X0306 4 2022-11-28 0 0001493566 OTONOMY, INC. OTIC 0001248190 CAPPS VICKIE L C/O OTONOMY, INC. 4796 EXECUTIVE DRIVE SAN DIEGO CA 92121 1 0 0 0 Common Stock 2022-11-28 4 S 0 42242 0.1028 D 3400 D Common Stock 1600 I By Spouse This sale price represents the weighted average sale price of the shares sold ranging from $0.1014 to $0.1031 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. /s/ Paul E. Cayer, Attorney-in-fact 2022-11-29