0001178913-18-002380.txt : 20180813 0001178913-18-002380.hdr.sgml : 20180813 20180813083013 ACCESSION NUMBER: 0001178913-18-002380 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180630 FILED AS OF DATE: 20180813 DATE AS OF CHANGE: 20180813 EFFECTIVENESS DATE: 20180813 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD. CENTRAL INDEX KEY: 0001496201 IRS NUMBER: 000000000 STATE OF INCORPORATION: L3 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-15863 FILM NUMBER: 181010350 BUSINESS ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 BUSINESS PHONE: 972-3-6845535 MAIL ADDRESS: STREET 1: 21 HA'ARBA'AH STREET CITY: TEL AVIV STATE: L3 ZIP: 64739 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001496201 XXXXXXXX 06-30-2018 06-30-2018 false SPHERA FUNDS MANAGEMENT LTD.

21 HA'ARBA'AH STREET TEL AVIV L3 64739

13F HOLDINGS REPORT 028-15863 Y Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 50% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint 50% of the members of the board of directors of the General Partner (the "Board of Directors") and 50% of the members to the investment committee of the Management Company (the "Investment Committee"), and therefore may be deemed to share control of the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S. Ori Goldfarb 972-3-6845535 /s/ Ori Goldfarb Tel Aviv L3 08-05-2018 2 110 725360 true 1 0001599855 028-15864 Sphera Global Healthcare GP Ltd. 2 0001599854 028-15865 Sphera Global Healthcare Management LP INFORMATION TABLE 2 infotable.xml ABEONA THERAPEUTICS INC COM 00289Y107 3571 223172 SH DFND 1,2 223172 0 0 ADAMAS PHARMACEUTICALS INC COM 00548A106 5518 213625 SH DFND 1,2 213625 0 0 ADVANCE AUTO PARTS INC COM 00751Y106 724 5336 SH DFND 5336 0 0 AEGLEA BIOTHERAPEUTICS INC COM 00773J103 5386 509118 SH DFND 1,2 509118 0 0 AERPIO PHARMACEUTICALS INC COM 00810B105 4580 1103554 SH DFND 1,2 1103554 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 6733 846935 SH DFND 1,2 846935 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 19932 160544 SH DFND 1,2 160544 0 0 ALLENA PHARMACEUTICALS INC COM 018119107 3484 267349 SH DFND 1,2 267349 0 0 ALLERGAN PLC SHS G0177J108 10003 60000 SH DFND 1,2 60000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 19228 195232 SH DFND 1,2 195232 0 0 ALPHABET INC CAP STK CL A 02079K305 3691 3269 SH DFND 3269 0 0 AMGEN INC COM 031162100 18459 100000 SH DFND 1,2 100000 0 0 AMICUS THERAPEUTICS INC COM 03152W109 18573 1189056 SH DFND 1,2 1189056 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 2438 110803 SH DFND 1,2 110803 0 0 APTINYX INC COM 03836N103 2477 102474 SH DFND 1,2 102474 0 0 AQUINOX PHARMACEUTICALS INC COM 03842B101 683 257613 SH DFND 1,2 257613 0 0 ARQULE INC COM 04269E107 8282 1497683 SH DFND 1,2 1497683 0 0 ARRAY BIOPHARMA INC COM 04269X105 5702 339804 SH DFND 1,2 339804 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5192 78048 SH DFND 1,2 78048 0 0 AUDIOCODES LTD ORD M15342104 461 59226 SH DFND 59226 0 0 AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 4716 176045 SH DFND 1,2 176045 0 0 BIOGEN INC COM 09062X103 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