SC 13G

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934*

BioCryst Pharmaceuticals, Inc.

(Name of Issuer)

Common Stock, $0.01 par value per share

(Title of Class of Securities)

09058V103

(CUSIP Number)

August 18, 2016

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

[  ] Rule 13d-1(b)

[X] Rule 13d-1(c)

[  ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 09058V103

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	RTW Investments, LLC
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [  ]
		(b) [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	3,701,460
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	3,701,460
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	3,701,460
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[  ]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	5.02%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	OO, IA

CUSIP No. 09058V103

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	RTW Master Fund, Ltd.
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [  ]
		(b) [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	Cayman Islands
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	3,701,460
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	3,701,460
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	3,701,460
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[  ]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	5.02%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	CO

CUSIP No. 09058V103

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	Roderick Wong
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [  ]
		(b) [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	United States of America
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	3,701,460
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	3,701,460
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	3,701,460
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[  ]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	5.02%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	IN, HC

Item 1.	(a).	Name of Issuer: BioCryst Pharmaceuticals, Inc.
	(b).	Address of issuer’s principal executive offices:
		4505 Emperor Blvd., Suite 200
		Durham, NC 27703
Item 2.	(a).	Name of person filing:
		RTW Investments, LLC
		RTW Master Fund, Ltd.
		Roderick Wong
	(b).	Address or principal business office or, if none, residence:
		RTW Investments, LLC 250 West 55th Street, 16th Floor
		Suite A
		New York, New York 10019
		RTW Master Fund, Ltd.
		c/o Intertrust Corporate Services (Cayman) Limited
		190 Elgin Avenue, George Town Grand Cayman KY1-9001, Cayman Islands
		Grand Cayman KY1-9001, Cayman Islands
		Roderick Wong
		c/o RTW Investments, LLC 250 West 55th Street, 16th Floor
		Suite A
		New York, New York 10019
	(c).	Citizenship:
		RTW Investments, LLC – Delaware
		RTW Master Fund, Ltd. – Cayman Islands
		Roderick Wong – United States of America
	(d).	Title of class of securities:
		Common Stock, $0.01 par value per share
	(e).	CUSIP No.:
		09058V103

Item 3.	If This Statement is filed pursuant to §§.240.13d-1(b) or 240.13d-2(b), or (c), check whether the person filing is a
	N/A
Item 4.	Ownership.
	Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a)	Amount beneficially owned:
	RTW Investments, LLC – 3,701,460*
	RTW Master Fund, Ltd. – 3,701,460*
	Roderick Wong – 3,701,460*
(b)	Percent of class:
	RTW Investments, LLC – 5.02%*
	RTW Master Fund, Ltd. – 5.02%*
	Roderick Wong – 5.02%*

(c) Number of shares as to which the person has:
	(i)	Sole power to vote or to direct the vote
		RTW Investments, LLC – 0
		RTW Master Fund, Ltd. – 0
		Roderick Wong – 0
	(ii)	Shared power to vote or to direct the vote
		RTW Investments, LLC – 3,701,460*
		RTW Master Fund, Ltd. – 3,701,460*
		Roderick Wong – 3,701,460*
	(iii)	Sole power to dispose or to direct the disposition of
		RTW Investments, LLC – 0
		RTW Master Fund, Ltd. – 0
		Roderick Wong – 0
	(iv)	Shared power to dispose or to direct the disposition of
		RTW Investments, LLC – 3,701,460*
		RTW Master Fund, Ltd. – 3,701,460*
		Roderick Wong – 3,701,460*

* The shares of common stock, $.01 par value (the “Shares”), of BioCryst Pharmaceuticals, Inc. (the “Company”), reported herein are held by RTW MASTER FUND, LTD. (the “Fund”), which is managed by RTW INVESTMENTS, LLC (the “Adviser”). The Adviser, in its capacity as the investment manager of the Fund, has the power to vote and direct the disposition of all Shares held by the Fund. Accordingly, for the purposes of Reg. Section 240.13d-3, the Adviser may be deemed to beneficially own an aggregate of 3,701,460 Shares, or 5.02% of Shares deemed issued and outstanding as of July 31, 2016. Roderick Wong is the Managing Member of the Adviser. The beneficial ownership percentage reported herein is based on 73,700,542 voting Shares issued and outstanding as of July 31, 2016, as disclosed in the Company’s Quarterly Report for the quarter ended June 30, 2016, as filed with the Securities and Exchange Commission on August 8, 2016. This report shall not be deemed an admission that the Adviser, the Fund or any other person is the beneficial owner of the securities reported herein for purposes of Section 13 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Item 5.	Ownership of Five Percent or Less of a Class.
	If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [_].
	N/A
Item 6.	Ownership of More Than Five Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
	N/A
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent
	Holding Company or Control Person.
	If a parent holding company or control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company or control person has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
	N/A
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identity of each member of the group.
	N/A
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5.
	N/A
Item 10.	Certification.
	By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: August 26, 2016

RTW Investments, LLC
By:	/s/ Roderick Wong
	Roderick Wong, Managing Member
RTW Master Fund, Ltd.
By:	/s/ Roderick Wong
	Roderick Wong, Director
Roderick Wong
By:	/s/ Roderick Wong
	Roderick Wong, Individually

The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative’s authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature.

Note. Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See s.240.13d-7 for other parties for whom copies are to be sent.

Attention. Intentional misstatements or omissions of fact constitute Federal criminal violations (see 18 U.S.C. 1001).

EX-1

Exhibit 1

Joint Filing Statement Statement

Pursuant to Rule 13d-1(k)(1)

The undersigned hereby consent and agree to file a joint statement on Schedule 13G under the Securities Exchange Act of 1934, as amended, with respect to the Common stock, $.01 par value, of BioCryst Pharmaceuticals, Inc. beneficially owned by them, together with any or all amendments thereto, when and if appropriate. The parties hereto further consent and agree to file this Joint Filing Statement pursuant to Rule13d-1(k)(1)(iii) as an exhibit to Schedule 13G, thereby incorporating the same into such Schedule13G.

This Joint Filing Statement may be terminated by any of the undersigned upon written notice or such lesser period of notice as the undersigned may mutually agree.

Dated: August 26, 2016

RTW Investments, LLC
By:	/s/ Roderick Wong
	Roderick Wong, Managing Member
RTW Master Fund, Ltd.
By:	/s/ Roderick Wong
	Roderick Wong, Director
Roderick Wong
By:	/s/ Roderick Wong
	Roderick Wong, Individually