Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Total revenues	$ 6,677	$ 1,274	$ 11,153	$ 2,139
Costs and expenses:
Licensing revenues	1,089	351	1,827	551
Research and development	5,295	2,046	9,857	3,747
Selling, general and administrative	26,000	21,860	52,340	49,871
Total operating expenses	32,384	24,257	64,024	54,169
Loss from operations	(25,707)	(22,983)	(52,871)	(52,030)
Other (income) expense:
Grant and other income	0	(145)	0	(333)
Interest income	(716)	(582)	(1,400)	(1,058)
Interest expense	2,389	2,301	4,777	4,494
Foreign currency (gains) losses	(3)	24	3	21
Net loss	$ (27,377)	$ (24,581)	$ (56,251)	$ (55,154)
Net loss per share of common stock, basic and diluted (in USD per share)	$ (0.66)	$ (0.64)	$ (1.36)	$ (1.44)
Weighted average common shares outstanding, basic and diluted (in shares)	41,310,608	38,688,366	41,283,478	38,271,101
Net product revenues
Total revenues	$ 6,677	$ 1,274	$ 10,653	$ 2,139
Licensing revenues
Total revenues	$ 0	$ 0	$ 500	$ 0