Stockholders' Equity - Schedule of Shares of Common Stock Reserved for Future Issuance (Detail) - shares	Jun. 30, 2022	Dec. 31, 2021	Jun. 30, 2021
Class of Stock [Line Items]
Total common stock reserved for future issuance	31,973,061	28,883,700
Options to Purchase Common Stock [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	12,541,406	11,707,568
Pre-funded Warrants [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	11,111,110	11,111,110
Unvested Restricted Stock Unit [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	1,786,869	1,650,250	809,750
Available Future Grant Year [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	2,864,259	1,500,062
2014 Employee Stock Purchase Plan [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	3,669,417	2,914,710