0001493152-22-004326.txt : 20220214 0001493152-22-004326.hdr.sgml : 20220214 20220214092759 ACCESSION NUMBER: 0001493152-22-004326 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20211231 FILED AS OF DATE: 20220214 DATE AS OF CHANGE: 20220214 EFFECTIVENESS DATE: 20220214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: RTW INVESTMENTS, LP CENTRAL INDEX KEY: 0001493215 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-16670 FILM NUMBER: 22626189 BUSINESS ADDRESS: STREET 1: 40 10TH AVENUE STREET 2: 7TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 646-597-6980 MAIL ADDRESS: STREET 1: 40 10TH AVENUE STREET 2: 7TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: RTW INVESTMENTS, LLC DATE OF NAME CHANGE: 20100602 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001493215 XXXXXXXX 12-31-2021 12-31-2021 false RTW INVESTMENTS, LP

40 10th Avenue 7th Floor NEW YORK NY 10014

13F HOLDINGS REPORT 028-16670 N Roderick Wong 646-597-6980 /s/ Roderick Wong New York NY 02-14-2022 3 124 6848326 1 0001493219 028-16671 RTW MASTER FUND, LTD. 2 0001776733 028-19525 RTW Innovation Master Fund Ltd. 3 0001785169 028-19571 RTW Venture Fund Ltd INFORMATION TABLE 2 infotable.xml 10X GENOMICS INC CL A COM 88025U109 109408 734481 SH SOLE 1,2,3 734481 0 0 5 01 ACQUISITION CORP COM CL A 33836P105 3861 392000 SH SOLE 1,2,3 392000 0 0 908 DEVICES INC COM 65443P102 1035 40000 SH SOLE 1,2,3 40000 0 0 AADI BIOSCIENCES INC COM 00032Q104 18468 764701 SH SOLE 1,2,3 764701 0 0 ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 61 12229 SH SOLE 1,2,3 12229 0 0 ADICET BIO INC COM 007002108 52885 3023744 SH SOLE 1,2,3 3023744 0 0 ADVERUM BIOTECHNOLOGIES INC COM 00773U108 13296 7554817 SH SOLE 1,2,3 7554817 0 0 AGENUS INC COM NEW 00847G705 18896 5868315 SH SOLE 1,2,3 5868315 0 0 AKOYA BIOSCIENCES INC COM 00974H104 1531 100000 SH SOLE 1,2,3 100000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 335070 1975879 SH SOLE 1,2,3 1975879 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 94106 1990404 SH SOLE 1,2,3 1990404 0 0 APOLLO ENDOSURGERY INC COM 03767D108 2175 258064 SH SOLE 1,2,3 258064 0 0 APYX MEDICAL CORPORATION COM 03837C106 43566 3398279 SH SOLE 1,2,3 3398279 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 9742 2504493 SH SOLE 1,2,3 2504493 0 0 ARGENX SE SPONSORED ADR 04016X101 111167 317447 SH SOLE 1,2,3 317447 0 0 ARROWHEAD PHARMACEUTICALS IN COM 04280A100 22996 346842 SH SOLE 1,2,3 346842 0 0 ARYA SCIENCES ACQU CORP IV CL A G31659108 4958 500000 SH SOLE 1,2,3 500000 0 0 ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 4850 500000 SH SOLE 1,2,3 500000 0 0 ASLAN PHARMACEUTICALS LTD ADS 04522R101 3640 3250000 SH SOLE 1,2,3 3250000 0 0 ATHIRA PHARMA INC COM 04746L104 24842 1906557 SH SOLE 1,2,3 1906557 0 0 AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 46395 5741939 SH SOLE 1,2,3 5741939 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 113977 4795000 SH SOLE 1,2,3 4795000 0 0 AVITA MEDICAL INC COM 05380C102 1278 106667 SH SOLE 1,2,3 106667 0 0 AXONICS INC COM 05465P101 108856 1943864 SH SOLE 1,2,3 1943864 0 0 AXSOME THERAPEUTICS INC COM 05464T104 61159 1618819 SH SOLE 1,2,3 1618819 0 0 BCLS ACQUISITION CORP COM CL A G0904B105 6003 612500 SH SOLE 1,2,3 612500 0 0 BELLUS HEALTH INC NEW COM NEW 07987C204 48043 5968017 SH SOLE 1,2,3 5968017 0 0 BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 52913 869271 SH SOLE 1,2,3 869271 0 0 BIOMEA FUSION INC COM 09077A106 4424 593846 SH SOLE 1,2,3 593846 0 0 BOLT BIOTHERAPEUTICS INC COM 097702104 619 126365 SH SOLE 1,2,3 126365 0 0 