Managing Partner

0001493152-21-019742.txt : 20210813 0001493152-21-019742.hdr.sgml : 20210813 20210813163120 ACCESSION NUMBER: 0001493152-21-019742 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20210630 FILED AS OF DATE: 20210813 DATE AS OF CHANGE: 20210813 EFFECTIVENESS DATE: 20210813 FILER: COMPANY DATA: COMPANY CONFORMED NAME: RTW INVESTMENTS, LP CENTRAL INDEX KEY: 0001493215 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-16670 FILM NUMBER: 211172656 BUSINESS ADDRESS: STREET 1: 40 10TH AVENUE STREET 2: 7TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 646-597-6980 MAIL ADDRESS: STREET 1: 40 10TH AVENUE STREET 2: 7TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: RTW INVESTMENTS, LLC DATE OF NAME CHANGE: 20100602 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001493215 XXXXXXXX 06-30-2021 06-30-2021 false RTW INVESTMENTS, LP

40 10TH AVENUE 7TH FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-16670 N Roderick Wong Managing Partner 646-597-6980 /s/ Roderick Wong New York NY 08-13-2021 3 113 6627025 1 0001493219 028-16671 RTW MASTER FUND, LTD. 2 0001776733 028-19525 RTW Innovation Master Fund Ltd. 3 0001785169 028-19571 RTW Venture Fund Ltd INFORMATION TABLE 2 infotable.xml 10X GENOMICS INC CL A COM 88025U109 143826 734481 SH SOLE 1,2,3 734481 0 0 5 01 ACQUISITION CORP COM CL A 33836P105 3908 392000 SH SOLE 1,2,3 392000 0 0 908 DEVICES INC COM 65443P102 1550 40000 SH SOLE 1,2,3 40000 0 0 ACUTUS MED INC COM 005111109 7672 451834 SH SOLE 1,2,3 451834 0 0 ADVERUM BIOTECHNOLOGIES INC COM 00773U108 25753 7357917 SH SOLE 1,2,3 7357917 0 0 AGENUS INC COM NEW 00847G705 62790 11437238 SH SOLE 1,2,3 11437238 0 0 AKOYA BIOSCIENCES INC COM 00974H104 1934 100000 SH SOLE 1,2,3 100000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 285364 1683362 SH SOLE 1,2,3 1683362 0 0 APTEVO THERAPEUTICS INC COM NEW 03835L207 6312 281402 SH SOLE 1,2,3 281402 0 0 APYX MEDICAL CORPORATION COM 03837C106 34964 3391279 SH SOLE 1,2,3 3391279 0 0 ARBUTUS BIOPHARMA CORP COM 03879J100 18114 5978355 SH SOLE 1,2,3 5978355 0 0 ARGENX SE SPONSORED ADR 04016X101 9560 31752 SH SOLE 1,2 31752 0 0 ARYA SCIENCES ACQU CORP IV CL A G31659108 5360 500000 SH SOLE 1,2,3 500000 0 0 ASLAN PHARMACEUTICALS LTD ADS 04522R101 10725 3250000 SH SOLE 1,2,3 3250000 0 0 ATHIRA PHARMA INC COM 04746L104 19523 1906557 SH SOLE 1,2,3 1906557 0 0 AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 38643 5741939 SH SOLE 1,2,3 5741939 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 98716 3995000 SH SOLE 1,2,3 3995000 0 0 AVITA MEDICAL INC COM 05380C102 5746 280000 SH SOLE 1,2,3 280000 0 0 AXONICS INC COM 05465P101 123260 1943864 SH SOLE 1,2,3 1943864 0 0 AXSOME THERAPEUTICS INC COM 05464T104 109049 1616497 SH SOLE 1,2,3 1616497 0 0 AZIYO BIOLOGICS INC COM CL A 05479K106 1201 125000 SH SOLE 1,2,3 125000 0 0 BCLS ACQUISITION CORP COM CL A G0904B105 6450 612500 SH SOLE 1,2,3 612500 0 0 BCTG ACQUISITION CORP COM 05492W103 6828 600000 SH