   2,989,000 20,000 SH Call DFND 1,2 0 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   1,777,497 44,841 SH   DFND 1,2 44,841 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109   468,175 30,500 SH   DFND 1,2 30,500 0 0
AMAZON COM INC COM 023135106   9,818,444 54,432 SH   DFND   54,432 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   758,990 267,250 SH   DFND 1,2 267,250 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   681,600 240,000 SH Call DFND 1,2 0 0 0
ANNEXON INC COM 03589W102   81,738 11,400 SH Put DFND 1,2 11,400 0 0
APPLE INC COM 037833100   3,000,900 17,500 SH   DFND   17,500 0 0
APPLIED MATLS INC COM 038222105   6,599,360 32,000 SH   DFND   32,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101   4,209,397 619,029 SH   DFND 1,2 619,029 0 0
APREA THERAPEUTICS INC COM NEW 03836J201   1,806,300 270,000 SH   DFND 1,2 270,000 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100   90,215 43,165 SH   DFND   43,165 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   12,876,565 190,060 SH   DFND 1,2 190,060 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   1,588,251 112,842 SH   DFND 1,2 112,842 0 0
BIOGEN INC COM 09062X103   15,233,397 70,646 SH   DFND 1,2 70,646 0 0
BRIDGEBIO PHARMA INC COM 10806X102   18,117,760 585,956 SH   DFND 1,2 585,956 0 0
BRIDGEBIO PHARMA INC COM 10806X102   1,546,000 50,000 SH Call DFND 1,2 0 0 0
BROADCOM INC COM 11135F101   1,326,735 1,001 SH   DFND   1,001 0 0
CAMTEK LTD ORD M20791105   6,275,127 74,909 SH   DFND   74,909 0 0
CARGO THERAPEUTICS INC COM 14179K101   1,674,000 75,000 SH   DFND 1,2 75,000 0 0
CARTESIAN THERAPEUTICS INC COM 816212104   488,889 25,071 SH   DFND 1,2 25,071 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101   4,590,720 288,000 SH   DFND 1,2 288,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   11,625,522 276,996 SH   DFND 1,2 276,996 0 0
COMPUGEN LTD ORD M25722105   1,984,637 769,239 SH   DFND 1,2 769,239 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   1,373,400 35,000 SH   DFND 1,2 35,000 0 0
CYBIN INC COM 23256X100   10,577,907 25,581,395 SH   DFND 1,2 25,581,395 0 0
CYTOKINETICS INC COM NEW 23282W605   19,747,954 281,671 SH   DFND 1,2 281,671 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   8,138,198 492,627 SH   DFND 1,2 492,627 0 0
DISC MEDICINE INC COM 254604101   3,043,642 48,886 SH   DFND 1,2 48,886 0 0
DISC MEDICINE INC COM 254604101   1,556,500 25,000 SH Call DFND 1,2 0 0 0
ELASTIC N V ORD SHS N14506104   2,004,800 20,000 SH   DFND   20,000 0 0
ELEVATION ONCOLOGY INC COM 28623U101   2,205,900 430,000 SH   DFND 1,2 430,000 0 0
ELI LILLY & CO COM 532457108   11,039,252 14,190 SH   DFND 1,2 14,190 0 0
ENLIGHT RENEWABLE ENERGY LTD SHS M4056D110   2,864,218 169,280 SH   DFND   169,280 0 0
ENPHASE ENERGY INC COM 29355A107   5,708,199 47,183 SH   DFND   47,183 0 0
FIVE9 INC COM 338307101   1,708,025 27,500 SH   DFND   27,500 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   9,573,554 449,041 SH   DFND 1,2 449,041 0 0
GERON CORP COM 374163103   1,268,375 384,356 SH   DFND 1,2 384,356 0 0
GLOBAL E ONLINE LTD SHS M5216V106   7,589,298 208,784 SH   DFND   208,784 0 0
GOSSAMER BIO INC COM 38341P102   1,212,018 1,027,134 SH   DFND 1,2 1,027,134 0 0
GSK PLC SPONSORED ADR 37733W204   4,287,000 100,000 SH   DFND 1,2 100,000 0 0
ICL GROUP LTD SHS M53213100   701,956 130,475 SH   DFND   130,475 0 0
IMMATICS N.V SHS N44445109   7,000,827 666,111 SH   DFND 1,2 666,111 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117   270,000 100,000 SH   DFND 1,2 100,000 0 0
INCYTE CORP COM 45337C102   5,102,005 89,556 SH   DFND 1,2 89,556 0 0
INOZYME PHARMA INC COM 45790W108   10,516,468 1,372,907 SH   DFND 1,2 1,372,907 0 0
INSMED INC COM PAR $.01 457669307   762,353 28,100 SH Call DFND 1,2 0 0 0
JASPER THERAPEUTICS INC COM NEW 471871202   14,833,905 505,242 SH   DFND 1,2 505,242 0 0
JFROG LTD ORD SHS M6191J100   9,922,128 224,381 SH   DFND   224,381 0 0
