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Stock-based Compensation (Tables)
 6 Months Ended
Jun. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Schedule of Allocated Stock-Based Compensation Expense
The Company recorded total stock-based compensation expense related to stock options, restricted stock units and it's employee stock purchase plan awarded under the Company's 2010 Stock Incentive Plan, as amended and restated effective as of October 12, 20217 (the 2010 Plan), 2017 Employee Stock Purchase Plan (2017 Plan) and grants made pursuant to the Nasdaq inducement grant exception in accordance with Nasdaq Listing Rule 5635(c)(4) (the "Nasdaq Inducement Grant Exception") in the following expense categories in the accompanying consolidated statements of operations as follows:
Three Months Ended June 30,Six Months Ended June 30,
2024202320242023
Cost of product sales$33 $12 $50 $18 
Research and development5 126 62 281 
General and administrative2,697 1,365 4,079 2,726 
$2,735 $1,503 $4,191 $3,025 
Schedule of Stock Option Activity
The following table summarizes the activity related to stock option grants to employees and non-employees for the six months ended June 30, 2024:
 SharesWeighted
average
exercise price
per share		Weighted
average
remaining
contractual life
Outstanding at December 31, 20238,527,626 $5.03 6.55
Granted1,685,601 1.56 
Exercised— — 
Expired(846,640)9.73 
Forfeited(68,276)1.90 
Outstanding at June 30, 20249,298,311 $4.00 7.34
Exercisable at June 30, 20244,926,384 $3.97 6.07
Schedule of Fair Value Options using Black-Scholes Pricing Model The Company calculated the fair value of the stock option grants using the following weighted average assumptions:
Six Months Ended June 30,
20242023
Risk free interest rate4.26 %3.97 %
Expected term (in years)5.96.08
Expected volatility75.02 %75.31 %
Annual dividend yield0.00 %0.00 %
The Company calculated the fair value of each grant under the 2017 Employee Stock Purchase Plan using the following weighted average assumptions:
Six Months Ended June 30,
20242023
Risk free interest rate0.05 %0.05 %
Expected term (in years)0.50.5
Expected volatility65.06 %71.43 %
Annual dividend yield— %— %
Schedule of Nonvested Restricted Stock Units Activity
The following table summarizes the activity related to RSUs granted to employees for the six months ended June 30, 2024:
 Shares
Balance at December 31, 20231,897,421 
Granted3,574,200 
Vested and settled(638,204)
Expired/forfeited/canceled(95,542)
Balance at June 30, 20244,737,875 
Expected to vest at June 30, 20244,737,875