<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-08-29</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001651944</issuerCik>
        <issuerName>DermTech, Inc.</issuerName>
        <issuerTradingSymbol>DMTK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001493215</rptOwnerCik>
            <rptOwnerName>RTW INVESTMENTS, LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>412 WEST 15TH STREET, FLOOR 9</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10011</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001493280</rptOwnerCik>
            <rptOwnerName>WONG RODERICK</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O RTW INVESTMENTS, LP</rptOwnerStreet1>
            <rptOwnerStreet2>412 WEST 15TH STREET, FLOOR 9</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>92037</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2386871</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By RTW Investments, LP</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Warrant to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>9.54</value>
                <footnoteId id="F9"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2019-08-29</value>
                <footnoteId id="F6"/>
            </exerciseDate>
            <expirationDate>
                <value>2020-09-25</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>31449</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F7"/>
                    <footnoteId id="F8"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By RTW Investments, LP</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrant to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>9.54</value>
                <footnoteId id="F9"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2019-08-29</value>
                <footnoteId id="F10"/>
            </exerciseDate>
            <expirationDate>
                <value>2021-03-07</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>31449</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F7"/>
                    <footnoteId id="F11"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By RTW Investments, LP</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On August 29, 2019, Issuer completed a merger transaction (the &quot;Merger&quot;) pursuant to an Agreement and Plan of Merger, dated May 29, 2019, by and among Issuer, DT Merger Sub, Inc., and DermTech Operations, Inc., formerly known as DermTech, Inc. (&quot;DermTech Operations&quot;), as filed with the Securities and Exchange Commission on Form 8-K on May 29, 2019 (the &quot;Merger Agreement&quot;). Pursuant to the Merger Agreement, all issued and outstanding common stock of DermTech Operations converted into and became common stock of Issuer, and all issued and outstanding warrants of DermTech Operations converted into and became warrants to purchase shares of Issuer's common stock.</footnote>
        <footnote id="F2">(Continued from Footnote 1) On August 29, 2019, following the completion of the Merger, the Issuer effected a reverse stock split at a ratio of one share for every two shares of Issuer common stock outstanding (the &quot;Reverse Stock Split&quot;).</footnote>
        <footnote id="F3">1,386,871 of the reported shares of Issuer common stock were received in connection with the Merger in exchange for shares of DermTech Operations common stock. Each share of DermTech Operations common stock was cancelled and exchanged for the right to receive 1.16150415935026 shares of common stock of Issuer. The shares of common stock of Issuer reported reflect any necessary adjustments to account for the Reverse Stock Split.</footnote>
        <footnote id="F4">Consists of shares held by RTW Master Fund, Ltd. and shares held by RTW Innovation Master Fund, Ltd (collectively, the &quot;RTW Funds&quot;).</footnote>
        <footnote id="F5">The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP (&quot;RTW&quot;), which is deemed the beneficial owner of shares held by the RTW Funds, which are investment funds managed by RTW, and (ii) Roderick Wong, M.D., who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.</footnote>
        <footnote id="F6">On September 25, 2017, the RTW Funds were granted warrants to purchase shares of DermTech Operations common stock. In connection with the Merger, the warrants were cancelled and exchanged for warrants to purchase shares of Issuer common stock, on the same terms and conditions applicable to the original warrants. The warrants are fully vested and exercisable.</footnote>
        <footnote id="F7">These warrants to purchase Issuer common stock were received in connection with the Merger in exchange for warrants to purchase shares of DermTech Operations common stock. Each warrant to purchase one share of DermTech Operations common stock was cancelled and exchanged for the right to receive a warrant to purchase 1.16150415935026 shares of Issuer common stock, on the same terms and conditions applicable to the original warrant. The shares of Issuer common stock exercisable pursuant to the warrants reported reflect any necessary adjustments to account for the Reverse Stock Split.</footnote>
        <footnote id="F8">Consists of shares held directly by RTW Master Fund, Ltd. and shares held directly by RTW Innovation Master Fund, Ltd.</footnote>
        <footnote id="F9">The exercise price reported reflects the Reverse Stock Split.</footnote>
        <footnote id="F10">On March 7, 2018, the RTW Funds were granted warrants to purchase shares of DermTech Operations common stock. In connection with the Merger, the warrants were cancelled and exchanged for warrants to purchase shares of Issuer common stock, on the same terms and conditions applicable to the original warrants. The warrants are fully vested and exercisable.</footnote>
        <footnote id="F11">Consists of shares held directly by RTW Master Fund, Ltd. and shares held directly by RTW Innovation Master Fund, Ltd.</footnote>
    </footnotes>

    <remarks>Exhibit List
Exhibit 24.1 - Power of Attorney
Exhibit 24.2 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Christian Hollweg, attorney-in-fact</signatureName>
        <signatureDate>2019-09-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Christian Hollweg, attorney-in-fact</signatureName>
        <signatureDate>2019-09-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
