X0508 4 2025-04-29 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001493215 RTW INVESTMENTS, LP 40 10TH AVENUE, 7TH FLOOR NEW YORK NY 10014 0 0 1 0 0001493280 WONG RODERICK 40 10TH AVENUE, 7TH FLOOR NEW YORK NY 10014 0 0 1 0 0 Common Stock 2025-04-29 4 P 0 50000 2.53 A 8256163 I Please see footnote Held by certain affiliated funds managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The reporting persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein. /s/ Roderick Wong, for RTW Investments, LP, By: Roderick Wong, M.D., Managing Partner 2025-04-29 /s/ Roderick Wong, By: Roderick Wong, M.D. 2025-04-29