<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-07-21</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000737207</issuerCik>
        <issuerName>Marina Biotech, Inc.</issuerName>
        <issuerTradingSymbol>MRNA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001494875</rptOwnerCik>
            <rptOwnerName>Taylor Michael Douglas</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3830 MONTE VILLA PARKWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOTHELL</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98021</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Marina Biotech Stock Options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.24</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-07-21</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-05-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2005</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Marina Biotech Stock Options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.25</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-07-21</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2020-02-05</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6378</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Marina Biotech Stock Options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.24</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-07-21</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2020-03-18</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2005</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The options, which were granted under the Stock Incentive Plan of Cequent Pharmaceuticals, Inc., were assumed by the issuer on July 21, 2010 in connection with the closing of the merger between the issuer and Cequent Pharmaceuticals.  In connection with the reporting person's stock option agreement, 25% of the options fully vested as of May 1, 2009, and an additional 2.0833% of the original number of shares will vest at the end of each successive one-month period following thereafter.</footnote>
        <footnote id="F2">The options, which were granted under the Stock Incentive Plan of Cequent Pharmaceuticals, Inc., were assumed by the issuer on July 21, 2010 in connection with the closing of the merger between the issuer and Cequent Pharmaceuticals.  In connection with the reporting person's stock option agreement, 25% of the options fully vested as of the date of the acquisition of Cequent by the issuer, and an additional 2.0833% of the original number of shares shall vest at the end of each successive one-month period following thereafter.</footnote>
    </footnotes>

    <remarks>See attached footnote page</remarks>

    <ownerSignature>
        <signatureName>/s/Peter S. Garcia
Attorney in Fact</signatureName>
        <signatureDate>2010-07-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