BRAINSWAY LTD SPONSORED ADS 10501L106 12338 1602381 SH SOLE 1,2,3 1602381 0 0 C4 THERAPEUTICS INC COM STK 12529R107 80338 2494965 SH SOLE 1,2,3 2494965 0 0 CASTLE BIOSCIENCES INC COM 14843C105 25680 599009 SH SOLE 1,2,3 599009 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 151530 3921579 SH SOLE 1,2,3 3921579 0 0 CEREVEL THERAPEUTICS HLDNG I COM 15678U128 21613 666666 SH SOLE 1,2,3 666666 0 0 CLEARSIDE BIOMEDICAL INC COM 185063104 10467 3806018 SH SOLE 1,2,3 3806018 0 0 CODEX DNA INC COM 192003101 2160 200000 SH SOLE 1,2,3 200000 0 0 CONNECT BIOPHARMA HLDGS LTD ADS 207523101 2318 450000 SH SOLE 1,2,3 450000 0 0 CUTERA INC COM 232109108 57727 1397063 SH SOLE 1,2,3 1397063 0 0 CYTOKINETICS INC COM NEW 23282W605 116739 2561182 SH SOLE 1,2,3 2561182 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 26109 6029700 SH SOLE 1,2,3 6029700 0 0 DERMTECH INC COM 24984K105 49275 3118666 SH SOLE 1,2,3 3118666 0 0 ESSA PHARMA INC COM NEW 29668H708 37448 2637192 SH SOLE 1,2,3 2637192 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 156751 2319138 SH SOLE 1,2,3 2319138 0 0 EXAGEN INC COM 30068X103 9553 821414 SH SOLE 1,2,3 821414 0 0 FULCRUM THERAPEUTICS INC COM 359616109 68405 3866872 SH SOLE 1,2,3 3866872 0 0 GENETRON HLDGS LTD ADS 37186H100 8674 1421894 SH SOLE 1,2,3 1421894 0 0 GH RESEARCH PLC ORDINARY SHARES G3855L106 50602 2168957 SH SOLE 1,2,3 2168957 0 0 GLOBUS MED INC CL A 379577208 120633 1670811 SH SOLE 1,2,3 1670811 0 0 GUARDANT HEALTH INC COM 40131M109 81350 813342 SH SOLE 1,2,3 813342 0 0 IDEAYA BIOSCIENCES INC COM 45166A102 59575 2520076 SH SOLE 1,2,3 2520076 0 0 ILLUMINA INC COM 452327109 186567 490399 SH SOLE 1,2,3 490399 0 0 IMMATICS N.V SHS N44445109 4704 350000 SH SOLE 1,2,3 350000 0 0 IMMUNIC INC COM 4525EP101 16417 1715470 SH SOLE 1,2,3 1715470 0 0 IMMUNOCORE HLDGS PLC ADS 45258D105 42647 1245532 SH SOLE 1,2,3 1245532 0 0 ISOPLEXIS CORP COM 465005106 3354 365000 SH SOLE 1,2,3 365000 0 0 ITEOS THERAPEUTICS INC COM 46565G104 109556 2353015 SH SOLE 1,2,3 2353015 0 0 IVERIC BIO INC COM 46583P102 112402 6722624 SH SOLE 1,2,3 6722624 0 0 JOHNSON & JOHNSON COM 478160104 21405 125127 SH SOLE 1,2,3 125127 0 0 JOUNCE THERAPEUTICS INC COM 481116101 23908 2863198 SH SOLE 1,2,3 2863198 0 0 LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 10825 2327903 SH SOLE 1,2,3 2327903 0 0 LANDOS BIOPHARMA INC COM 515069102 20523 4275722 SH SOLE 1,2,3 4275722 0 0 MACROGENICS INC COM 556099109 63808 3975554 SH SOLE 1,2,3 3975554 0 0 MASIMO CORP COM 574795100 248855 849971 SH SOLE 1,2,3 849971 0 0 MAXCYTE INC COM 57777K106 2802 275000 SH SOLE 1,2,3 275000 0 0 MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 24 33331 SH SOLE 1,2,3 33331 0 0 MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2907 300000 SH SOLE 1,2,3 300000 0 0 MERUS N V COM N5749R100 6240 196231 SH SOLE 1,2,3 196231 0 0 MILESTONE PHARMACEUTICALS IN COM 59935V107 28264 4315102 SH SOLE 1,2,3 4315102 0 0 MIMEDX GROUP INC COM 602496101 1786 295748 SH SOLE 1,2,3 295748 0 0 MINERVA SURGICAL INC COM 60343F106 853 166000 SH SOLE 1,2,3 166000 0 0 MINK THERAPEUTICS INC COM 603693102 1858 416666 SH SOLE 1,2,3 416666 0 0 MIRATI THERAPEUTICS INC COM 60468T105 229056 1561497 SH SOLE 1,2,3 1561497 0 0 MIROMATRIX MED INC COM 60471P108 1313 280000 SH SOLE 1,2,3 280000 0 0 MONTE ROSA THERAPEUTICS INC COM 61225M102 24802 1214572 SH SOLE 1,2,3 1214572 0 0 NANOSTRING TECHNOLOGIES INC COM 63009R109 25508 604029 SH SOLE 1,2,3 604029 0 0 NATERA INC COM 632307104 173914 1862234 SH SOLE 1,2,3 1862234 0 0 NAUTILUS BIOTECHNOLOGY INC COM 63909J108 5698 