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    <nameOfIssuer>Abeona Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00289Y107</cusip>
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    <nameOfIssuer>Achillion Pharmaceuticals Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00448Q201</cusip>
    <value>17891</value>
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    <nameOfIssuer>Agenus Inc</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>00847G705</cusip>
    <value>29737</value>
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    <nameOfIssuer>Alnylam Pharmaceuticals Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>02043Q107</cusip>
    <value>64275</value>
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    <nameOfIssuer>Arrowhead Pharmaceuticals Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04280A100</cusip>
    <value>8208</value>
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    <nameOfIssuer>Atara Biotherapeutics Inc.</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>46513107</cusip>
    <value>9799</value>
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    <nameOfIssuer>Audentes Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>05070R104</cusip>
    <value>356</value>
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    <nameOfIssuer>Avexis Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>05366U100</cusip>
    <value>34039</value>
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    <nameOfIssuer>Barclays Bank Plc</nameOfIssuer>
    <titleOfClass>ETN DJUBSCOFFE38</titleOfClass>
    <cusip>06739H297</cusip>
    <value>4018</value>
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    <nameOfIssuer>BioCryst Pharmaceuticals Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09058V103</cusip>
    <value>18542</value>
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    <nameOfIssuer>Biopharmx Corp</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09072X101</cusip>
    <value>389</value>
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    <nameOfIssuer>bluebird bio Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09609G100</cusip>
    <value>5947</value>
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    <nameOfIssuer>Celldex Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>15117B103</cusip>
    <value>5022</value>
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    <nameOfIssuer>Corium International Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>21887L107</cusip>
    <value>5888</value>
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    <nameOfIssuer>Dicerna Pharmaceuticals Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>253031108</cusip>
    <value>11918</value>
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    <nameOfIssuer>Five Prime Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>33830X104</cusip>
    <value>2312</value>
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    <nameOfIssuer>Global Blood Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>37890U108</cusip>
    <value>2206</value>
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    <nameOfIssuer>Heron Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>427746102</cusip>
    <value>6664</value>
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    <nameOfIssuer>Incyte Corp</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45337C102</cusip>
    <value>18024</value>
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    <nameOfIssuer>Invuity Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>46187J205</cusip>
    <value>5390</value>
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    <nameOfIssuer>La Jolla Pharmaceutical Co</nameOfIssuer>
    <titleOfClass>COM PAR $.0001 2</titleOfClass>
    <cusip>503459604</cusip>
    <value>27838</value>
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    <nameOfIssuer>Masimo Corp</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>574795100</cusip>
    <value>1541</value>
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    <nameOfIssuer>Medicines Co</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
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    <value>4642</value>
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    <nameOfIssuer>Mirati Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>60468T105</cusip>
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    <cusip>56400P201</cusip>
    <value>272</value>
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    <nameOfIssuer>Natera Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>632307104</cusip>
    <value>352</value>
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    <nameOfIssuer>Nivalis Therapeutics Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>65481J109</cusip>
    <value>244</value>
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    <nameOfIssuer>Omeros Corp</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
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    <nameOfIssuer>Oxford Immunotec Global PLC</nameOfIssuer>
    <titleOfClass>ORD SHS</titleOfClass>
    <cusip>G6855A103</cusip>
    <value>2963</value>
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    <nameOfIssuer>Regenxbio Inc</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>75901B107</cusip>
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    <nameOfIssuer>Sensus Healthcare Inc Cmn</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>81728J109</cusip>
    <value>773</value>
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    <nameOfIssuer>SPDR Gold Trust</nameOfIssuer>
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    <cusip>78463V107</cusip>
    <value>10428</value>
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    <nameOfIssuer>Tactile Systems Technology Inc Cmn</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>87357P100</cusip>
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    <nameOfIssuer>Viveve Medical Inc</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
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    <value>6060</value>
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