The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,449 450,000 SH   DFND 1,2,3 450,000 0 0
ABBVIE INC COM 00287Y109 33,448 218,385 SH   DFND 1,2,3 218,385 0 0
ADVANCED MICRO DEVICES INC COM 007903107 1,206 15,773 SH   DFND   15,773 0 0
AIRBNB INC COM CL A 009066101 2,468 27,700 SH   DFND   27,700 0 0
ALNYLAM PHARMACEUTICALS INC CALL 02043Q107 10,939 75,000 SH Call DFND 1,2,3 0 0 75,000
ALTIMMUNE INC COM NEW 02155H200 16,297 1,392,884 SH   DFND 1,2,3 1,392,884 0 0
AMICUS THERAPEUTICS INC COM 03152W109 8,088 753,037 SH   DFND 1,2,3 753,037 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100 237 43,165 SH   DFND   43,165 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 52,764 798,610 SH   DFND 1,2,3 798,610 0 0
C4 THERAPEUTICS INC COM STK 12529R107 5,321 705,736 SH   DFND 1,2,3 705,736 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 11,259 643,731 SH   DFND 1,2,3 643,731 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 2,860 679,400 SH   DFND 1,2,3 679,400 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 10,944 586,820 SH   DFND 1,2,3 586,820 0 0
FIVE9 INC COM 338307101 12,848 140,968 SH   DFND   140,968 0 0
FIVERR INTL LTD NOTE 11/0 33835LAA3 3,786 4,951,000 SH   DFND   4,951,000 0 0
GENERAC HLDGS INC COM 368736104 486 2,310 SH   DFND   2,310 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 204 100,000 SH   DFND 1,2,3 100,000 0 0
IMMATICS N.V SHS N44445109 6,365 730,712 SH   DFND 1,2,3 730,712 0 0
INOZYME PHARMA INC COM 45790W108 5,560 1,165,600 SH   DFND 1,2,3 1,165,600 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 2,294 8,186 SH   DFND   8,186 0 0
INVESCO QQQ TR CALL 46090E103 278,262 992,800 SH Call DFND   0 0 992,800
IVERIC BIO INC COM 46583P102 9,259 962,470 SH   DFND 1,2,3 962,470 0 0
IVERIC BIO INC CALL 46583P102 1,924 200,000 SH Call DFND 1,2,3 0 0 200,000
JOHNSON & JOHNSON COM 478160104 49,073 276,451 SH   DFND 1,2,3 276,451 0 0
KEROS THERAPEUTICS INC COM 492327101 1,879 67,997 SH   DFND 1,2,3 67,997 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 2,478 299,654 SH   DFND 1,2,3 299,654 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,156 91,673 SH   DFND 1,2,3 91,673 0 0
KURA ONCOLOGY INC COM 50127T109 9,066 494,595 SH   DFND 1,2,3 494,595 0 0
LILLY ELI & CO COM 532457108 42,879 132,250 SH   DFND 1,2,3 132,250 0 0
MAGIC SOFTWARE ENTERPRISES L ORD 559166103 1,445 81,293 SH   DFND   81,293 0 0
MERCK & CO INC COM 58933Y105 25,983 285,000 SH   DFND 1,2,3 285,000 0 0
MERUS N V COM N5749R100 9,263 409,161 SH   DFND 1,2,3 409,161 0 0
META PLATFORMS INC CL A 30303M102 8,063 50,000 SH   DFND   50,000 0 0
NICE LTD SPONSORED ADR 653656108 10,678 55,482 SH   DFND   55,482 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 588 250,000 SH   DFND   250,000 0 0
NOVO-NORDISK A S ADR 670100205 29,132 261,440 SH   DFND 1,2,3 261,440 0 0
NVIDIA CORPORATION COM 67066G104 1,711 11,288 SH   DFND   11,288 0 0
ONCORUS INC COM 68236R103 681 540,258 SH   DFND 1,2,3 540,258 0 0
OTONOMO TECHNOLOGIES LTD ORDINARY SHARES M7571L103 431 391,863 SH   DFND   391,863 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 2,676 187,800 SH   DFND 1,2,3 187,800 0 0
RELMADA THERAPEUTICS INC COM 75955J402 8,865 466,830 SH   DFND 1,2,3 466,830 0 0
REZOLUTE INC COM NEW 76200L309 3,734 1,155,897 SH   DFND 1,2,3 1,155,897 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,853 2,525,000 SH   DFND 1,2,3 2,525,000 0 0
SANOFI SPONSORED ADR 80105N105 42,336 846,215 SH   DFND 1,2,3 846,215 0 0
SPDR S&P 500 ETF TR CALL 78462F103 75,261 199,500 SH Call DFND   0 0 199,500
SPDR SER TR S&P BIOTECH 78464A870 32,512 437,748 SH   DFND 1,2,3 437,748 0 0
SPDR SER TR CALL 78464A870 14,854 200,000 SH Call DFND 1,2,3 0 0 200,000
SPRINGWORKS THERAPEUTICS INC COM 85205L107 13,213 536,664 SH   DFND 1,2,3 536,664 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 21,921 1,139,329 SH   DFND 1,2,3 1,139,329 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 8,632 1,147,878 SH   DFND   1,147,878 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624209 25,430 3,381,600 SH Call DFND   0 0 3,381,600
VINCERX PHARMA INC COM NEW 92731L106 93 70,467 SH   DFND 1,2,3 70,467 0 0
VISA INC COM CL A 92826C839 2,481 12,600 SH   DFND   12,600 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 2,896 3,291,135 SH   DFND 1,2,3 3,291,135 0 0
VISTAGEN THERAPEUTICS INC CALL 92840H202 1,320 1,500,000 SH Call DFND 1,2,3 0 0 1,500,000
WEREWOLF THERAPEUTICS INC COM 95075A107 2,442 597,003 SH   DFND 1,2,3 597,003 0 0
WIX COM LTD NOTE 8/1 92940WAD1 566 700,000 SH   DFND   700,000 0 0