0001496201-22-000004.txt : 20220516
0001496201-22-000004.hdr.sgml : 20220516
20220516153422
ACCESSION NUMBER: 0001496201-22-000004
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20220331
FILED AS OF DATE: 20220516
DATE AS OF CHANGE: 20220516
EFFECTIVENESS DATE: 20220516
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 22928178
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
03-31-2022
03-31-2022
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Healthcare US Inc (the "Management Company"). The Management Company is wholly owned by Sphera Global Healthcare Management L.P. ("SGHM") which is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and the Management Company. This Form 13F shall not be construed as an admission by SFML, SGHM, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, SGHM, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972 3 6845535
Israel Mor
Tel Aviv
L3
05-16-2022
3
66
707568
false
1
0001599854
028-15865
Sphera Global Healthcare Management LP
2
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
3
0001891596
028-21415
Sphera Healthcare US Inc.
INFORMATION TABLE
2
sphera13f.xml
ABBVIE INC
COM
00287Y109
30962
190994
SH
DFND
1,2,3
190994
0
0
ADVANCED MICRO DEVICES INC
COM
007903107
10934
100000
SH
DFND
100000
0
0
AIRBNB INC
COM CL A
009066101
5153
30000
SH
DFND
30000
0
0
AIRBNB INC
CALL
009066901
4174
24300
SH
Call
DFND
0
0
24300
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
4044
24768
SH
DFND
1,2,3
24768
0
0
ALTIMMUNE INC
COM NEW
02155H200
7959
1306953
SH
DFND
1,2,3
1306953
0
0
ARBE ROBOTICS LTD
ORDINARY SHARES
M1R95N100
300
43165
SH
DFND
43165
0
0
ASCENDIS PHARMA A/S
SPONSORED ADR
04351P101
3113
26529
SH
DFND
1,2,3
26529
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
55514
836817
SH
DFND
1,2,3
836817
0
0
AYALA PHARMACEUTICALS INC
COM
05465V108
995
250000
SH
DFND
1,2,3
250000
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
16293
211326
SH
DFND
1,2,3
211326
0
0
C4 THERAPEUTICS INC
COM STK
12529R107
8795
362528
SH
DFND
1,2,3
362528
0
0
CAESARSTONE LTD
ORD SHS
M20598104
4503
428046
SH
DFND
428046
0
0
CATERPILLAR INC
COM
149123101
2674
12000
SH
DFND
12000
0
0
CHINOOK THERAPEUTICS INC
COM
16961L106
8077
493677
SH
DFND
1,2,3
493677
0
0
CRINETICS PHARMACEUTICALS IN
COM
22663K107
11457
521947
SH
DFND
1,2,3
521947
0
0
CYCLACEL PHARMACEUTICALS INC
COM
23254L603
1550
508322
SH
DFND
1,2,3
508322
0
0
FATE THERAPEUTICS INC
COM
31189P102
3467
89425
SH
DFND
1,2,3
89425
0
0
FIVE9 INC
COM
338307101
3279
29699
SH
DFND
29699
0
0
FIVE9 INC
CALL
338307101
27479
248900
SH
Call
DFND
0
0
248900
FIVERR INTL LTD
NOTE 11/0
33835LAA3
4227
4951000
SH
DFND
4951000
0
0
GENERAC HLDGS INC
COM
368736104
12548
42211
SH
DFND
42211
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
175
100000
SH
DFND
1,2,3
100000
0
0
IMMATICS N.V
SHS
N44445109
4969
621925
SH
DFND
1,2,3
621925
0
0
IMMUNIC INC
COM
4525EP101
6590
583206
SH
DFND
1,2,3
583206
0
0
INVESCO QQQ TR
