0001178913-20-002378.txt : 20200813
0001178913-20-002378.hdr.sgml : 20200813
20200813060249
ACCESSION NUMBER: 0001178913-20-002378
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20200630
FILED AS OF DATE: 20200813
DATE AS OF CHANGE: 20200813
EFFECTIVENESS DATE: 20200813
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 201097054
BUSINESS ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 21 HA'ARBA'AH STREET
CITY: TEL AVIV
STATE: L3
ZIP: 64739
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
06-30-2020
06-30-2020
false
SPHERA FUNDS MANAGEMENT LTD.
21 HA'ARBA'AH STREET
TEL AVIV
L3
64739
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972-3-6845535
/s/ Israel Mor
Tel Aviv
L3
08-06-2020
2
87
1063322
1
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
2
0001599854
028-15865
Sphera Global Healthcare Management LP
INFORMATION TABLE
2
infotable.xml
ABBVIE INC
COM
00287Y109
72123
734598
SH
DFND
1,2
734598
0
0
ADMA BIOLOGICS INC
COM
000899104
5816
1984949
SH
DFND
1,2
1984949
0
0
AKEBIA THERAPEUTICS INC
COM
00972D105
2105
155000
SH
DFND
1,2
155000
0
0
AKOUOS INC
COM
00973J101
2250
100000
SH
DFND
1,2
100000
0
0
ALLOT LTD
SHS
M0854Q105
10087
963456
SH
DFND
963456
0
0
AMAZON COM INC
COM
023135106
11918
4320
SH
DFND
4320
0
0
AMGEN INC
COM
031162100
18869
80000
SH
DFND
1,2
80000
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
24559
1628550
SH
DFND
1,2
1628550
0
0
APREA THERAPEUTICS INC
COM
03836J102
6138
158289
SH
DFND
1,2
158289
0
0
ARGENX SE
SPONSORED ADR
04016X101
2312
10265
SH
DFND
1,2
10265
0
0
ARYA SCIENCES ACQUISITION CO
UNIT 10/04/2023
G3165V117
4000
200000
SH
DFND
1,2
200000
0
0
ARYA SCIENCES ACQUISTION CO
UNIT 06/09/2027
G31655114
3480
300000
SH
DFND
1,2
300000
0
0
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
5084
34373
SH
DFND
1,2
34373
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
47072
890000
SH
DFND
1,2
890000
0
0
AXOVANT GENE THERAPIES
COM
G0750W203
8060
2857998
SH
DFND
1,2
2857998
0
0
BELLUS HEALTH INC NEW
COM NEW
07987C204
1006
97805
SH
DFND
1,2
97805
0
0
BRISTOL-MYERS SQUIBB CO
COM
110122108
41160
700000
SH
DFND
1,2
700000
0
0
CAMTEK LTD
ORD
M20791105
468
37184
SH
DFND
37184
0
0
CATALYST PHARMACEUTICALS INC
COM
14888U101
3375
730557
SH
DFND
1,2
730557
0
0
CELLECTAR BIOSCIENCES INC
COM PAR
15117F500
112
87500
SH
DFND
1,2
87500
0
0
COMPUGEN LTD
ORD
M25722105
3004
200000
SH
DFND
1,2
200000
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
6972
700710
SH
DFND
1,2
700710
0
0
CORBUS PHARMACEUTICALS HLDGS
CALL
21833P103
2001
238500
SH
Call
DFND
1,2
0
0
238500
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
16899
282965
SH
DFND
1,2
282965
0
0
DOMINOS PIZZA INC
COM
25754A201
5365
14521
SH
DFND
14521
0
0
DOVER CORP
COM
260003108
5560
57576
SH
DFND
57576
0
0
ENPHASE ENERGY INC
COM
29355A107
3330
70000
SH
DFND
70000
0
0
EXICURE INC
COM
30205M101
4636
1900000
SH
DFND
1,2
1900000
0
0
FATE THERAPEUTICS INC
COM
31189P102
7720
225000
SH
DFND
1,2
225000
0
0
FISERV INC
COM
337738108
9298
95246
SH
DFND
95246
0
0
FIVERR INTL LTD
ORD SHS
M4R82T106
12328
167002
SH
DFND
167002
0
0
GALERA THERAPEUTICS INC
COM
36338D108
3350
469245
SH
DFND
1,2
469245
0
0
HOMOLOGY MEDICINES INC
COM
438083107
10009
658919
SH
DFND
1,2
658919
0
0
IMMUNIC INC
COM
4525EP101
1212
100000
SH
DFND
1,2
100000
0
0
IMMUNOVANT INC
COM
45258J102
2557
105000
SH
DFND
1,2
105000
0
0
INTRA CELLULAR THERAPIES INC
CALL
46116X101
5871
228700
SH
Call
DFND
1,2
0
0
228700
INVESCO QQQ TR
PUT
46090E103
38997
157500
SH
Put
DFND
157500
0
0
IOVANCE BIOTHERAPEUTICS INC
COM
