The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 106,926 734,481 SH   SOLE 1,2,3 734,481 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 3,849 392,000 SH   SOLE 1,2,3 392,000 0 0
908 DEVICES INC COM 65443P102 1,301 40,000 SH   SOLE 1,2,3 40,000 0 0
AADI BIOSCIENCES INC COM 00032Q104 21,336 764,701 SH   SOLE 1,2,3 764,701 0 0
ACUTUS MED INC COM 005111109 4,348 491,834 SH   SOLE 1,2,3 491,834 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 16,240 7,483,757 SH   SOLE 1,2,3 7,483,757 0 0
AGENUS INC COM NEW 00847G705 47,641 9,074,438 SH   SOLE 1,2,3 9,074,438 0 0
AKOYA BIOSCIENCES INC COM 00974H104 1,396 100,000 SH   SOLE 1,2,3 100,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 317,836 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APTEVO THERAPEUTICS INC COM NEW 03835L207 4,345 281,402 SH   SOLE 1,2,3 281,402 0 0
APYX MEDICAL CORPORATION COM 03837C106 47,066 3,398,279 SH   SOLE 1,2,3 3,398,279 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 20,306 4,733,323 SH   SOLE 1,2,3 4,733,323 0 0
ARGENX SE SPONSORED ADR 04016X101 42,374 140,311 SH   SOLE 1,2,3 140,311 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 5,025 500,000 SH   SOLE 1,2,3 500,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 4,940 500,000 SH   SOLE 1,2,3 500,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 5,785 3,250,000 SH   SOLE 1,2,3 3,250,000 0 0
ATHIRA PHARMA INC COM 04746L104 17,884 1,906,557 SH   SOLE 1,2,3 1,906,557 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 56,271 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 118,101 4,795,000 SH   SOLE 1,2,3 4,795,000 0 0
AVITA MEDICAL INC COM 05380C102 4,962 280,000 SH   SOLE 1,2,3 280,000 0 0
AXONICS INC COM 05465P101 126,526 1,943,864 SH   SOLE 1,2,3 1,943,864 0 0
AXSOME THERAPEUTICS INC COM 05464T104 53,280 1,616,497 SH   SOLE 1,2,3 1,616,497 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,101 612,500 SH   SOLE 1,2,3 612,500 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 30,431 4,968,017 SH   SOLE 1,2,3 4,968,017 0 0
BERKELEY LTS INC COM 084310101 5,038 257,546 SH   SOLE 1,2,3 257,546 0 0
BIOMEA FUSION INC COM 09077A106 9,877 830,794 SH   SOLE 1,2,3 830,794 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 1,599 126,365 SH   SOLE 1,2,3 126,365 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 12,915 1,602,381 SH   SOLE 1,2,3 1,602,381 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 536 30,000 SH   SOLE 1,2,3 30,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 111,475 2,494,965 SH   SOLE 1,2,3 2,494,965 0 0
CASTLE BIOSCIENCES INC COM 14843C105 39,834 599,009 SH   SOLE 1,2,3 599,009 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 211,044 3,908,947 SH   SOLE 1,2,3 3,908,947 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 19,667 666,666 SH   SOLE 1,2,3 666,666 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 25,241 4,206,765 SH   SOLE 1,2,3 4,206,765 0 0
CODEX DNA INC COM 192003101 2,226 200,000 SH   SOLE 1,2,3 200,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 10,904 450,000 SH   SOLE 1,2,3 450,000 0 0
CUTERA INC COM 232109108 58,616 1,257,862 SH   SOLE 1,2,3 1,257,862 0 0
CVRX INC COM 126638105 2,481 150,000 SH   SOLE 1,2,3 150,000 0 0
CYTOKINETICS INC COM NEW 23282W605 71,480 2,000,000 SH   SOLE 1,2,3 2,000,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 7,131 1,400,939 SH   SOLE 1,2,3 1,400,939 0 0
