SCHEDULE 13G/A 0001172661-25-001202 0001281446 XXXXXXXX LIVE 5 Common Stock, $0.001 par value per share 03/31/2025 0001494650 OPTINOSE, INC. 68404V209 777 Township Line Road Suite 300 Yardley PA 19067 Rule 13d-1(c) Great Point Partners, LLC DE 0.00 526315.00 0.00 526315.00 526315.00 N 4.94 IA OO Dr. Jeffrey R. Jay, M.D. X1 0.00 526315.00 0.00 526315.00 526315.00 N 4.94 HC IN Ms. Lillian Nordahl X1 0.00 526315.00 0.00 526315.00 526315.00 N 4.94 HC IN OPTINOSE, INC. 777 Township Line Road, Suite 300, Yardley, Pennsylvania 19067 Great Point Partners, LLC Dr. Jeffrey R. Jay, M.D. Ms. Lillian Nordahl The Reporting Persons have entered into a Joint Filing Agreement, dated May 15, 2025, a copy of which is filed with this SCHEDULE 13G/A as Exhibit A, pursuant to which the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act. The address of the principal business office of each of the Reporting Persons is 165 Mason Street, 3rd Floor Greenwich, CT 06830 Great Point Partners, LLC is a limited liability company organized under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Ms. Lillian Nordahl is a citizen of the United States. Y 526,315 4.94 0 526,315 0 526,315 1. Great Point Partners, LLC (a) Amount beneficially owned: 526,315 (b) Percent of class: 4.94 (c) Number of shares as to which the person has: (i) Sole power to vote or direct the vote: 0 (ii) Shared power to vote or direct the vote: 526,315 (iii) Sole power to dispose or to direct the disposition of: 0 (iv) Shared power to dispose or to direct the disposition of: 526,315 2. Dr. Jeffrey R. Jay, M.D. (a) Amount beneficially owned: 526,315 (b) Percent of class: 4.94 (c) Number of shares as to which the person has: (i) Sole power to vote or direct the vote: 0 (ii) Shared power to vote or direct the vote: 526,315 (iii) Sole power to dispose or to direct the disposition of: 0 (iv) Shared power to dispose or to direct the disposition of: 526,315 3. Ms. Lillian Nordahl (a) Amount beneficially owned: 526,315 (b) Percent of class: 4.94 (c) Number of shares as to which the person has: (i) Sole power to vote or direct the vote: 0 (ii) Shared power to vote or direct the vote: 526,315 (iii) Sole power to dispose or to direct the disposition of: 0 (iv) Shared power to dispose or to direct the disposition of: 526,315 Based on a total of 10,127,381 shares outstanding, as reported by the Issuer in its Form 10-K/A filed with the Securities and Exchange Commission (the "SEC") on April 30, 2024 and 526,316 shares of the Common Stock issuable upon exercise of warrants held by the reporting persons (subject to the Beneficial Ownership Cap). N Y N See Item 4. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. JOINT FILING STATEMENT PURSUANT TO RULE 13d-1(k) The undersigned hereby agree as follows: (i) Each of them is individually eligible to use the SCHEDULE 13G/A to which this Exhibit is attached, and such SCHEDULE 13G/A is filed on behalf of each of them; and (ii) Each of them is responsible for the timely filing of such SCHEDULE 13G/A and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate. Dated: May 15, 2025 Great Point Partners, LLC By: /s/ Dr. Jeffrey R. Jay, M.D. Dr. Jeffrey R. Jay, M.D., as Senior Managing Member Dr. Jeffrey R. Jay, M.D. By: /s/ Dr. Jeffrey R. Jay, M.D. Dr. Jeffrey R. Jay, M.D. Ms. Lillian Nordahl By: /s/ Ms. Lillian Nordahl Ms. Lillian Nordahl Great Point Partners, LLC /s/ Dr. Jeffrey R. Jay, M.D 05/15/2025 Dr. Jeffrey R. Jay, M.D. /s/ Dr. Jeffrey R. Jay, M.D 05/15/2025 Ms. Lillian Nordahl /s/ Ms. Lillian Nordahl 05/15/2025