X0306 4 2021-12-20 0 0001799850 Renovacor, Inc. RCOR 0001493215 RTW INVESTMENTS, LP 40 10TH AVENUE 7TH FLOOR NEW YORK NY 10014 0 0 1 0 0001493280 WONG RODERICK C/O RTW INVESTMENTS, LP 40 10TH AVENUE, 7TH FLOOR NEW YORK NY 10014 0 0 1 0 0001493219 RTW MASTER FUND, LTD. C/O INTERTRUST CORP. SERV. (CAYMAN) LTD. ONE NEXUS WAY CAMANA BAY, GRAND CAYMAN E9 KY1-9005 CAYMAN ISLANDS 0 0 1 0 Common Stock, par value $0.0001 per share ("Common Stock") 2021-12-20 4 P 0 129516 7.9622 A 2567056 I See footnote Common Stock 2021-12-20 4 P 0 800 7.7331 A 2567856 I See footnote Common Stock 2021-12-21 4 P 0 3609 7.9977 A 2571465 I See footnote Common Stock 2021-12-21 4 P 0 1864 7.9945 A 2573329 I See footnote Common Stock 2021-12-22 4 P 0 3500 7.9514 A 2576829 I See footnote The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP (the "Adviser"), which is deemed the beneficial owner of shares of Common Stock held by RTW Master Fund, Ltd., RTW Innovation Master Fund, Ltd. and RTW Venture Fund Limited (collectively, the "Funds"), which are investment funds managed by the Adviser, and (ii) Roderick Wong, M.D., who serves as the Managing Partner and Chief Investment Officer of the Adviser. Dr. Wong exercises voting and dispositive control over the shares of Common Stock held by the Adviser and is therefore deemed to be a beneficial owner of securities owned or controlled by the Adviser. Each Reporting Person disclaims beneficial ownership in the securities reported on this Form 4 except to the extent of its or his pecuniary interest, if any, therein, and this report shall not be deemed to be an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. RTW Investments, LP, By: /s/ Roderick Wong, Managing Partner 2021-12-22 Roderick Wong, M.D., By: /s/ Roderick Wong 2021-12-22 RTW Master Fund, Ltd., By: /s/ Roderick Wong, By: Roderick Wong, Title: Director 2021-12-22