SCHEDULE 13G 0001000097 XXXXXXXX LIVE Common Stock, $0.001 par value per share 04/09/2025 0001494650 OptiNose, Inc. 68404V209 777 Township Line Road Suite 300 Yardley PA 19067 Rule 13d-1(c) KINGDON CAPITAL MANAGEMENT, L.L.C. b DE 0.00 520485.00 0.00 520485.00 520485.00 N 5.1 IA MARK KINGDON b X1 0.00 520485.00 0.00 520485.00 520485.00 N 5.1 HC IN OptiNose, Inc. 777 Township Line Road, Suite 300, Yardley, Pennsylvania 19067 Kingdon Capital Management, L.L.C. Mark Kingdon Kingdon Capital Management, L.L.C. 152 West 57th Street, 50th Floor New York, New York 10019 United States of America Mark Kingdon c/o Kingdon Capital Management, L.L.C. 152 West 57th Street, 50th Floor New York, New York 10019 United States of America Kingdon Capital Management, L.L.C. - Delaware Mark Kingdon - United States Y Kingdon Capital Management, L.L.C. - 520,485 Mark Kingdon - 520,485 Kingdon Capital Management, L.L.C. - 5.1% Mark Kingdon - 5.1% Kingdon Capital Management, L.L.C. - 0 Mark Kingdon - 0 Kingdon Capital Management, L.L.C. - 520,485 Mark Kingdon - 520,485 Kingdon Capital Management, L.L.C. - 0 Mark Kingdon - 0 Kingdon Capital Management, L.L.C. - 520,485 Mark Kingdon - 520,485 Y N All of the securities reported in this Schedule 13G are directly owned by advisory clients of Kingdon Capital Management, L.L.C. None of those advisory clients may be deemed to beneficially own more than 5% of the Common Stock, $0.001 par value per share. N Please see Exhibit B attached hereto. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit A - Joint Filing Agreement Exhibit B - Control Person Identification KINGDON CAPITAL MANAGEMENT, L.L.C. By: /s/ Richard Weinstein 04/14/2025 MARK KINGDON By: /s/ Mark Kingdon 04/14/2025 * Each Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his, her or its pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. To the extent that "ownership of 5 percent or less of a class" was indicated in Item 5, such response only applies to the Reporting Person(s) that indicated elsewhere herein that it beneficially owns five percent (5%) or less of the class.