The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 72,123 734,598 SH   DFND 1,2 734,598 0 0
ADMA BIOLOGICS INC COM 000899104 5,816 1,984,949 SH   DFND 1,2 1,984,949 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 2,105 155,000 SH   DFND 1,2 155,000 0 0
AKOUOS INC COM 00973J101 2,250 100,000 SH   DFND 1,2 100,000 0 0
ALLOT LTD SHS M0854Q105 10,087 963,456 SH   DFND   963,456 0 0
AMAZON COM INC COM 023135106 11,918 4,320 SH   DFND   4,320 0 0
AMGEN INC COM 031162100 18,869 80,000 SH   DFND 1,2 80,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 24,559 1,628,550 SH   DFND 1,2 1,628,550 0 0
APREA THERAPEUTICS INC COM 03836J102 6,138 158,289 SH   DFND 1,2 158,289 0 0
ARGENX SE SPONSORED ADR 04016X101 2,312 10,265 SH   DFND 1,2 10,265 0 0
ARYA SCIENCES ACQUISITION CO UNIT 10/04/2023 G3165V117 4,000 200,000 SH   DFND 1,2 200,000 0 0
ARYA SCIENCES ACQUISTION CO UNIT 06/09/2027 G31655114 3,480 300,000 SH   DFND 1,2 300,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5,084 34,373 SH   DFND 1,2 34,373 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 47,072 890,000 SH   DFND 1,2 890,000 0 0
AXOVANT GENE THERAPIES COM G0750W203 8,060 2,857,998 SH   DFND 1,2 2,857,998 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 1,006 97,805 SH   DFND 1,2 97,805 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 41,160 700,000 SH   DFND 1,2 700,000 0 0
CAMTEK LTD ORD M20791105 468 37,184 SH   DFND   37,184 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 3,375 730,557 SH   DFND 1,2 730,557 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 112 87,500 SH   DFND 1,2 87,500 0 0
COMPUGEN LTD ORD M25722105 3,004 200,000 SH   DFND 1,2 200,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 6,972 700,710 SH   DFND 1,2 700,710 0 0
CORBUS PHARMACEUTICALS HLDGS CALL 21833P103 2,001 238,500 SH Call DFND 1,2 0 0 238,500
DECIPHERA PHARMACEUTICALS IN COM 24344T101 16,899 282,965 SH   DFND 1,2 282,965 0 0
DOMINOS PIZZA INC COM 25754A201 5,365 14,521 SH   DFND   14,521 0 0
DOVER CORP COM 260003108 5,560 57,576 SH   DFND   57,576 0 0
ENPHASE ENERGY INC COM 29355A107 3,330 70,000 SH   DFND   70,000 0 0
EXICURE INC COM 30205M101 4,636 1,900,000 SH   DFND 1,2 1,900,000 0 0
FATE THERAPEUTICS INC COM 31189P102 7,720 225,000 SH   DFND 1,2 225,000 0 0
FISERV INC COM 337738108 9,298 95,246 SH   DFND   95,246 0 0
FIVERR INTL LTD ORD SHS M4R82T106 12,328 167,002 SH   DFND   167,002 0 0
GALERA THERAPEUTICS INC COM 36338D108 3,350 469,245 SH   DFND 1,2 469,245 0 0
HOMOLOGY MEDICINES INC COM 438083107 10,009 658,919 SH   DFND 1,2 658,919 0 0
IMMUNIC INC COM 4525EP101 1,212 100,000 SH   DFND 1,2 100,000 0 0
IMMUNOVANT INC COM 45258J102 2,557 105,000 SH   DFND 1,2 105,000 0 0
INTRA CELLULAR THERAPIES INC CALL 46116X101 5,871 228,700 SH Call DFND 1,2 0 0 228,700
INVESCO QQQ TR PUT 46090E103 38,997 157,500 SH Put DFND   157,500 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 9,553 348,000 SH   DFND 1,2 348,000 0 0
IVERIC BIO INC COM 46583P102 1,020 200,000 SH   DFND 1,2 200,000 0 0
JOHNSON & JOHNSON COM 478160104 42,189 300,000 SH   DFND 1,2 300,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,906 240,140 SH   DFND 1,2 240,140 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 7,440 392,831 SH   DFND 1,2 392,831 0 0
KORNIT DIGITAL LTD SHS M6372Q113 9,422 176,507 SH   DFND   176,507 0 0
