X0306 4 2016-09-06 0 0001493566 Otonomy, Inc. OTIC 0001439275 LeBel Carl C/O OTONOMY, INC. 6275 NANCY RIDGE DRIVE, SUITE 100 SAN DIEGO CA 92121 0 1 0 0 Chief Scientific Officer Common Stock 2015-12-01 4 A 0 263 13.60 A 9183 D Common Stock 2016-06-01 4 A 0 275 13.1325 A 9458 D Common Stock 2016-09-06 4 M 0 12133 6.33 A 21591 D Common Stock 2016-09-06 4 M 0 3813 6.33 A 25404 D Common Stock 2016-09-06 4 M 0 5304 3.17 A 30708 D Common Stock 2016-09-06 4 S 0 12133 17.95 D 18575 D Common Stock 2016-09-06 4 S 0 3813 17.95 D 14762 D Common Stock 2016-09-06 4 S 0 5304 17.95 D 9458 D Employee Stock Option (right to buy) 6.33 2016-09-06 4 M 0 15946 0.00 D 2024-06-30 Common Stock 15946 35434 D Employee Stock Option (right to buy) 3.17 2016-09-06 4 M 0 5304 0.00 D 2020-11-19 Common Stock 5304 19885 D Acquired pursuant to the Issuer's 2014 Employee Stock Purchase Plan. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. One-fourth of the shares subject to the option vested on April 23, 2015 and one forty-eighth of the shares vest monthly thereafter. In addition to the remaining options to purchase 55,319 shares of common stock as set forth in Table II, the Reporting Person also holds options to purchase up to an aggregate of 239,392 shares of common stock, which options vest according to their terms. One-fourth of the shares subject to the option vested on November 19, 2011 and one forty-eighth of the shares vest monthly thereafter. /s/ Eric J. Loumeau, by power of attorney 2016-09-08