DERMTECH INC COM 24984K105 100,140 3,118,665 SH   SOLE 1,2,3 3,118,665 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 152,861 7,582,396 SH   SOLE 1,2,3 7,582,396 0 0
ESSA PHARMA INC COM NEW 29668H708 21,098 2,637,192 SH   SOLE 1,2,3 2,637,192 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 166,004 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
EXAGEN INC COM 30068X103 11,171 821,414 SH   SOLE 1,2,3 821,414 0 0
FULCRUM THERAPEUTICS INC COM 359616109 108,758 3,855,291 SH   SOLE 1,2,3 3,855,291 0 0
GENETRON HLDGS LTD ADS 37186H100 23,156 1,671,894 SH   SOLE 1,2,3 1,671,894 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 45,719 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208 128,018 1,670,811 SH   SOLE 1,2,3 1,670,811 0 0
GUARDANT HEALTH INC COM 40131M109 115,677 925,342 SH   SOLE 1,2,3 925,342 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 7,388 750,000 SH   SOLE 1,2,3 750,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 83,257 3,266,255 SH   SOLE 1,2,3 3,266,255 0 0
ILLUMINA INC COM 452327109 195,825 482,791 SH   SOLE 1,2,3 482,791 0 0
IMMATICS N.V SHS N44445109 4,550 350,000 SH   SOLE 1,2,3 350,000 0 0
IMMUNIC INC COM 4525EP101 12,132 1,370,814 SH   SOLE 1,2,3 1,370,814 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 46,172 1,245,532 SH   SOLE 1,2,3 1,245,532 0 0
INMODE LTD SHS M5425M103 19,931 124,999 SH   SOLE 1,2 124,999 0 0
ITEOS THERAPEUTICS INC COM 46565G104 63,531 2,353,015 SH   SOLE 1,2,3 2,353,015 0 0
IVERIC BIO INC COM 46583P102 109,175 6,722,624 SH   SOLE 1,2,3 6,722,624 0 0
JOHNSON & JOHNSON COM 478160104 27,543 170,542 SH   SOLE 1,2,3 170,542 0 0
JOUNCE THERAPEUTICS INC COM 481116101 10,374 1,396,203 SH   SOLE 1,2,3 1,396,203 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 9,288 2,327,903 SH   SOLE 1,2,3 2,327,903 0 0
LANDOS BIOPHARMA INC COM 515069102 62,426 4,275,722 SH   SOLE 1,2,3 4,275,722 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 9,555 975,000 SH   SOLE 1,2,3 975,000 0 0
MACROGENICS INC COM 556099109 83,248 3,975,554 SH   SOLE 1,2,3 3,975,554 0 0
MASIMO CORP COM 574795100 225,377 832,540 SH   SOLE 1,2,3 832,540 0 0
MAXCYTE INC COM 57777K106 3,358 275,000 SH   SOLE 1,2,3 275,000 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 24 33,331 SH   SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,925 300,000 SH   SOLE 1,2,3 300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 24,639 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MIMEDX GROUP INC COM 602496101 1,792 295,748 SH   SOLE 1,2,3 295,748 0 0
MIRATI THERAPEUTICS INC COM 60468T105 264,044 1,492,532 SH   SOLE 1,2,3 1,492,532 0 0
MIROMATRIX MED INC COM 60471P108 1,949 280,000 SH   SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 26,005 1,214,572 SH   SOLE 1,2,3 1,214,572 0 0
MONTES ARCHIMEDES ACQUISITIO COM CL A 612657106 3,160 400,000 SH   SOLE 1,2,3 400,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 38,601 804,029 SH   SOLE 1,2,3 804,029 0 0
NATERA INC COM 632307104 207,527 1,862,234 SH   SOLE 1,2,3 1,862,234 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 6,588 1,100,000 SH   SOLE 1,2,3 1,100,000 0 0
NEOGENOMICS INC COM NEW 64049M209 14,873 311,111 SH   SOLE 1,2,3 311,111 0 0
NYXOAH S A SHS B6S7WD106 10,087 344,911 SH   SOLE 1,2,3 344,911 0 0
