The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 3,239 90,000 SH   DFND 1,2 90,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 2,958 130,000 SH   DFND 1,2 130,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 5,634 1,069,089 SH   DFND 1,2 1,069,089 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 16,230 165,713 SH   DFND 1,2 165,713 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 2,655 673,881 SH   DFND 1,2 673,881 0 0
ALLOT LTD SHS M0854Q105 5,328 661,031 SH   DFND   661,031 0 0
AMAZON COM INC COM 023135106 3,819 2,200 SH   DFND   2,200 0 0
AMICUS THERAPEUTICS INC COM 03152W109 23,501 2,930,320 SH   DFND 1,2 2,930,320 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 763 500,000 SH   DFND 1,2 500,000 0 0
ARGENX SE SPONSORED ADR 04016X101 4,397 38,581 SH   DFND 1,2 38,581 0 0
ARQULE INC COM 04269E107 14,933 2,082,643 SH   DFND 1,2 2,082,643 0 0
ARVINAS INC COM 04335A105 4,424 205,281 SH   DFND 1,2 205,281 0 0
ARYA SCIENCES ACQUISITION CO UNIT 10/04/2023 G3165V117 2,188 200,000 SH   DFND 1,2 200,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 7,106 73,773 SH   DFND 1,2 73,773 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 1,180 120,000 SH   DFND 1,2 120,000 0 0
AUDIOCODES LTD ORD M15342104 6,207 328,263 SH   DFND   328,263 0 0
AVROBIO INC COM 05455M100 1,784 126,324 SH   DFND 1,2 126,324 0 0
AXOVANT GENE THERAPIES LTD COM G0750W203 4,319 668,541 SH   DFND 1,2 668,541 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 788 750,000 SH   DFND 1,2 750,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 3,122 42,500 SH   DFND 1,2 42,500 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 56,283 1,109,900 SH   DFND 1,2 1,109,900 0 0
BURLINGTON STORES INC COM 122017106 3,896 19,500 SH   DFND   19,500 0 0
CAESARSTONE LTD ORD SHS M20598104 7,666 461,509 SH   DFND   461,509 0 0
CELGENE CORP COM 151020104 24,825 250,000 SH   DFND 1,2 250,000 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 175 87,500 SH   DFND 1,2 87,500 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 2,473 6,000 SH   DFND   6,000 0 0
CHIASMA INC COM 16706W102 4,901 990,000 SH   DFND 1,2 990,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 823 140,000 SH   DFND 1,2 140,000 0 0
CUE BIOPHARMA INC COM 22978P106 422 50,000 SH   DFND 1,2 50,000 0 0
DELEK US HLDGS INC NEW COM 24665A103 1,815 50,000 SH   DFND   50,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 8,113 565,000 SH   DFND 1,2 565,000 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 523 117,837 SH   DFND 1,2 117,837 0 0
EXICURE INC COM 30205M101 6,674 2,637,988 SH   DFND 1,2 2,637,988 0 0
FISERV INC COM 337738108 6,969 67,279 SH   DFND   67,279 0 0
FIVERR INTL LTD ORD SHS M4R82T106 2,643 141,355 SH   DFND   141,355 0 0
FORESCOUT TECHNOLOGIES INC COM 34553D101 6,587 173,696 SH   DFND   173,696 0 0
GILEAD SCIENCES INC COM 375558103 12,993 205,000 SH   DFND 1,2 205,000 0 0
GILEAD SCIENCES INC CALL 375558103 31,690 500,000 SH   DFND 1,2 0 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 8,512 74,000 SH   DFND 1,2 74,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 5,109 374,031 SH   DFND 1,2 374,031 0 0
HEALTH SCIENCES ACQUSTN CORP UNIT 04/01/2024 42227C201 1,073 100,000 SH   DFND 1,2 100,000 0 0
ITURAN LOCATION AND CONTROL SHS M6158M104 3,354 135,311 SH   DFND   135,311 0 0
JOHNSON & JOHNSON COM 478160104 51,752 400,000 SH   DFND 1,2 400,000 0 0
KORNIT DIGITAL LTD SHS M6372Q113 4,050 131,588 SH   DFND   131,588 0 0
KRYSTAL BIOTECH INC COM 501147102 4,085 117,625 SH   DFND 1,2 117,625 0 0
MELLANOX TECHNOLOGIES LTD SHS M51363113 8,425 76,875 SH   DFND   76,875 0 0
MERCK & CO INC COM 58933Y105 39,565 470,000 SH   DFND 1,2 470,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 316 200,000 SH   DFND 1,2 200,000 0 0
MICROSOFT CORP COM 594918104 7,472 53,741 SH   DFND   53,741 0 0
MINERVA NEUROSCIENCES INC COM 603380106 5,906 762,018 SH   DFND 1,2 762,018 0 0
NEOS THERAPEUTICS INC COM 64052L106 5,784 3,908,265 SH   DFND 1,2 3,908,265 0 0
NICE LTD SPONSORED ADR 653656108 8,224 57,193 SH   DFND   57,193 0 0
NOVA MEASURING INSTRUMENTS L COM M7516K103 1,650 51,949 SH   DFND   51,949 0 0
NOVO-NORDISK A S ADR 670100205 23,265 450,000 SH   DFND 1,2 450,000 0 0
PALO ALTO NETWORKS INC COM 697435105 6,721 32,976 SH   DFND   32,976 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 6,973 260,000 SH   DFND 1,2 260,000 0 0
PRECISION BIOSCIENCES INC COM 74019P108 3,062 365,000 SH   DFND 1,2 365,000 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 1,108 90,217 SH   DFND 1,2 90,217 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 5,270 915,000 SH   DFND 1,2 915,000 0 0
PTC THERAPEUTICS INC COM 69366J200 10,484 310,000 SH   DFND 1,2 310,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 5,080 63,269 SH   DFND 1,2 63,269 0 0
RETROPHIN INC COM 761299106 3,827 330,203 SH   DFND 1,2 330,203 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 7,689 660,000 SH   DFND 1,2 660,000 0 0
SANOFI SPONSORED ADR 80105N105 32,431 700,000 SH   DFND 1,2 700,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 18,682 248,038 SH   DFND 1,2 248,038 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 5,358 64,002 SH   DFND   64,002 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 6,721 310,000 SH   DFND 1,2 310,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 7,384 346,380 SH   DFND 1,2 346,380 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 1,542 2,141,800 SH   DFND 1,2 2,141,800 0 0
SUTRO BIOPHARMA INC COM 869367102 3,841 422,589 SH   DFND 1,2 422,589 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624209 10,664 1,550,000 SH   DFND   0 0 0
TUFIN SOFTWARE TECHNOLOGIS L SHS M8893U102 201 12,231 SH   DFND   12,231 0 0
UNIQURE NV SHS N90064101 6,986 177,500 SH   DFND 1,2 177,500 0 0
UROGEN PHARMA LTD COM M96088105 8,003 335,817 SH   DFND 1,2 335,817 0 0
VERINT SYS INC COM 92343X100 5,753 134,489 SH   DFND   134,489 0 0
WABTEC CORP COM 929740108 2,874 40,000 SH   DFND   40,000 0 0
WIX COM LTD SHS M98068105 4,307 36,890 SH   DFND   36,890 0 0
X4 PHARMACEUTICALS INC COM 98420X103 602 47,391 SH   DFND 1,2 47,391 0 0
Y MABS THERAPEUTICS INC COM 984241109 4,951 190,000 SH   DFND 1,2 190,000 0 0
ZYMEWORKS INC COM 98985W102 4,216 170,000 SH   DFND 1,2 170,000 0 0