<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001233274</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001492691</issuerCik>
      <issuerName>Knight-Swift Transportation Holdings Inc.</issuerName>
      <secFileNumber>001-35007</secFileNumber>
      <issuerAddress>
        <com:street1>2002 West Wahalla Lane</com:street1>
        <com:city>PHOENIX</com:city>
        <com:stateOrCountry>AZ</com:stateOrCountry>
        <com:zipCode>85027</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>602-269-2000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SYNOWICKI ROBERT E JR</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab Corp</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2627</noOfUnitsSold>
      <aggregateMarketValue>140912.00</aggregateMarketValue>
      <noOfUnitsOutstanding>161864000</noOfUnitsOutstanding>
      <approxSaleDate>08/16/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/14/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Awards</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2627</amountOfSecuritiesAcquired>
      <paymentDate>05/14/2024</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>08/16/2024</noticeDate>
      <signature>Robert E. Synowicki Jr.</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
