Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Total revenues	$ 12,397	$ 1,902	$ 23,550	$ 4,042
Costs and expenses:
Cost of product sales	1,389	319	3,216	870
Research and development	5,547	2,989	15,404	6,736
Selling, general and administrative	25,270	22,086	77,610	71,957
Total operating expenses	32,206	25,394	96,230	79,563
Loss from operations	(19,809)	(23,492)	(72,680)	(75,521)
Other (income) expense:
Grant and other income	0	(42)	0	(374)
Interest income	(559)	(680)	(1,959)	(1,738)
Interest expense	2,372	2,361	7,148	6,855
Foreign currency (gains) losses	31	(8)	34	13
Loss on extinguishment of debt	7,155	0	7,155	0
Net loss	$ (28,808)	$ (25,123)	$ (85,058)	$ (80,277)
Net loss per share of common stock, basic and diluted (in USD per share)	$ (0.69)	$ (0.61)	$ (2.06)	$ (2.04)
Weighted average common shares outstanding, basic and diluted (in shares)	41,454,181	41,207,167	41,341,570	39,260,903
Net product revenues
Total revenues	$ 8,667	$ 1,902	$ 19,320	$ 4,042
Licensing revenues
Total revenues	$ 3,730	$ 0	$ 4,230	$ 0