X0306 4 2017-10-17 0 0001494650 OptiNose, Inc. OPTN 0001194459 DOYLE WILLIAM F C/O WFD VENTURES LLC 1500 BROADWAY, 17TH FLOOR NEW YORK NY 10036 1 0 1 0 Common Stock 2017-10-17 4 C 0 18803 A 18803 D Common Stock 2017-10-17 4 C 0 3013139 A 3013139 I TKWD Ventures LLC Series B-2 Convertible Preferred Stock 2017-10-17 4 C 0 4563 0 D Common Stock 13177 0 D Series C-1 Convertible Preferred Stock 2017-10-17 4 C 0 1142 0 D Common Stock 3297 0 D Series C-2 Convertible Preferred Stock 2017-10-17 4 C 0 473 0 D Common Stock 1365 0 D Series D Convertible Preferred Stock 2017-10-17 4 C 0 334 0 D Common Stock 964 0 D Series B-2 Convertible Preferred Stock 2017-10-17 4 C 0 719225 0 D Common Stock 2077049 0 I TKWD Ventures LLC Series C Convertible Preferred Stock 2017-10-17 4 C 0 41160 0 D Common Stock 118865 0 I TKWD Ventures LLC Series C-1 Convertible Preferred Stock 2017-10-17 4 C 0 190440 0 D Common Stock 549971 0 I TKWD Ventures LLC Series C-2 Convertible Preferred Stock 2017-10-17 4 C 0 92543 0 D Common Stock 267254 0 I TKWD Ventures LLC Represents the total number of shares of Common Stock received upon conversion of Series B-2, Series C, Series C-1, Series C-2 and Series D Preferred Stock in connection with the closing of the Issuer's initial public offering. The Series B-2, Series C, Series C-1, Series C-2 and Series D Preferred Stock converted into Common Stock on a 2.8879-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B-2, Series C, Series C-1, Series C-2 and Series D Preferred Stock were convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date. Mr. Doyle is a managing director of WFD Ventures LLC, which is the general partner of TKWD Ventures LLC. Mr. Doyle possesses sole voting and investment power over shares owned by TKWD Ventures LLC. /s/ Leanne Kelly, attorney-in-fact 2017-10-19