X0306 4 2020-06-23 0 0001493566 OTONOMY, INC. OTIC 0001248190 CAPPS VICKIE L C/O OTONOMY, INC. 4796 EXECUTIVE DRIVE SAN DIEGO CA 92121 1 0 0 0 Stock Option (right to buy) 3.56 2020-06-23 4 A 0 17500 0.00 A 2030-06-22 Common Stock 17500 17500 D 100% of the shares subject to the option shall vest upon the earlier of (i) the one year anniversary of the grant date, and (ii) the date of the Issuer's next annual meeting of stockholders occurring after the grant date, provided that the Reporting Person remains a service provider through such date. /s/ Paul E. Cayer, by power of attorney 2020-06-25