0001178913-20-003104.txt : 20201112
0001178913-20-003104.hdr.sgml : 20201112
20201112065945
ACCESSION NUMBER: 0001178913-20-003104
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20200930
FILED AS OF DATE: 20201112
DATE AS OF CHANGE: 20201112
EFFECTIVENESS DATE: 20201112
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 201303257
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
09-30-2020
09-30-2020
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
11-08-2020
2
97
1017694
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
89BIO INC
COM
282559103
1512
58939
SH
DFND
1,2
58939
0
0
ABBVIE INC
COM
00287Y109
69196
790000
SH
DFND
1,2
790000
0
0
ABBVIE INC
CALL
00287Y109
10949
125000
SH
Call
DFND
1,2
0
0
125000
ADMA BIOLOGICS INC
COM
000899104
2584
1081292
SH
DFND
1,2
1081292
0
0
ALBIREO PHARMA INC
COM
01345P106
5793
173600
SH
DFND
1,2
173600
0
0
ALLOT LTD
SHS
M0854Q105
9513
1045337
SH
DFND
1045337
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
1743
198260
SH
DFND
1,2
198260
0
0
ALTIMMUNE INC
COM NEW
02155H200
3208
243000
SH
DFND
1,2
243000
0
0
ALX ONCOLOGY HLDGS INC
COM
00166B105
6871
182070
SH
DFND
1,2
182070
0
0
AMAZON COM INC
COM
023135106
12028
3820
SH
DFND
3820
0
0
AMGEN INC
COM
031162100
27958
110000
SH
DFND
1,2
110000
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
17559
1243550
SH
DFND
1,2
1243550
0
0
ARENA PHARMACEUTICALS INC
COM NEW
040047607
5609
75000
SH
DFND
1,2
75000
0
0
ARGENX SE
SPONSORED ADR
04016X101
2695
10265
SH
DFND
1,2
10265
0
0
ARVINAS INC
COM
04335A105
3187
135000
SH
DFND
1,2
135000
0
0
ARYA SCIENCES ACQUISITION CO
COM CL A
G3166W106
4288
400000
SH
DFND
1,2
400000
0
0
ARYA SCIENCES ACQUISTION CO
UNIT 06/09/2027
G31655114
5489
499000
SH
DFND
1,2
499000
0
0
ASCENDIS PHARMA A/S
SPONSORED ADR
04351P101
5031
32599
SH
DFND
1,2
32599
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
44936
820000
SH
DFND
1,2
820000
0
0
ATHIRA PHARMA INC
COM
04746L104
2068
112000
SH
DFND
1,2
112000
0
0
AVROBIO INC
COM
05455M100
4238
325500
SH
DFND
1,2
325500
0
0
AXOVANT SCIENCES LTD
COM
G0750W203
5327
1152998
SH
DFND
1,2
1152998
0
0
BIOXCEL THERAPEUTICS INC
COM
09075P105
11677
269300
SH
DFND
1,2
269300
0
0
BURLINGTON STORES INC
COM
122017106
7213
35000
SH
DFND
35000
0
0
CARDIFF ONCOLOGY INC
COM
14147L108
568
40000
SH
DFND
1,2
40000
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
5487
370000
SH
DFND
1,2
370000
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
109
87500
SH
DFND
1,2
87500
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
3044
310000
SH
DFND
1,2
310000
0
0
CORBUS PHARMACEUTICALS HLDGS
CALL
21833P103
141
78500
SH
Call
DFND
1,2
0
0
78500
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
17645
343965
SH
DFND
1,2
343965
0
0
DICERNA PHARMACEUTICALS INC
COM
253031108
3598
199980
SH
DFND
1,2
199980
0
0
DOMINOS PIZZA INC
COM
25754A201
6898
16221
SH
DFND
16221
0
0
DYNE THERAPEUTICS INC
COM
26818M108
1413
70000
SH
DFND
1,2
70000
0
0
ESSA PHARMA INC
COM NEW
29668H708
1725
250000
SH
DFND
1,2
250000
0
0
EXICURE INC
COM
30205M101
1291
737557
SH
DFND
1,2
737557
0
0
FACEBOOK INC
CL A
30303M102
9167
35000
SH
DFND
35000
0
0
FATE THERAPEUTICS INC
COM
31189P102
7514
188000
SH
DFND
1,2
188000
0
0
FISERV INC
COM
337738108
7239
70246
SH
DFND
70246
0
0
FIVERR INTL LTD
ORD SHS
M4R82T106
7964
57301
SH
DFND
57301
0
0
GALERA THERAPEUTICS INC
COM
36338D108
4242
469245
SH
DFND
1,2
469245
0
0
GENERAC HLDGS INC
COM
368736104
12974
67000
SH
DFND
67000
0
0
HEALTH SCIENCES ACQ CORP 2
ORD SHS
G4411D109
1100
100000
SH
DFND
1,2
100000
0
0
I MAB
SPONSORED ADS
44975P103
8551
181820
SH
DFND
1,2
181820
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
350
100000
SH
DFND
1,2
100000
0
0
IMMATICS N.V
SHS
N44445109
8488
800000
SH
DFND
1,2
800000
0
0
IMMUNOVANT INC
