The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 62,852 464,194 SH   DFND 1,2,3 464,194 0 0
ADICET BIO INC COM 007002108 2,624 150,000 SH   DFND 1,2,3 150,000 0 0
AIRBNB INC COM CL A 009066101 7,940 47,689 SH   DFND   47,689 0 0
ALLOT LTD SHS M0854Q105 4,050 340,912 SH   DFND   340,912 0 0
ALTIMMUNE INC COM NEW 02155H200 11,397 1,244,241 SH   DFND 1,2,3 1,244,241 0 0
AMAZON COM INC COM 023135106 14,004 4,200 SH   DFND   4,200 0 0
ANNEXON INC COM 03589W102 1,421 123,637 SH   DFND 1,2,3 123,637 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100 1,120 120,400 SH   DFND   120,400 0 0
ARGENX SE SPONSORED ADR 04016X101 1,503 4,291 SH   DFND 1,2,3 4,291 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 9,930 1,000,000 SH   DFND 1,2,3 1,000,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 1,940 200,000 SH   DFND 1,2,3 200,000 0 0
ASANA INC CL A 04342Y104 7,194 96,500 SH   DFND   96,500 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 61,481 1,055,467 SH   DFND 1,2,3 1,055,467 0 0
AYALA PHARMACEUTICALS INC COM 05465V108 2,128 250,000 SH   DFND 1,2,3 250,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 2,132 216,250 SH   DFND 1,2,3 216,250 0 0
BIOATLA INC COM 09077B104 3,534 180,006 SH   DFND 1,2,3 180,006 0 0
BIOGEN INC COM 09062X103 3,119 13,000 SH   DFND 1,2,3 13,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 19,170 216,977 SH   DFND 1,2,3 216,977 0 0
BURLINGTON STORES INC COM 122017106 12,098 41,501 SH   DFND   41,501 0 0
C4 THERAPEUTICS INC COM STK 12529R107 12,831 398,469 SH   DFND 1,2,3 398,469 0 0
CAESARSTONE LTD ORD SHS M20598104 7,305 644,146 SH   DFND   644,146 0 0
CAMTEK LTD ORD M20791105 3,453 75,000 SH   DFND   75,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 6,444 166,766 SH   DFND 1,2,3 166,766 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 1,821 111,653 SH   DFND 1,2,3 111,653 0 0
COMPASS THERAPEUTICS INC COM 20454B104 2,219 700,000 SH   DFND 1,2,3 700,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 12,024 423,248 SH   DFND 1,2,3 423,248 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 1,977 508,322 SH   DFND 1,2,3 508,322 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 1,124 98,860 SH   DFND 1,2,3 98,860 0 0
DYNE THERAPEUTICS INC COM 26818M108 1,251 105,204 SH   DFND 1,2,3 105,204 0 0
ESSA PHARMA INC COM NEW 29668H708 5,999 422,461 SH   DFND 1,2,3 422,461 0 0
FATE THERAPEUTICS INC COM 31189P102 10,852 185,476 SH   DFND 1,2,3 185,476 0 0
FIVE9 INC COM 338307101 11,749 85,556 SH   DFND   85,556 0 0
FIVE9 INC CALL 338307101 24,512 178,500 SH Call DFND   0 0 178,500
FIVERR INTL LTD NOTE 11/0 33835LAA3 12,175 13,000,000 SH   DFND   13,000,000 0 0
GENERAC HLDGS INC COM 368736104 14,801 42,057 SH   DFND   42,057 0 0
GRAPHITE BIO INC COM 38870X104 8,244 663,194 SH   DFND 1,2,3 663,194 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 5,572 235,695 SH   DFND 1,2,3 235,695 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 439 100,000 SH   DFND 1,2,3 100,000 0 0
IMMATICS N.V SHS N44445109 8,359 621,925 SH   DFND 1,2,3 621,925 0 0
IMMUNIC INC COM 4525EP101 6,379 666,602 SH   DFND 1,2,3 666,602 0 0
INHIBRX INC COM 45720L107 2,705 61,931 SH   DFND 1,2,3 61,931 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 5,379 281,769 SH   DFND 1,2,3 281,769 0 0
IVERIC BIO INC COM 46583P102 8,109 485,001 SH   DFND 1,2,3 485,001 0 0
JOHNSON & JOHNSON COM 478160104 26,537 155,123 SH   DFND 1,2,3 155,123 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 4,183 316,200 SH   DFND 1,2,3 316,200 0 0
