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    <nameOfIssuer>ABBVIE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00287Y109</cusip>
    <value>72123</value>
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    <nameOfIssuer>ADMA BIOLOGICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>000899104</cusip>
    <value>5816</value>
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    <nameOfIssuer>AKEBIA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00972D105</cusip>
    <value>2105</value>
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      <Sole>155000</Sole>
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      <None>0</None>
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    <nameOfIssuer>AKOUOS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00973J101</cusip>
    <value>2250</value>
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    <nameOfIssuer>ALLOT LTD</nameOfIssuer>
    <titleOfClass>SHS</titleOfClass>
    <cusip>M0854Q105</cusip>
    <value>10087</value>
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      <Sole>963456</Sole>
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    <nameOfIssuer>AMAZON COM INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>023135106</cusip>
    <value>11918</value>
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    <nameOfIssuer>AMGEN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>031162100</cusip>
    <value>18869</value>
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      <sshPrnamt>80000</sshPrnamt>
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      <Sole>80000</Sole>
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    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03152W109</cusip>
    <value>24559</value>
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    <nameOfIssuer>APREA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03836J102</cusip>
    <value>6138</value>
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      <Sole>158289</Sole>
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    <nameOfIssuer>ARGENX SE</nameOfIssuer>
    <titleOfClass>SPONSORED ADR</titleOfClass>
    <cusip>04016X101</cusip>
    <value>2312</value>
    <shrsOrPrnAmt>
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      <Sole>10265</Sole>
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  <infoTable>
    <nameOfIssuer>ARYA SCIENCES ACQUISITION CO</nameOfIssuer>
    <titleOfClass>UNIT 10/04/2023</titleOfClass>
    <cusip>G3165V117</cusip>
    <value>4000</value>
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    <nameOfIssuer>ARYA SCIENCES ACQUISTION CO</nameOfIssuer>
    <titleOfClass>UNIT 06/09/2027</titleOfClass>
    <cusip>G31655114</cusip>
    <value>3480</value>
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    <nameOfIssuer>ASCENDIS PHARMA A S</nameOfIssuer>
    <titleOfClass>SPONSORED ADR</titleOfClass>
    <cusip>04351P101</cusip>
    <value>5084</value>
    <shrsOrPrnAmt>
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    <nameOfIssuer>ASTRAZENECA PLC</nameOfIssuer>
    <titleOfClass>SPONSORED ADR</titleOfClass>
    <cusip>046353108</cusip>
    <value>47072</value>
    <shrsOrPrnAmt>
      <sshPrnamt>890000</sshPrnamt>
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    <nameOfIssuer>AXOVANT GENE THERAPIES</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>G0750W203</cusip>
    <value>8060</value>
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    <nameOfIssuer>BELLUS HEALTH INC NEW</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>07987C204</cusip>
    <value>1006</value>
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    <nameOfIssuer>BRISTOL-MYERS SQUIBB CO</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>110122108</cusip>
    <value>41160</value>
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    <nameOfIssuer>CAMTEK LTD</nameOfIssuer>
    <titleOfClass>ORD</titleOfClass>
    <cusip>M20791105</cusip>
    <value>468</value>
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      <sshPrnamt>37184</sshPrnamt>
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      <Sole>37184</Sole>
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    <nameOfIssuer>CATALYST PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>14888U101</cusip>
    <value>3375</value>
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      <Sole>730557</Sole>
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    <nameOfIssuer>CELLECTAR BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>COM PAR</titleOfClass>
    <cusip>15117F500</cusip>
    <value>112</value>
    <shrsOrPrnAmt>
      <sshPrnamt>87500</sshPrnamt>
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    <otherManager>1,2</otherManager>
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      <Sole>87500</Sole>
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    <nameOfIssuer>COMPUGEN LTD</nameOfIssuer>
    <titleOfClass>ORD</titleOfClass>
    <cusip>M25722105</cusip>
    <value>3004</value>
    <shrsOrPrnAmt>
      <sshPrnamt>200000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
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      <Sole>200000</Sole>
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      <None>0</None>
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    <nameOfIssuer>CONCERT PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>206022105</cusip>
    <value>6972</value>
    <shrsOrPrnAmt>
      <sshPrnamt>700710</sshPrnamt>
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    <investmentDiscretion>DFND</investmentDiscretion>
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      <Sole>700710</Sole>
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      <None>0</None>
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    <nameOfIssuer>CORBUS PHARMACEUTICALS HLDGS</nameOfIssuer>
    <titleOfClass>CALL</titleOfClass>
    <cusip>21833P103</cusip>
    <value>2001</value>
    <shrsOrPrnAmt>
      <sshPrnamt>238500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>DFND</investmentDiscretion>
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  <infoTable>
    <nameOfIssuer>DECIPHERA PHARMACEUTICALS IN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>24344T101</cusip>
    <value>16899</value>
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      <Sole>282965</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>DOMINOS PIZZA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>25754A201</cusip>
    <value>5365</value>
    <shrsOrPrnAmt>
      <sshPrnamt>14521</sshPrnamt>
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      <Sole>14521</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>DOVER CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>260003108</cusip>
