0001496201-24-000006.txt : 20240515
0001496201-24-000006.hdr.sgml : 20240515
20240515154214
ACCESSION NUMBER: 0001496201-24-000006
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20240331
FILED AS OF DATE: 20240515
DATE AS OF CHANGE: 20240515
EFFECTIVENESS DATE: 20240515
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
ORGANIZATION NAME:
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 24949859
BUSINESS ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
13F-HR
1
primary_doc.xml
X0202
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
03-31-2024
03-31-2024
SPHERA FUNDS MANAGEMENT LTD.
4 ITZHAK SADE BUILDING A
29TH FLOOR
TEL AVIV
L3
6777520
13F HOLDINGS REPORT
028-15863
000312614
802-120694
Y
Investment discretion with regard to a portion of the securities reported herein exercised by Sphera Portfolio Management Ltd, which is wholly owned by Sphera Funds Management Ltd. Per guidance received from the Division of Investment Management, since Sphera Portfolio Management Ltd does not meet the Section 13(f) securities threshold, its holdings are aggregated with those reported for Sphera Funds Management Ltd. Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, Sphera Portfolio Management, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, Sphera Portfolio Management, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S..
Neomi Elpeleg
Chief Financial Officer
972 3 6845564
Neomi Elpeleg
Tel Aviv
L3
05-15-2024
2
105
711744424
false
1
0001599854
028-15865
000172608
802-127045
Sphera Global Healthcare Management LP
2
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
INFORMATION TABLE
2
sphera13fq1.xml
4D MOLECULAR THERAPEUTICS IN
COM
35104E100
5166449
162161
SH
DFND
1,2
162161
0
0
89BIO INC
COM
282559103
6004866
515882
SH
DFND
1,2
515882
0
0
ABBVIE INC
COM
00287Y109
6919800
38000
SH
DFND
1,2
38000
0
0
ACADIA PHARMACEUTICALS INC
COM
004225108
2311250
125000
SH
DFND
1,2
125000
0
0
ACADIA PHARMACEUTICALS INC
COM
004225108
1849000
100000
SH
Call
DFND
1,2
0
0
0
ADVANCED MICRO DEVICES INC
COM
007903107
1985390
11000
SH
DFND
11000
0
0
AKERO THERAPEUTICS INC
COM
00973Y108
4052841
160445
SH
DFND
1,2
160445
0
0
ALECTOR INC
COM
014442107
3371200
560000
SH
DFND
1,2
560000
0
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
2989000
20000
SH
Call
DFND
1,2
0
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
1777497
44841
SH
DFND
1,2
44841
0
0
ALTO NEUROSCIENCE INC
COM SHS
02157Q109
468175
30500
SH
DFND
1,2
30500
0
0
AMAZON COM INC
COM
023135106
9818444
54432
SH
DFND
54432
0
0
AMYLYX PHARMACEUTICALS INC
COM
03237H101
758990
267250
SH
DFND
1,2
267250
0
0
AMYLYX PHARMACEUTICALS INC
COM
03237H101
681600
240000
SH
Call
DFND
1,2
0
0
0
ANNEXON INC
COM
03589W102
81738
11400
SH
Put
DFND
1,2
11400
0
0
APPLE INC
COM
037833100
3000900
17500
SH
DFND
17500
0
0
APPLIED MATLS INC
COM
038222105
6599360
32000
SH
DFND
32000
0
0
APPLIED THERAPEUTICS INC
COM
03828A101
4209397
619029
SH
DFND
1,2
619029
0
0
APREA THERAPEUTICS INC
COM NEW
03836J201
1806300
270000
SH
DFND
1,2
270000
0
0
ARBE ROBOTICS LTD
ORDINARY SHARES
M1R95N100
90215
43165
SH
DFND
43165