SOLE 1,2,3 600000 0 0 BELLUS HEALTH INC NEW COM NEW 07987C204 15441 4968017 SH SOLE 1,2,3 4968017 0 0 BERKELEY LTS INC COM 084310101 11541 257546 SH SOLE 1,2,3 257546 0 0 BIODESIX INC COM 09075X108 1651 125000 SH SOLE 1,2,3 125000 0 0 BIOMEA FUSION INC COM 09077A106 12270 830794 SH SOLE 1,2,3 830794 0 0 BOLT BIOTHERAPEUTICS INC COM 097702104 1954 126365 SH SOLE 1,2,3 126365 0 0 BRAINSWAY LTD SPONSORED ADS 10501L106 16342 1602181 SH SOLE 1,2,3 1602181 0 0 BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 884 30000 SH SOLE 1,2,3 30000 0 0 C4 THERAPEUTICS INC COM STK 12529R107 81327 2149228 SH SOLE 1,2,3 2149228 0 0 CASTLE BIOSCIENCES INC COM 14843C105 58591 799009 SH SOLE 1,2,3 799009 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 130715 3908947 SH SOLE 1,2,3 3908947 0 0 CEREVEL THERAPEUTICS HLDNG I COM 15678U128 12810 500000 SH SOLE 1,2,3 500000 0 0 CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 2398 166666 SH SOLE 1,2,3 166666 0 0 CHARDAN HEALTHCR ACQSTN 2 CO COM 15957T107 8299 837540 SH SOLE 1,2,3 837540 0 0 CHARDAN HEALTHCR ACQSTN 2 CO UNIT 99/99/9999 15957T206 3644 350000 SH SOLE 1,2,3 350000 0 0 CLEARSIDE BIOMEDICAL INC COM 185063104 20487 4206765 SH SOLE 1,2,3 4206765 0 0 CODEX DNA INC COM 192003101 4400 200000 SH SOLE 1,2,3 200000 0 0 CONNECT BIOPHARMA HLDGS LTD ADS 207523101 8789 450000 SH SOLE 1,2,3 450000 0 0 CUTERA INC COM 232109108 35342 720817 SH SOLE 1,2,3 720817 0 0 CVRX INC COM 126638105 4200 150000 SH SOLE 1,2,3 150000 0 0 CYTOKINETICS INC COM NEW 23282W605 39580 2000000 SH SOLE 1,2,3 2000000 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 8868 1400939 SH SOLE 1,2,3 1400939 0 0 DERMTECH INC COM 24984K105 129643 3118665 SH SOLE 1,2,3 3118665 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 280716 7521859 SH SOLE 1,2,3 7521859 0 0 ESSA PHARMA INC COM NEW 29668H708 87250 3053919 SH SOLE 1,2,3 3053919 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 202554 2319138 SH SOLE 1,2,3 2319138 0 0 EXAGEN INC COM 30068X103 12313 821414 SH SOLE 1,2,3 821414 0 0 FULCRUM THERAPEUTICS INC COM 359616109 33591 3205291 SH SOLE 1,2,3 3205291 0 0 GENETRON HLDGS LTD ADS 37186H100 36618 1818162 SH SOLE 1,2,3 1818162 0 0 GH RESEARCH PLC ORDINARY SHARES G3855L106 42661 2168957 SH SOLE 1,2,3 2168957 0 0 GLOBUS MED INC CL A 379577208 129538 1670811 SH SOLE 1,2,3 1670811 0 0 GUARDANT HEALTH INC COM 40131M109 114038 918253 SH SOLE 1,2,3 918253 0 0 HELIX ACQUISITION CORP COM CL A G4444C102 7763 750000 SH SOLE 1,2,3 750000 0 0 IDEAYA BIOSCIENCES INC COM 45166A102 68559 3266255 SH SOLE 1,2,3 3266255 0 0 ILLUMINA INC COM 452327109 228462 482791 SH SOLE 1,2,3 482791 0 0 IMMATICS N.V SHS N44445109 4064 350000 SH SOLE 1,2,3 350000 0 0 IMMUNIC INC COM 4525EP101 11289 920814 SH SOLE 1,2,3 920814 0 0 IMMUNOCORE HLDGS PLC ADS 45258D105 47888 1245532 SH SOLE 1,2,3 1245532 0 0 INMODE LTD SHS M5425M103 11835 124999 SH SOLE 1,2 124999 0 0 ITAMAR MED LTD SPONSORED ADS 465437101 6326 268609 SH SOLE 1,2,3 268609 