    <value>5560</value>
    <shrsOrPrnAmt>
      <sshPrnamt>57576</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>57576</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>ENPHASE ENERGY INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>29355A107</cusip>
    <value>3330</value>
    <shrsOrPrnAmt>
      <sshPrnamt>70000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>70000</Sole>
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      <None>0</None>
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    <nameOfIssuer>EXICURE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>30205M101</cusip>
    <value>4636</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1900000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
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      <Sole>1900000</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>FATE THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>31189P102</cusip>
    <value>7720</value>
    <shrsOrPrnAmt>
      <sshPrnamt>225000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
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      <Sole>225000</Sole>
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      <None>0</None>
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    <nameOfIssuer>FISERV INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>337738108</cusip>
    <value>9298</value>
    <shrsOrPrnAmt>
      <sshPrnamt>95246</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>95246</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>FIVERR INTL LTD</nameOfIssuer>
    <titleOfClass>ORD SHS</titleOfClass>
    <cusip>M4R82T106</cusip>
    <value>12328</value>
    <shrsOrPrnAmt>
      <sshPrnamt>167002</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>167002</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>GALERA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>36338D108</cusip>
    <value>3350</value>
    <shrsOrPrnAmt>
      <sshPrnamt>469245</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
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      <Sole>469245</Sole>
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      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>HOMOLOGY MEDICINES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>438083107</cusip>
    <value>10009</value>
    <shrsOrPrnAmt>
      <sshPrnamt>658919</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
    <votingAuthority>
      <Sole>658919</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IMMUNIC INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>4525EP101</cusip>
    <value>1212</value>
    <shrsOrPrnAmt>
      <sshPrnamt>100000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
    <votingAuthority>
      <Sole>100000</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>IMMUNOVANT INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45258J102</cusip>
    <value>2557</value>
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      <Sole>105000</Sole>
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      <None>0</None>
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    <nameOfIssuer>INTRA CELLULAR THERAPIES INC</nameOfIssuer>
    <titleOfClass>CALL</titleOfClass>
    <cusip>46116X101</cusip>
    <value>5871</value>
    <shrsOrPrnAmt>
      <sshPrnamt>228700</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
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      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>228700</None>
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    <nameOfIssuer>INVESCO QQQ TR</nameOfIssuer>
    <titleOfClass>PUT</titleOfClass>
    <cusip>46090E103</cusip>
    <value>38997</value>
    <shrsOrPrnAmt>
      <sshPrnamt>157500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Put</putCall>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>157500</Sole>
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      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IOVANCE BIOTHERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>462260100</cusip>
    <value>9553</value>
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    <nameOfIssuer>JOHNSON &amp; JOHNSON</nameOfIssuer>
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    <nameOfIssuer>KALVISTA PHARMACEUTICALS INC</nameOfIssuer>
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    <nameOfIssuer>KARYOPHARM THERAPEUTICS INC</nameOfIssuer>
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    <nameOfIssuer>KORNIT DIGITAL LTD</nameOfIssuer>
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    <nameOfIssuer>KRYSTAL BIOTECH INC</nameOfIssuer>
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    <nameOfIssuer>KURA ONCOLOGY INC</nameOfIssuer>
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    <nameOfIssuer>LARIMAR THERAPEUTICS INC</nameOfIssuer>
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    <nameOfIssuer>LEAP THERAPEUTICS INC</nameOfIssuer>
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      <sshPrnamt>880000</sshPrnamt>
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    <nameOfIssuer>LILLY ELI &amp; CO</nameOfIssuer>
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      <sshPrnamt>90000</sshPrnamt>
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    <nameOfIssuer>MEI PHARMA INC</nameOfIssuer>
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    <nameOfIssuer>MERCK &amp; CO. INC</nameOfIssuer>
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    <nameOfIssuer>MICROSOFT CORP</nameOfIssuer>
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    <nameOfIssuer>MIRATI THERAPEUTICS INC</nameOfIssuer>
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    <nameOfIssuer>MYOKARDIA INC</nameOfIssuer>
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    <nameOfIssuer>NEOS THERAPEUTICS INC</nameOfIssuer>
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    <nameOfIssuer>NEUBASE THERAPEUTICS INC</nameOfIssuer>
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    <nameOfIssuer>NICE LTD</nameOfIssuer>
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    <nameOfIssuer>NICE SYS INC</nameOfIssuer>
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    <nameOfIssuer>NOVARTIS AG</nameOfIssuer>
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    <nameOfIssuer>ORGENESIS INC</nameOfIssuer>
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    <nameOfIssuer>OUTLOOK THERAPEUTICS INC</nameOfIssuer>
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    <nameOfIssuer>PASSAGE BIO INC</nameOfIssuer>
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    <nameOfIssuer>SPDR S&amp;P 500 ETF TR</nameOfIssuer>
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