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
12876565
190060
SH
DFND
1,2
190060
0
0
ASTRIA THERAPEUTICS INC
COM
04635X102
1588251
112842
SH
DFND
1,2
112842
0
0
BIOGEN INC
COM
09062X103
15233397
70646
SH
DFND
1,2
70646
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
18117760
585956
SH
DFND
1,2
585956
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
1546000
50000
SH
Call
DFND
1,2
0
0
0
BROADCOM INC
COM
11135F101
1326735
1001
SH
DFND
1001
0
0
CAMTEK LTD
ORD
M20791105
6275127
74909
SH
DFND
74909
0
0
CARGO THERAPEUTICS INC
COM
14179K101
1674000
75000
SH
DFND
1,2
75000
0
0
CARTESIAN THERAPEUTICS INC
COM
816212104
488889
25071
SH
DFND
1,2
25071
0
0
CATALYST PHARMACEUTICALS INC
COM
14888U101
4590720
288000
SH
DFND
1,2
288000
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
11625522
276996
SH
DFND
1,2
276996
0
0
COMPUGEN LTD
ORD
M25722105
1984637
769239
SH
DFND
1,2
769239
0
0
CORBUS PHARMACEUTICALS HLDGS
COM NEW
21833P301
1373400
35000
SH
DFND
1,2
35000
0
0
CYBIN INC
COM
23256X100
10577907
25581395
SH
DFND
1,2
25581395
0
0
CYTOKINETICS INC
COM NEW
23282W605
19747954
281671
SH
DFND
1,2
281671
0
0
DAY ONE BIOPHARMACEUTICALS I
COM
23954D109
8138198
492627
SH
DFND
1,2
492627
0
0
DISC MEDICINE INC
COM
254604101
3043642
48886
SH
DFND
1,2
48886
0
0
DISC MEDICINE INC
COM
254604101
1556500
25000
SH
Call
DFND
1,2
0
0
0
ELASTIC N V
ORD SHS
N14506104
2004800
20000
SH
DFND
20000
0
0
ELEVATION ONCOLOGY INC
COM
28623U101
2205900
430000
SH
DFND
1,2
430000
0
0
ELI LILLY & CO
COM
532457108
11039252
14190
SH
DFND
1,2
14190
0
0
ENLIGHT RENEWABLE ENERGY LTD
SHS
M4056D110
2864218
169280
SH
DFND
169280
0
0
ENPHASE ENERGY INC
COM
29355A107
5708199
47183
SH
DFND
47183
0
0
FIVE9 INC
COM
338307101
1708025
27500
SH
DFND
27500
0
0
FUSION PHARMACEUTICALS INC
COM
36118A100
9573554
449041
SH
DFND
1,2
449041
0
0
GERON CORP
COM
374163103
1268375
384356
SH
DFND
1,2
384356
0
0
GLOBAL E ONLINE LTD
SHS
M5216V106
7589298
208784
SH
DFND
208784
0
0
GOSSAMER BIO INC
COM
38341P102
1212018
1027134
SH
DFND
1,2
1027134
0
0
GSK PLC
SPONSORED ADR
37733W204
4287000
100000
SH
DFND
1,2
100000
0
0
ICL GROUP LTD
SHS
M53213100
701956
130475
SH
DFND
130475
0
0
IMMATICS N.V
SHS
N44445109
7000827
666111
SH
DFND
1,2
666111
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
270000
100000
SH
DFND
1,2
100000
0
0
INCYTE CORP
COM
45337C102
5102005
89556
SH
DFND
1,2
89556
0
0
INOZYME PHARMA INC
COM
45790W108
10516468
1372907
SH
DFND
1,2
1372907
0
0
INSMED INC
COM PAR $.01
457669307
762353
28100
SH
Call
DFND
1,2
0
0
0
JASPER THERAPEUTICS INC
COM NEW
471871202
14833905
505242
SH
DFND
1,2
505242
0
0
JFROG LTD
ORD SHS
M6191J100
9922128
224381
SH
DFND
224381
0
0
JOHNSON & JOHNSON
COM
478160104
12628466
79831
SH
DFND
1,2
79831
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
1849791
2051676
SH
DFND
1,2
2051676
0
0
KURA ONCOLOGY INC
COM
50127T109
13028919
610826
SH
DFND
1,2
610826
0
0
LAVA THERAPEUTICS NV
SHS
N51517105
1224048
367582
SH
DFND
1,2
367582
0
0
MERCK & CO INC
COM
58933Y105
13670020
103600
SH
DFND
1,2
103600
0
0
MERUS N V
COM
N5749R100
6724465
149333
SH
DFND
1,2
149333
0
0
META PLATFORMS INC
CL A
30303M102