OLINK HLDG AB SPONSORED ADS 680710100 31,966 1,318,188 SH   SOLE 1,2,3 1,318,188 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 13,286 1,174,722 SH   SOLE 1,2,3 1,174,722 0 0
OUTSET MED INC COM 690145107 44,232 894,652 SH   SOLE 1,2,3 894,652 0 0
OYSTER PT PHARMA INC COM 69242L106 22,055 1,861,209 SH   SOLE 1,2,3 1,861,209 0 0
PENUMBRA INC COM 70975L107 102,654 385,194 SH   SOLE 1,2,3 385,194 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 24,134 809,863 SH   SOLE 1,2,3 809,863 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 3,768 490,000 SH   SOLE 1,2,3 490,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 7,406 194,136 SH   SOLE 1,2,3 194,136 0 0
PROFOUND MED CORP COM NEW 74319B502 1,788 122,098 SH   SOLE 1,2,3 122,098 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 77,390 3,264,031 SH   SOLE 1,2,3 3,264,031 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 53,929 6,443,113 SH   SOLE 1,2,3 6,443,113 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 31,075 1,753,695 SH   SOLE 1,2,3 1,753,695 0 0
PTC THERAPEUTICS INC COM 69366J200 196,988 5,293,966 SH   SOLE 1,2,3 5,293,966 0 0
PULMONX CORP COM 745848101 41,902 1,164,600 SH   SOLE 1,2,3 1,164,600 0 0
REGENXBIO INC COM 75901B107 77,358 1,845,366 SH   SOLE 1,2,3 1,845,366 0 0
RELMADA THERAPEUTICS INC COM 75955J402 40,312 1,538,026 SH   SOLE 1,2,3 1,538,026 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 224 350,000 SH   SOLE 1,2,3 350,000 0 0
RENOVACOR INC COM 75989E106 19,254 2,187,540 SH   SOLE 1,2,3 2,187,540 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,274 637,000 SH   SOLE 1,2,3 637,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 469,601 15,802,802 SH   SOLE 1,2,3 15,802,802 0 0
RXSIGHT INC COM 78349D107 1,901 150,000 SH   SOLE 1,2,3 150,000 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 2,936 400,000 SH   SOLE 1,2,3 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 5,336 161,612 SH   SOLE 1,2,3 161,612 0 0
SIGHT SCIENCES INC COM 82657M105 29,144 1,283,871 SH   SOLE 1,2,3 1,283,871 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,119 100,000 SH   SOLE 1,2,3 100,000 0 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 5,259 300,000 SH   SOLE 1,2,3 300,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 374,749 873,255 SH   SOLE 1,2,3 873,255 0 0
STOKE THERAPEUTICS INC COM 86150R107 92,710 3,644,248 SH   SOLE 1,2,3 3,644,248 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 5,025 500,000 SH   SOLE 1,2,3 500,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 138,568 1,160,734 SH   SOLE 1,2,3 1,160,734 0 0
TANGO THERAPEUTICS INC COM 87583X109 7,758 600,000 SH   SOLE 1,2,3 600,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 43,393 2,013,601 SH   SOLE 1,2,3 2,013,601 0 0
TELA BIO INC COM 872381108 19,010 1,391,619 SH   SOLE 1,2,3 1,391,619 0 0
TENAYA THERAPEUTICS INC COM 87990A106 48,581 2,458,750 SH   SOLE 1,2,3 2,458,750 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 237,673 416,000 SH   SOLE 1,2,3 416,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 1,976 18,473 SH   SOLE 1,2,3 18,473 0 0
UROGEN PHARMA LTD COM M96088105 14,423 857,464 SH   SOLE 1,2,3 857,464 0 0
VERICEL CORP COM 92346J108 220,457 4,517,570 SH   SOLE 1,2,3 4,517,570 0 0
VINCERX PHARMA INC COM NEW 92731L106 12,127 749,999 SH   SOLE 1,2,3 749,999 0 0
ZYMERGEN INC COM 98985X100 922 70,000 SH   SOLE 1,2,3 70,000 0 0