Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Total revenues	$ 34,631	$ 7,065
Costs and expenses:
Cost of product sales	5,294	1,588
Research and development	20,783	10,099
Selling, general and administrative	104,155	95,618
Total costs and expenses	130,232	107,305
Loss from operations	(95,601)	(100,240)
Other (income) expense:
Grant and other income	0	(406)
Interest income	(2,359)	(2,453)
Interest expense	9,623	9,229
Foreign currency losses	33	48
Loss on extinguishment of debt	7,155	0
Net loss	$ (110,053)	$ (106,658)
Net loss per share of common stock, basic and diluted (in dollars per share)	$ (2.63)	$ (2.68)
Weighted average common shares outstanding, basic and diluted (in shares)	41,877,527	39,765,983
Net product revenues
Total revenues	$ 30,401	$ 7,065
Licensing revenues
Total revenues	$ 4,230	$ 0