12352670
25439
SH
DFND
25439
0
0
MICROSOFT CORP
COM
594918104
11589995
27548
SH
DFND
27548
0
0
MINERALYS THERAPEUTICS INC
COM
603170101
8505147
658803
SH
DFND
1,2
658803
0
0
NICE LTD
SPONSORED ADR
653656108
22382306
85881
SH
DFND
85881
0
0
NOVA LTD
COM
M7516K103
6227102
35106
SH
DFND
35106
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
4836500
50000
SH
DFND
1,2
50000
0
0
NOVO-NORDISK A S
ADR
670100205
10667472
83080
SH
DFND
1,2
83080
0
0
NUTRIEN LTD
COM
67077M108
1940496
35730
SH
DFND
35730
0
0
OUTLOOK THERAPEUTICS INC
COM
69012T305
6822857
571429
SH
DFND
1,2
571429
0
0
PERSPECTIVE THERAPEUTICS INC
COM
46489V104
14807909
12443621
SH
DFND
1,2
12443621
0
0
PFIZER INC
COM
717081103
2497500
90000
SH
DFND
1,2
90000
0
0
PHARVARIS N V
COM
N69605108
9079387
392877
SH
DFND
1,2
392877
0
0
PLIANT THERAPEUTICS INC
COM
729139105
3852455
258554
SH
DFND
1,2
258554
0
0
PRAXIS PRECISION MEDICINES I
COM NEW
74006W207
10809022
177139
SH
DFND
1,2
177139
0
0
PRIME MEDICINE INC
COM
74168J101
1436694
205242
SH
DFND
1,2
205242
0
0
PROMIS NEUROSCIENCES INC
COM NEW
74346M406
3503030
1834047
SH
DFND
1,2
1834047
0
0
QUALCOMM INC
COM
747525103
2539500
15000
SH
DFND
15000
0
0
REZOLUTE INC
COM NEW
76200L309
2541611
996710
SH
DFND
1,2
996710
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4949471
183722
SH
DFND
1,2
183722
0
0
SANOFI
SPONSORED ADR
80105N105
24276429
499515
SH
DFND
1,2
499515
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
7199788
55614
SH
DFND
1,2
55614
0
0
SENTINELONE INC
CL A
81730H109
12839568
550818
SH
DFND
550818
0
0
SHL TELEMEDICINE LTD
SPONSORED ADS
78423T200
3857982
632456
SH
DFND
632456
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
2851622
40175
SH
DFND
40175
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
1902264
26800
SH
Call
DFND
0
0
0
SPDR SER TR
S&P BIOTECH
78464A870
36058200
380000
SH
Put
DFND
1,2
380000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
3458640
70269
SH
DFND
1,2
70269
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
19348543
812964
SH
DFND
1,2
812964
0
0
TABOOLA.COM LTD
ORD SHS
M8744T106
5288351
1191070
SH
DFND
1191070
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
5996750
425000
SH
DFND
1,2
425000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
20666917
1464700
SH
DFND
1464700
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
44202396
3132700
SH
Call
DFND
0
0
0
TOWER SEMICONDUCTOR LTD
SHS NEW
M87915274
6007620
179600
SH
DFND
179600
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
11137619
238544
SH
DFND
1,2
238544
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
2567950
55000
SH
Call
DFND
1,2
0
0
0
UPWORK INC
COM
91688F104
1434420
117000
SH
DFND
117000
0
0
VARONIS SYS INC
COM
922280102
943400
20000
SH
DFND
20000
0
0
VENTYX BIOSCIENCES INC
COM
92332V107
5460120
992749
SH
DFND
1,2
992749
0
0
VIGIL NEUROSCIENCE INC
COM
92673K108
5900712
1730414
SH
DFND
1,2
1730414
0
0
VISTAGEN THERAPEUTICS INC
COM
92840H400
4269144
808550
SH
DFND
1,2
808550
0
0
WEREWOLF THERAPEUTICS INC
COM
95075A107
4061729
626810
SH
DFND
1,2
626810
0
0
WIX COM LTD
SHS
M98068105
7269530
52877
SH
DFND
52877
0
0