X0306 4 2022-03-25 0 0001493566 OTONOMY, INC. OTIC 0001857476 Foster Alan Charles C/O OTONOMY, INC. 4796 EXECUTIVE DRIVE SAN DIEGO CA 92121 0 1 0 0 Chief Scientific Officer Common Stock 2022-03-25 4 S 0 1827 2.388 D 179576 D Common Stock 2022-03-28 4 S 0 2559 2.413 D 177017 D Shares were sold to cover tax obligations in connection with the vesting of Restricted Stock Units. This sale price represents the weighted average sale price of the shares sold ranging from $2.34 to $2.41 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Holder will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. This sale price represents the weighted average sale price of the shares sold ranging from $2.36 to $2.44 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Holder will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. /s/ Paul E. Cayer, by power of attorney 2022-03-29