1100000 SH SOLE 1,2,3 1100000 0 0 NEOGENOMICS INC COM NEW 64049M209 10615 311111 SH SOLE 1,2,3 311111 0 0 NYXOAH S A SHS B6S7WD106 7933 344911 SH SOLE 1,2,3 344911 0 0 OLINK HLDG AB SPONSORED ADS 680710100 18531 1018188 SH SOLE 1,2,3 1018188 0 0 ORASURE TECHNOLOGIES INC COM 68554V108 10032 1154380 SH SOLE 1,2,3 1154380 0 0 OUTSET MED INC COM 690145107 41235 894652 SH SOLE 1,2,3 894652 0 0 OYSTER PT PHARMA INC COM 69242L106 37588 2058504 SH SOLE 1,2,3 2058504 0 0 PENUMBRA INC COM 70975L107 178389 620871 SH SOLE 1,2,3 620871 0 0 PMV PHARMACEUTICALS INC COM 69353Y103 68860 2980960 SH SOLE 1,2,3 2980960 0 0 POINT BIOPHARMA GLOBAL INC COM 730541109 2744 490000 SH SOLE 1,2,3 490000 0 0 PROCEPT BIOROBOTICS CORP COM 74276L105 4855 194136 SH SOLE 1,2,3 194136 0 0 PROMETHEUS BIOSCIENCES INC COM 74349U108 129060 3264031 SH SOLE 1,2,3 3264031 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 56292 7027725 SH SOLE 1,2,3 7027725 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 88914 2599822 SH SOLE 1,2,3 2599822 0 0 PTC THERAPEUTICS INC COM 69366J200 210859 5293966 SH SOLE 1,2,3 5293966 0 0 PULMONX CORP COM 745848101 37349 1164600 SH SOLE 1,2,3 1164600 0 0 PYXIS ONCOLOGY INC COMMON STOCK 747324101 23265 2120760 SH SOLE 1,2,3 2120760 0 0 QUANTERIX CORP COM 74766Q101 29106 686470 SH SOLE 1,2,3 686470 0 0 REGENXBIO INC COM 75901B107 60343 1845366 SH SOLE 1,2,3 1845366 0 0 RELMADA THERAPEUTICS INC COM 75955J402 49258 2186324 SH SOLE 1,2,3 2186324 0 0 RENOVACOR INC *W EXP 99/99/999 75989E114 200 350000 SH SOLE 1,2,3 350000 0 0 RENOVACOR INC COM 75989E106 20386 2647540 SH SOLE 1,2,3 2647540 0 0 RESEARCH ALLIANCE CORP II COM CL A 760873109 6192 637000 SH SOLE 1,2,3 637000 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 344975 15802802 SH SOLE 1,2,3 15802802 0 0 ROIVANT SCIENCES LTD SHS G76279101 8091 802717 SH SOLE 1,2,3 802717 0 0 RXSIGHT INC COM 78349D107 1688 150000 SH SOLE 1,2,3 150000 0 0 SAREPTA THERAPEUTICS INC COM 803607100 52433 582265 SH SOLE 1,2,3 582265 0 0 SCIENCE 37 HOLDINGS INC COM 808644108 49568 3975000 SH SOLE 1,2,3 3975000 0 0 SEMA4 HOLDINGS CORP COM CL A 81663L101 1784 400000 SH SOLE 1,2,3 400000 0 0 SIGHT SCIENCES INC COM 82657M105 20801 1183871 SH SOLE 1,2,3 1183871 0 0 SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1156 100000 SH SOLE 1,2,3 100000 0 0 SOPHIA GENETICS SA ORDINARY SHARES H82027105 4230 300000 SH SOLE 1,2,3 300000 0 0 SPDR S&P 500 ETF TR TR UNIT 78462F103 422590 889739 SH SOLE 1,2,3 889739 0 0 STOKE THERAPEUTICS INC COM 86150R107 87426 3644248 SH SOLE 1,2,3 3644248 0 0 SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 4975 500000 SH SOLE 1,2,3 500000 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 174714 1160734 SH SOLE 1,2,3 1160734 0 0 TANGO THERAPEUTICS INC COM 87583X109 1978 180819 SH SOLE 1,2,3 180819 0 0 TARSUS PHARMACEUTICALS INC COM 87650L103 45306 2013601 SH SOLE 1,2,3 2013601 0 0 TELA BIO INC COM 872381108 17916 1399686 SH SOLE 1,2,3 1399686 0 0 TENAYA THERAPEUTICS INC COM 87990A106 46593 2458750 SH SOLE 1,2,3 2458750 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 290583 435500 SH SOLE 1,2,3 435500 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 115479 1373284 SH SOLE 1,2,3 1373284 0 0 UROGEN PHARMA LTD COM M96088105 8154 857464 SH SOLE 1,2,3 857464 0 0 VENTYX BIOSCIENCES INC COM 92332V107 30818 1551778 SH SOLE 1,2,3 1551778 0 0 VERICEL CORP COM 92346J108 177541 4517570 SH SOLE 1,2,3 4517570 0 0 VINCERX PHARMA INC COM NEW 92731L106 7553 741236 SH SOLE 1,2,3 741236 0 0 ZYMERGEN INC COM 98985X100 468 70000 SH SOLE 1,2,3 70000 0 0