KEROS THERAPEUTICS INC COM 492327101 7,003 119,681 SH   DFND 1,2,3 119,681 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 5,640 337,293 SH   DFND 1,2,3 337,293 0 0
KURA ONCOLOGY INC COM 50127T109 11,651 832,238 SH   DFND 1,2,3 832,238 0 0
KYMERA THERAPEUTICS INC COM 501575104 20,232 318,667 SH   DFND 1,2,3 318,667 0 0
LAVA THERAPEUTICS NV SHS N51517105 758 137,857 SH   DFND 1,2,3 137,857 0 0
LESLIES INC COM 527064109 8,815 372,569 SH   DFND   372,569 0 0
LIANBIO SPONSORED ADS 53000N108 1,662 275,007 SH   DFND 1,2,3 275,007 0 0
LILLY ELI & CO COM 532457108 44,111 159,695 SH   DFND 1,2,3 159,695 0 0
MAGIC SOFTWARE ENTERPRISES L ORD 559166103 1,208 57,704 SH   DFND   57,704 0 0
MERCK & CO INC COM 58933Y105 26,550 346,423 SH   DFND 1,2,3 346,423 0 0
MERUS N V COM N5749R100 10,842 340,951 SH   DFND 1,2,3 340,951 0 0
META PLATFORMS INC CL A 30303M102 14,000 41,622 SH   DFND   41,622 0 0
MICROSOFT CORP COM 594918104 16,996 50,536 SH   DFND   50,536 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 4,144 800,000 SH   DFND 1,2,3 800,000 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 921 250,000 SH   DFND   250,000 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 3,999 352,948 SH   DFND 1,2,3 352,948 0 0
ONCORUS INC COM 68236R103 3,010 571,204 SH   DFND 1,2,3 571,204 0 0
OTONOMO TECHNOLOGIES LTD ORDINARY SHARES M7571L103 2,428 593,650 SH   DFND   593,650 0 0
OUTBRAIN INC COM 69002R103 6,037 431,194 SH   DFND   431,194 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 15 129,500 SH   DFND 1,2,3 129,500 0 0
PALO ALTO NETWORKS INC COM 697435105 13,362 24,000 SH   DFND   24,000 0 0
PERION NETWORK LTD SHS NEW M78673114 5,411 225,000 SH   DFND   225,000 0 0
PFIZER INC COM 717081103 13,495 228,528 SH   DFND 1,2,3 228,528 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 4,401 190,525 SH   DFND 1,2,3 190,525 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 3,319 592,592 SH   DFND 1,2,3 592,592 0 0
PROTAGONIST THERAPEUTICS INC CALL 74366E102 8,550 250,000 SH Call DFND 1,2,3 0 0 250,000
RELMADA THERAPEUTICS INC COM 75955J402 10,774 478,208 SH   DFND 1,2,3 478,208 0 0
SANOFI SPONSORED ADR 80105N105 54,278 1,083,400 SH   DFND 1,2,3 1,083,400 0 0
SENTINELONE INC CL A 81730H109 10,089 199,824 SH   DFND   199,824 0 0
SPDR SER TR CALL 78464A870 24,631 220,000 SH Call DFND 1,2,3 0 0 220,000
SPRINGWORKS THERAPEUTICS INC COM 85205L107 21,232 342,566 SH   DFND 1,2,3 342,566 0 0
SUNRUN INC CALL 86771W105 7,820 228,000 SH Call DFND   0 0 228,000
SUTRO BIOPHARMA INC COM 869367102 4,192 281,702 SH   DFND 1,2,3 281,702 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 25,755 1,176,585 SH   DFND 1,2,3 1,176,585 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 6,671 832,877 SH   DFND   832,877 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 3,279 68,734 SH   DFND 1,2,3 68,734 0 0
UNIQURE NV CALL N90064101 2,074 100,000 SH Call DFND 1,2,3 0 0 100,000
VERINT SYS INC COM 92343X100 10,502 200,000 SH   DFND   200,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 5,384 801,256 SH   DFND 1,2,3 801,256 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 969 4,411 SH   DFND 1,2,3 4,411 0 0
VINCERX PHARMA INC COM NEW 92731L106 7,338 720,161 SH   DFND 1,2,3 720,161 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 7,849 4,024,938 SH   DFND 1,2,3 4,024,938 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 7,722 648,391 SH   DFND 1,2,3 648,391 0 0
WIX COM LTD NOTE 8/1 92940WAD1 17,337 18,959,000 SH   DFND   18,959,000 0 0
ZAI LAB LTD ADR 98887Q104 7,017 111,641 SH   DFND 1,2,3 111,641 0 0