KRYSTAL BIOTECH INC COM 501147102 5,988 144,573 SH   DFND 1,2 144,573 0 0
KURA ONCOLOGY INC COM 50127T109 8,712 534,494 SH   DFND 1,2 534,494 0 0
LARIMAR THERAPEUTICS INC COM 517125100 5,099 396,787 SH   DFND 1,2 396,787 0 0
LEAP THERAPEUTICS INC COM 52187K101 1,839 880,000 SH   DFND 1,2 880,000 0 0
LILLY ELI & CO COM 532457108 14,776 90,000 SH   DFND 1,2 90,000 0 0
MEI PHARMA INC COM NEW 55279B202 1,693 410,000 SH   DFND 1,2 410,000 0 0
MERCK & CO. INC COM 58933Y105 60,612 783,808 SH   DFND 1,2 783,808 0 0
MICROSOFT CORP COM 594918104 16,680 81,964 SH   DFND   81,964 0 0
MIRATI THERAPEUTICS INC COM 60468T105 8,220 72,000 SH   DFND 1,2 72,000 0 0
MYOKARDIA INC COM 62857M105 9,662 100,000 SH   DFND 1,2 100,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 651 950,311 SH   DFND 1,2 950,311 0 0
NEUBASE THERAPEUTICS INC COM 64132K102 1,317 150,000 SH   DFND 1,2 150,000 0 0
NICE LTD SPONSORED ADR 653656108 24,489 129,406 SH   DFND   129,406 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 573 250,000 SH   DFND   250,000 0 0
NOVARTIS AG SPONSORED ADR 66987V109 15,721 180,000 SH   DFND 1,2 180,000 0 0
NOVO-NORDISK A S ADR 670100205 26,192 400,000 SH   DFND 1,2 400,000 0 0
ORGENESIS INC COM NEW 68619K204 4,048 665,767 SH   DFND 1,2 665,767 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 33 129,500 SH   DFND 1,2 0 0 129,500
PALO ALTO NETWORKS INC COM 697435105 6,890 30,000 SH   DFND   30,000 0 0
PASSAGE BIO INC COM 702712100 9,414 344,439 SH   DFND 1,2 344,439 0 0
PERRIGO CO PLC SHS G97822103 2,764 50,000 SH   DFND   50,000 0 0
PFIZER INC PUT 717081103 32,700 1,000,000 SH Put DFND 1,2 1,000,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 12,801 82,049 SH   DFND 1,2 82,049 0 0
REPARE THERAPEUTICS INC COM 760273102 7,600 245,000 SH   DFND 1,2 245,000 0 0
RETROPHIN INC COM 761299106 5,103 250,000 SH   DFND 1,2 250,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 7,117 340,016 SH   DFND 1,2 340,016 0 0
SANOFI SPONSORED ADR 80105N105 57,176 1,120,000 SH   DFND 1,2 1,120,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 19,754 123,200 SH   DFND 1,2 123,200 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 6,386 46,017 SH   DFND   46,017 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 2,739 1,233,676 SH   DFND 1,2 1,233,676 0 0
SPDR S&P 500 ETF TR PUT 78462F103 58,280 189,000 SH Put DFND   189,000 0 0
SPDR SER TR PUT 78464A870 83,962 750,000 SH Put DFND 1,2 750,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 3,260 220,000 SH   DFND 1,2 220,000 0 0
SYNDAX PHARMACEUTICALS INC CALL 87164F105 1,482 100,000 SH Call DFND 1,2 0 0 100,000
TCR2 THERAPEUTICS INC COM 87808K106 461 30,000 SH   DFND 1,2 30,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 7,187 582,878 SH   DFND   582,878 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 9,533 1,178,346 SH   DFND 1,2 1,178,346 0 0
UNIQURE NV SHS N90064101 4,957 110,000 SH   DFND 1,2 110,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,478 205,000 SH   DFND 1,2 205,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,050 293,000 SH   DFND 1,2 293,000 0 0
WIX COM LTD SHS M98068105 9,631 37,588 SH   DFND   37,588 0 0
X4 PHARMACEUTICALS INC COM 98420X103 5,273 565,804 SH   DFND 1,2 565,804 0 0
Y-MABS THERAPEUTICS INC COM 984241109 12,193 282,252 SH   DFND 1,2 282,252 0 0
ZYMEWORKS INC COM 98985W102 4,195 116,310 SH   DFND 1,2 116,310 0 0