COM
45258J102
5982
170000
SH
DFND
1,2
170000
0
0
INOZYME PHARMA INC
COM
45790W108
5164
196411
SH
DFND
1,2
196411
0
0
INVESCO QQQ TR
PUT
46090E103
58346
210000
SH
Put
DFND
210000
0
0
IOVANCE BIOTHERAPEUTICS INC
COM
462260100
8329
253000
SH
DFND
1,2
253000
0
0
ISHARES TR
PUT
464287481
12706
73500
SH
Put
DFND
73500
0
0
ITEOS THERAPEUTICS INC
COM
46565G104
6168
250000
SH
DFND
1,2
250000
0
0
JFROG LTD
ORD SHS
M6191J100
8077
95415
SH
DFND
95415
0
0
JOHNSON & JOHNSON
COM
478160104
56574
380000
SH
DFND
1,2
380000
0
0
KALVISTA PHARMACEUTICALS INC
COM
483497103
3023
240140
SH
DFND
1,2
240140
0
0
KINIKSA PHARMACEUTICALS LTD
COM CL A
G5269C101
3983
259990
SH
DFND
1,2
259990
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
9301
143381
SH
DFND
143381
0
0
KRYSTAL BIOTECH INC
COM
501147102
7946
184573
SH
DFND
1,2
184573
0
0
KURA ONCOLOGY INC
COM
50127T109
11015
359494
SH
DFND
1,2
359494
0
0
KYMERA THERAPEUTICS INC
COM
501575104
5170
160000
SH
DFND
1,2
160000
0
0
LARIMAR THERAPEUTICS INC
COM
517125100
5189
342064
SH
DFND
1,2
342064
0
0
LEAP THERAPEUTICS INC
COM
52187K101
1584
800000
SH
DFND
1,2
800000
0
0
LILLY ELI & CO
COM
532457108
23091
156000
SH
DFND
1,2
156000
0
0
LILLY ELI & CO
CALL
532457108
29604
200000
SH
Call
DFND
1,2
0
0
200000
MERCK & CO. INC
COM
58933Y105
73312
883808
SH
DFND
1,2
883808
0
0
MICROSOFT CORP
COM
594918104
10785
51278
SH
DFND
51278
0
0
MIRATI THERAPEUTICS INC
COM
60468T105
5480
33000
SH
DFND
1,2
33000
0
0
MYOKARDIA INC
COM
62857M105
11043
81000
SH
DFND
1,2
81000
0
0
NEUBASE THERAPEUTICS INC
COM
64132K102
1139
150000
SH
DFND
1,2
150000
0
0
NICE LTD
SPONSORED ADR
653656108
14185
62481
SH
DFND
62481
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
681
250000
SH
DFND
250000
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
24784
285000
SH
DFND
1,2
285000
0
0
NURIX THERAPEUTICS INC
COM
67080M103
785
22480
SH
DFND
1,2
22480
0
0
ORGENESIS INC
COM NEW
68619K204
2010
398803
SH
DFND
1,2
398803
0
0
OUTLOOK THERAPEUTICS INC
*W EXP 02/18/202
69012T115
17
129500
SH
DFND
1,2
129500
0
0
PANDION THERAPEUTICS INC
COM
698340106
1089
95000
SH
DFND
1,2
95000
0
0
PASSAGE BIO INC
COM
702712100
3488
266037
SH
DFND
1,2
266037
0
0
PERRIGO CO PLC
SHS
G97822103
3285
71559
SH
DFND
71559
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
5761
59139
SH
DFND
1,2
59139
0
0
REPARE THERAPEUTICS INC
COM
760273102
7539
245000
SH
DFND
1,2
245000
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
5212
228016
SH
DFND
1,2
228016
0
0
SANOFI
SPONSORED ADR
80105N105
56190
1120000
SH
DFND
1,2
1120000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
24084
171500
SH
DFND
1,2
171500
0
0
SAREPTA THERAPEUTICS INC
PUT
803607100
21064
150000
SH
Put
DFND
1,2
150000
0
0
SAREPTA THERAPEUTICS INC
CALL
803607100
21064
150000
SH
Call
DFND
1,2
0
0
150000
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
957
4017
SH
DFND
4017
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
7528
510000
SH
DFND
1,2
510000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
9010
1000000
SH
DFND
1,2
1000000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
5252
582878
SH
DFND
582878
0
0
THERAPEUTICS ACQUISITION COR
COM CL A
88339T103
288
20000
SH
DFND
1,2
20000
0
0
TRILLIUM THERAPEUTICS INC
COM NEW
89620X506
9172
645435
SH
DFND
1,2
645435
0
0
UNIQURE NV
SHS
N90064101
4641
126000
SH
DFND
1,2
126000
0
0
VARONIS SYS INC
COM
922280102
6951
60225
SH
DFND
60225
0
0
VERONA PHARMA PLC
SPONSORED ADS
925050106
6240
1000000
SH
DFND
1,2
1000000
0
0
WAVE LIFE SCIENCES LTD
SHS
Y95308105
7906
931200
SH
DFND
1,2
931200
0
0
Y-MABS THERAPEUTICS INC
COM
984241109
15222
396521
SH
DFND
1,2
396521
0
0
ZENTALIS PHARMACEUTICALS INC
COM
98943L107
6374
194996
SH
DFND
1,2
194996
0
0
ZYMEWORKS INC
COM
98985W102
3726
80000
SH
DFND
1,2
80000
0
0