462260100
9553
348000
SH
DFND
1,2
348000
0
0
IVERIC BIO INC
COM
46583P102
1020
200000
SH
DFND
1,2
200000
0
0
JOHNSON & JOHNSON
COM
478160104
42189
300000
SH
DFND
1,2
300000
0
0
KALVISTA PHARMACEUTICALS INC
COM
483497103
2906
240140
SH
DFND
1,2
240140
0
0
KARYOPHARM THERAPEUTICS INC
COM
48576U106
7440
392831
SH
DFND
1,2
392831
0
0
KORNIT DIGITAL LTD
SHS
M6372Q113
9422
176507
SH
DFND
176507
0
0
KRYSTAL BIOTECH INC
COM
501147102
5988
144573
SH
DFND
1,2
144573
0
0
KURA ONCOLOGY INC
COM
50127T109
8712
534494
SH
DFND
1,2
534494
0
0
LARIMAR THERAPEUTICS INC
COM
517125100
5099
396787
SH
DFND
1,2
396787
0
0
LEAP THERAPEUTICS INC
COM
52187K101
1839
880000
SH
DFND
1,2
880000
0
0
LILLY ELI & CO
COM
532457108
14776
90000
SH
DFND
1,2
90000
0
0
MEI PHARMA INC
COM NEW
55279B202
1693
410000
SH
DFND
1,2
410000
0
0
MERCK & CO. INC
COM
58933Y105
60612
783808
SH
DFND
1,2
783808
0
0
MICROSOFT CORP
COM
594918104
16680
81964
SH
DFND
81964
0
0
MIRATI THERAPEUTICS INC
COM
60468T105
8220
72000
SH
DFND
1,2
72000
0
0
MYOKARDIA INC
COM
62857M105
9662
100000
SH
DFND
1,2
100000
0
0
NEOS THERAPEUTICS INC
COM
64052L106
651
950311
SH
DFND
1,2
950311
0
0
NEUBASE THERAPEUTICS INC
COM
64132K102
1317
150000
SH
DFND
1,2
150000
0
0
NICE LTD
SPONSORED ADR
653656108
24489
129406
SH
DFND
129406
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
573
250000
SH
DFND
250000
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
15721
180000
SH
DFND
1,2
180000
0
0
NOVO-NORDISK A S
ADR
670100205
26192
400000
SH
DFND
1,2
400000
0
0
ORGENESIS INC
COM NEW
68619K204
4048
665767
SH
DFND
1,2
665767
0
0
OUTLOOK THERAPEUTICS INC
*W EXP 02/18/202
69012T115
33
129500
SH
DFND
1,2
0
0
129500
PALO ALTO NETWORKS INC
COM
697435105
6890
30000
SH
DFND
30000
0
0
PASSAGE BIO INC
COM
702712100
9414
344439
SH
DFND
1,2
344439
0
0
PERRIGO CO PLC
SHS
G97822103
2764
50000
SH
DFND
50000
0
0
PFIZER INC
PUT
717081103
32700
1000000
SH
Put
DFND
1,2
1000000
0
0
REATA PHARMACEUTICALS INC
CL A
75615P103
12801
82049
SH
DFND
1,2
82049
0
0
REPARE THERAPEUTICS INC
COM
760273102
7600
245000
SH
DFND
1,2
245000
0
0
RETROPHIN INC
COM
761299106
5103
250000
SH
DFND
1,2
250000
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
7117
340016
SH
DFND
1,2
340016
0
0
SANOFI
SPONSORED ADR
80105N105
57176
1120000
SH
DFND
1,2
1120000
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
19754
123200
SH
DFND
1,2
123200
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
6386
46017
SH
DFND
46017
0
0
SOLENO THERAPEUTICS INC
COM NEW
834203200
2739
1233676
SH
DFND
1,2
1233676
0
0
SPDR S&P 500 ETF TR
PUT
78462F103
58280
189000
SH
Put
DFND
189000
0
0
SPDR SER TR
PUT
78464A870
83962
750000
SH
Put
DFND
1,2
750000
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
3260
220000
SH
DFND
1,2
220000
0
0
SYNDAX PHARMACEUTICALS INC
CALL
87164F105
1482
100000
SH
Call
DFND
1,2
0
0
100000
TCR2 THERAPEUTICS INC
COM
87808K106
461
30000
SH
DFND
1,2
30000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
7187
582878
SH
DFND
582878
0
0
TRILLIUM THERAPEUTICS INC
COM NEW
89620X506
9533
1178346
SH
DFND
1,2
1178346
0
0
UNIQURE NV
SHS
N90064101
4957
110000
SH
DFND
1,2
110000
0
0
VIKING THERAPEUTICS INC
COM
92686J106
1478
205000
SH
DFND
1,2
205000
0
0
WAVE LIFE SCIENCES LTD
SHS
Y95308105
3050
293000
SH
DFND
1,2
293000
0
0
WIX COM LTD
SHS
M98068105
9631
37588
SH
DFND
37588
0
0
X4 PHARMACEUTICALS INC
COM
98420X103
5273
565804
SH
DFND
1,2
565804
0
0
Y-MABS THERAPEUTICS INC
COM
984241109
12193
282252
SH
DFND
1,2
282252
0
0
ZYMEWORKS INC
COM
98985W102
4195
116310
SH
DFND
1,2
116310
0
0