X0306 4 2013-11-21 0000920465 LA JOLLA PHARMACEUTICAL CO LJPC 0001495521 Zarrabian Saiid 4370 LA JOLLA VILLAGE DRIVE SUITE 400 SAN DIEGO CA 92122 1 0 0 0 Common Stock 5461588 D Stock Option (Right to Buy) .12 2013-11-21 4 A 0 900000 0 A 2013-11-21 Common Stock 900000 900000 D These options represent a right to purchase a total of 900,000 shares of the Issuer's Common Stock, one quarter of which shall be fully vested and exercisable on November 21, 2014, with the remaining 650,000 shares vesting monthly thereafter over the next three years in 36 equal increments of 18,750 shares. /s/ George F. Tidmarsh by power of attorney for Saiid Zarrabian 2013-11-26