0001496201-21-000004.txt : 20210817 0001496201-21-000004.hdr.sgml : 20210817 20210816181558 ACCESSION NUMBER: 0001496201-21-000004 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20210630 FILED AS OF DATE: 20210817 DATE AS OF CHANGE: 20210816 EFFECTIVENESS DATE: 20210817 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 211180285 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 06-30-2021 06-30-2021 SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 N Israel Mor 972-3-6845535 Israel Mor Tel Aviv L3 08-16-2021 2 134 1432197 false 1 028-15864 Sphera Global Healthcare GP Ltd 2 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 13fv3.xml ABBVIE INC COM 00287Y109 41248 366194 SH DFND 1,2 366194 0 0 ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 2861 292194 SH DFND 1,2 292194 0 0 AFFIMED N V COM N01045108 10852 1276702 SH DFND 1,2 1276702 0 0 AGIOS PHARMACEUTICALS INC CALL 00847X104 6393 116000 SH Call DFND 1,2 0 0 116000 ALDEYRA THERAPEUTICS INC COM 01438T106 1700 150000 SH DFND 1,2 150000 0 0 ALLOT LTD SHS M0854Q105 5477 276187 SH DFND 276187 0 0 ALTIMMUNE INC COM NEW 02155H200 6731 683395 SH DFND 1,2 683395 0 0 ALX ONCOLOGY HLDGS INC COM 00166B105 10538 192728 SH DFND 1,2 192728 0 0 AMAZON COM INC COM 023135106 13970 4061 SH DFND 4061 0 0 ANNEXON INC COM 03589W102 3339 148318 SH DFND 1,2 148318 0 0 APOLLO STRATEGIC GROWTH CAPT SHS CL A G0411R106 714 73055 SH DFND 73055 0 0 ARGENX SE 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