Stockholders' Equity - Schedule of Shares of Common Stock Reserved for Future Issuance (Detail) - shares	Dec. 31, 2021	Dec. 31, 2020
Class of Stock [Line Items]
Total common stock reserved for future issuance	28,883,700	18,698,302
Options to Purchase Common Stock [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	11,707,568	9,842,744
Pre-funded Warrants [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	11,111,110	4,000,000
Unvested Restricted Stock Unit [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	1,650,250	0
Available Future Grant Year [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	1,500,062	2,553,854
2014 Employee Stock Purchase Plan [Member]
Class of Stock [Line Items]
Total common stock reserved for future issuance	2,914,710	2,301,704