<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001187342</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001492691</issuerCik>
      <issuerName>Knight-Swift Transportation Holdings Inc.</issuerName>
      <secFileNumber>001-35007</secFileNumber>
      <issuerAddress>
        <com:street1>2200 SOUTH 75TH AVENUE</com:street1>
        <com:city>PHOENIX</com:city>
        <com:stateOrCountry>AZ</com:stateOrCountry>
        <com:zipCode>85043</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>602-269-9700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>KNIGHT KEVIN P</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Clearing Services</name>
        <address>
          <com:street1>1 N. Jefferson Ave.</com:street1>
          <com:city>St. louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>20000</noOfUnitsSold>
      <aggregateMarketValue>1025375.78</aggregateMarketValue>
      <noOfUnitsOutstanding>161864000</noOfUnitsOutstanding>
      <approxSaleDate>08/05/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/25/1994</acquiredDate>
      <natureOfAcquisitionTransaction>IPO</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
      <paymentDate>10/25/1994</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin P.  Knight</name>
        <address>
          <com:street1>2200 South 75th Avenue</com:street1>
          <com:city>Phoenix</com:city>
          <com:stateOrCountry>AZ</com:stateOrCountry>
          <com:zipCode>85043</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Shares of KNX </securitiesClassTitle>
      <saleDate>08/02/2024</saleDate>
      <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
      <grossProceeds>1509716.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Shares sold by the Kevin &amp; Sydney Knight R L Trust, Kevin Knight is a TTEE of the trust and an officer &amp; director of the issuer.</remarks>
    <noticeSignature>
      <noticeDate>08/05/2024</noticeDate>
      <signature>Kevin P. Knight</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