PUT
46090E103
45680
126000
SH
Put
DFND
126000
0
0
IRONSOURCE LTD
CL A ORD SHS
M5R75Y101
2976
620000
SH
DFND
620000
0
0
IVERIC BIO INC
COM
46583P102
13029
774130
SH
DFND
1,2,3
774130
0
0
JOHNSON & JOHNSON
COM
478160104
52287
295023
SH
DFND
1,2,3
295023
0
0
KEROS THERAPEUTICS INC
COM
492327101
7590
139581
SH
DFND
1,2,3
139581
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
3118
187599
SH
DFND
1,2,3
187599
0
0
KRYSTAL BIOTECH INC
COM
501147102
1684
25310
SH
DFND
1,2,3
25310
0
0
KURA ONCOLOGY INC
COM
50127T109
9941
618244
SH
DFND
1,2,3
618244
0
0
KYMERA THERAPEUTICS INC
COM
501575104
15576
368061
SH
DFND
1,2,3
368061
0
0
LIANBIO
SPONSORED ADS
53000N108
1020
275007
SH
DFND
1,2,3
275007
0
0
LILLY ELI & CO
COM
532457108
20130
70295
SH
DFND
1,2,3
70295
0
0
MAGIC SOFTWARE ENTERPRISES L
ORD
559166103
1401
81293
SH
DFND
81293
0
0
MASTERCARD INCORPORATED
CL A
57636Q104
4324
12100
SH
DFND
12100
0
0
MERCK & CO INC
COM
58933Y105
22826
278200
SH
DFND
1,2,3
278200
0
0
MERUS N V
COM
N5749R100
10818
409141
SH
DFND
1,2,3
409141
0
0
NAUTILUS BIOTECHNOLOGY INC
COM
63909J108
3646
840000
SH
DFND
1,2,3
840000
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
662
250000
SH
DFND
250000
0
0
NOVO-NORDISK A S
ADR
670100205
26363
237400
SH
DFND
1,2,3
237400
0
0
ONCORUS INC
COM
68236R103
962
540258
SH
DFND
1,2,3
540258
0
0
OTONOMO TECHNOLOGIES LTD
ORDINARY SHARES
M7571L103
772
391863
SH
DFND
391863
0
0
OUTBRAIN INC
COM
69002R103
564
52531
SH
DFND
52531
0
0
PERION NETWORK LTD
SHS NEW
M78673114
6883
306051
SH
DFND
306051
0
0
PFIZER INC
COM
717081103
26665
515070
SH
DFND
1,2,3
515070
0
0
RELMADA THERAPEUTICS INC
COM
75955J402
7861
291252
SH
DFND
1,2,3
291252
0
0
REPLIMUNE GROUP INC
COM
76029N106
3611
212640
SH
DFND
1,2,3
212640
0
0
SANOFI
SPONSORED ADR
80105N105
49924
972415
SH
DFND
1,2,3
972415
0
0
SENTINELONE INC
CL A
81730H109
2518
65000
SH
DFND
65000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
25964
460025
SH
DFND
1,2,3
460025
0
0
SPRINGWORKS THERAPEUTICS INC
CALL
85205L107
7055
125000
SH
Call
DFND
1,2,3
0
0
125000
SUNRUN INC
COM
86771W105
4556
150000
SH
DFND
150000
0
0
SUNRUN INC
CALL
86771W105
6924
228000
SH
Call
DFND
0
0
228000
SYNDAX PHARMACEUTICALS INC
COM
87164F105
22201
1277413
SH
DFND
1,2,3
1277413
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
7821
832878
SH
DFND
832878
0
0
TEVA PHARMACEUTICAL INDS LTD
CALL
881624209
17747
1890000
SH
Call
DFND
0
0
1890000
TEVA PHARMACEUTICAL INDS LTD
PUT
881624209
1972
210000
SH
Put
DFND
210000
0
0
VERONA PHARMA PLC
SPONSORED ADS
925050106
3325
666339
SH
DFND
1,2,3
666339
0
0
VINCERX PHARMA INC
COM NEW
92731L106
2881
720161
SH
DFND
1,2,3
720161
0
0
VISA INC
COM CL A
92826C839
5589
25200
SH
DFND
25200
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
6140
4951423
SH
DFND
1,2,3
4951423
0
0
WEREWOLF THERAPEUTICS INC
COM
95075A107
2570
584203
SH
DFND
1,2,3
584203
0
0
ZIM INTEGRATED SHIPPING SERV
SHS
M9T951109
10761
148000
SH
DFND
148000
0
0