0 0 ITEOS THERAPEUTICS INC 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THERAPEUTICS INC COM 60468T105 235435 1457532 SH SOLE 1,2,3 1457532 0 0 MIROMATRIX MED INC COM 60471P108 3262 280000 SH SOLE 1,2,3 280000 0 0 MONTE ROSA THERAPEUTICS INC COM 61225M102 25228 1214572 SH SOLE 1,2,3 1214572 0 0 NANOSTRING TECHNOLOGIES INC COM 63009R109 52093 804029 SH SOLE 1,2,3 804029 0 0 NATERA INC COM 632307104 194390 1712234 SH SOLE 1,2,3 1712234 0 0 NAUTILUS BIOTECHNOLOGY INC COM 63909J108 10383 1100000 SH SOLE 1,2,3 1100000 0 0 NEOGENOMICS INC COM NEW 64049M209 13139 311111 SH SOLE 1,2,3 311111 0 0 OLINK HLDG AB SPONSORED ADS 680710100 42963 1248188 SH SOLE 1,2,3 1248188 0 0 OUTSET MED INC COM 690145107 36843 737152 SH SOLE 1,2,3 737152 0 0 OYSTER PT PHARMA INC COM 69242L106 31994 1861209 SH SOLE 1,2,3 1861209 0 0 PERSONALIS INC COM 71535D106 3226 127501 SH SOLE 1,2 127501 0 0 PMV PHARMACEUTICALS INC COM 69353Y103 16538 484133 SH SOLE 1,2,3 484133 0 0 PROFOUND MED CORP COM NEW 74319B502 1998 122098 SH SOLE 1,2,3 122098 0 0 PROGENITY INC COM 74319F107 357 100000 SH SOLE 1,2,3 100000 0 0 PROMETHEUS BIOSCIENCES INC COM 74349U108 75989 3264031 SH SOLE 1,2,3 3264031 0 0 PROQR THRAPEUTICS N V SHS EURO N71542109 43427 6443113 SH SOLE 1,2,3 6443113 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 157412 3507390 SH SOLE 1,2,3 3507390 0 0 PTC THERAPEUTICS INC COM 69366J200 223776 5293966 SH SOLE 1,2,3 5293966 0 0 PULMONX CORP COM 745848101 49838 1129600 SH SOLE 1,2,3 1129600 0 0 QUIDEL CORP COM 74838J101 112558 878533 SH SOLE 1,2,3 878533 0 0 REGENXBIO INC COM 75901B107 68288 1757743 SH SOLE 1,2,3 1757743 0 0 RELMADA THERAPEUTICS INC COM 75955J402 49232 1538026 SH SOLE 1,2,3 1538026 0 0 RESEARCH ALLIANCE CORP II COM CL A 760873109 6459 637000 SH SOLE 1,2,3 637000 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 663920 14990286 SH SOLE 1,2,3 14990286 0 0 SCHOLAR ROCK HLDG CORP COM 80706P103 4671 161612 SH SOLE 1,2,3 161612 0 0 SINGULAR GENOMICS SYSTEMS IN COM 82933R100 2748 100000 SH SOLE 1,2,3 100000 0 0 SPDR S&P 500 ETF TR TR UNIT 78462F103 426457 996255 SH SOLE 1,2,3 996255 0 0 STOKE THERAPEUTICS INC COM 86150R107 122665 3644248 SH SOLE 1,2,3 3644248 0 0 SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 5005 500000 SH SOLE 1,2,3 500000 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 111758 1147408 SH SOLE 1,2,3 1147408 0 0 TARSUS PHARMACEUTICALS INC COM 87650L103 58354 2013601 SH SOLE 1,2,3 2013601 0 0 TELA BIO INC COM 872381108 22432 1392434 SH SOLE 1,2,3 1392434 0 0 THERAPEUTICS ACQUISITION COR COM CL A 88339T103 5034 490000 SH SOLE 1,2,3 490000 0 0 TRILLIUM THERAPEUTICS INC COM NEW 89620X506 20286 2091389 SH SOLE 1,2,3 2091389 0 0 TWIST BIOSCIENCE CORP COM 90184D100 2462 18473 SH SOLE 1,2,3 18473 0 0 VERICEL CORP COM 92346J108 237172 4517570 SH SOLE 1,2,3 4517570 0 0 VINCERX PHARMA INC COM NEW 92731L106 9742 749999 SH SOLE 1,2,3 749999 0 0 ZYMERGEN INC COM 98985X100 2801 70000 SH SOLE 1,2,3 70000 0 0