JOHNSON & JOHNSON COM 478160104   12,628,466 79,831 SH   DFND 1,2 79,831 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   1,849,791 2,051,676 SH   DFND 1,2 2,051,676 0 0
KURA ONCOLOGY INC COM 50127T109   13,028,919 610,826 SH   DFND 1,2 610,826 0 0
LAVA THERAPEUTICS NV SHS N51517105   1,224,048 367,582 SH   DFND 1,2 367,582 0 0
MERCK & CO INC COM 58933Y105   13,670,020 103,600 SH   DFND 1,2 103,600 0 0
MERUS N V COM N5749R100   6,724,465 149,333 SH   DFND 1,2 149,333 0 0
META PLATFORMS INC CL A 30303M102   12,352,670 25,439 SH   DFND   25,439 0 0
MICROSOFT CORP COM 594918104   11,589,995 27,548 SH   DFND   27,548 0 0
MINERALYS THERAPEUTICS INC COM 603170101   8,505,147 658,803 SH   DFND 1,2 658,803 0 0
NICE LTD SPONSORED ADR 653656108   22,382,306 85,881 SH   DFND   85,881 0 0
NOVA LTD COM M7516K103   6,227,102 35,106 SH   DFND   35,106 0 0
NOVARTIS AG SPONSORED ADR 66987V109   4,836,500 50,000 SH   DFND 1,2 50,000 0 0
NOVO-NORDISK A S ADR 670100205   10,667,472 83,080 SH   DFND 1,2 83,080 0 0
NUTRIEN LTD COM 67077M108   1,940,496 35,730 SH   DFND   35,730 0 0
OUTLOOK THERAPEUTICS INC COM 69012T305   6,822,857 571,429 SH   DFND 1,2 571,429 0 0
PERSPECTIVE THERAPEUTICS INC COM 46489V104   14,807,909 12,443,621 SH   DFND 1,2 12,443,621 0 0
PFIZER INC COM 717081103   2,497,500 90,000 SH   DFND 1,2 90,000 0 0
PHARVARIS N V COM N69605108   9,079,387 392,877 SH   DFND 1,2 392,877 0 0
PLIANT THERAPEUTICS INC COM 729139105   3,852,455 258,554 SH   DFND 1,2 258,554 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   10,809,022 177,139 SH   DFND 1,2 177,139 0 0
PRIME MEDICINE INC COM 74168J101   1,436,694 205,242 SH   DFND 1,2 205,242 0 0
PROMIS NEUROSCIENCES INC COM NEW 74346M406   3,503,030 1,834,047 SH   DFND 1,2 1,834,047 0 0
QUALCOMM INC COM 747525103   2,539,500 15,000 SH   DFND   15,000 0 0
REZOLUTE INC COM NEW 76200L309   2,541,611 996,710 SH   DFND 1,2 996,710 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   4,949,471 183,722 SH   DFND 1,2 183,722 0 0
SANOFI SPONSORED ADR 80105N105   24,276,429 499,515 SH   DFND 1,2 499,515 0 0
SAREPTA THERAPEUTICS INC COM 803607100   7,199,788 55,614 SH   DFND 1,2 55,614 0 0
SENTINELONE INC CL A 81730H109   12,839,568 550,818 SH   DFND   550,818 0 0
SHL TELEMEDICINE LTD SPONSORED ADS 78423T200   3,857,982 632,456 SH   DFND   632,456 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   2,851,622 40,175 SH   DFND   40,175 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   1,902,264 26,800 SH Call DFND   0 0 0
SPDR SER TR S&P BIOTECH 78464A870   36,058,200 380,000 SH Put DFND 1,2 380,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   3,458,640 70,269 SH   DFND 1,2 70,269 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   19,348,543 812,964 SH   DFND 1,2 812,964 0 0
TABOOLA.COM LTD ORD SHS M8744T106   5,288,351 1,191,070 SH   DFND   1,191,070 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   5,996,750 425,000 SH   DFND 1,2 425,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   20,666,917 1,464,700 SH   DFND   1,464,700 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   44,202,396 3,132,700 SH Call DFND   0 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   6,007,620 179,600 SH   DFND   179,600 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   11,137,619 238,544 SH   DFND 1,2 238,544 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   2,567,950 55,000 SH Call DFND 1,2 0 0 0
UPWORK INC COM 91688F104   1,434,420 117,000 SH   DFND   117,000 0 0
VARONIS SYS INC COM 922280102   943,400 20,000 SH   DFND   20,000 0 0
VENTYX BIOSCIENCES INC COM 92332V107   5,460,120 992,749 SH   DFND 1,2 992,749 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   5,900,712 1,730,414 SH   DFND 1,2 1,730,414 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   4,269,144 808,550 SH   DFND 1,2 808,550 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   4,061,729 626,810 SH   DFND 1,2 626,810 0 0
WIX COM LTD SHS M98068105   7,269,530 52,877 SH   DFND   52,877 0 0