X0306 4 2017-03-06 0 0001493566 OTONOMY, INC. OTIC 0001239648 LOUMEAU ERIC J C/O OTONOMY, INC. 4796 EXECUTIVE DRIVE SAN DIEGO CA 92121 0 1 0 0 GC & Chief Compliance Officer Employee Stock Option (right to buy) 14.00 2017-03-06 4 A 0 50000 0.00 A 2027-03-06 Common Stock 50000 50000 D One-fourth (1/4) of the shares subject to the option vest on March 6, 2018 and one forty-eighth (1/48) of the shares vest monthly thereafter. In addition to the option to purchase 50,000 shares of common stock as set forth on Table II, the Reporting Person currently holds options to purchase up to an aggregate of 170,000 shares of common stock, which options vest according to their terms. /s/ Eric J. Loumeau 2017-03-08