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Stock-Based Compensation - Summary of Stock Option Activity (Detail) - 2006 and 2014 Stock Option Plans and Inducement Plan [Member] - Stock Options [Member] - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Share-Based Compensation      
Number of Shares Outstanding, beginning of the period 197,171    
Number of Shares, Granted 33,520    
Number of Shares, Exercised 0 (1,566)  
Number of Shares, Forfeited (25,608)    
Number of Shares, Cancelled (11,863)    
Number of Shares Outstanding, end of the period 193,220   197,171
Number of Shares, Exercisable 127,461    
Number of Shares, Vested or expected to vest 182,864    
Weighted-Average Exercise Price Per Share Outstanding, beginning of the period $ 143.96    
Weighted-Average Exercise Price Per Share, Granted 21.50    
Weighted-Average Exercise Price Per Share, Forfeited 42.64    
Weighted-Average Exercise Price Per Share, Cancelled 119.60    
Weighted-Average Exercise Price Per Share Outstanding, end of the period 137.64   $ 143.96
Weighted-Average Exercise Price Per Share, Exercisable 186.38    
Weighted-Average Exercise Price Per Share, Vested or expected to vest $ 143.27    
Weighted-Average Remaining Contractual Term, Outstanding 6 years 9 months 10 days   7 years 1 month 2 days
Weighted-Average Remaining Contractual Term, Exercisable 5 years 10 months 24 days    
Weighted-Average Remaining Contractual Term, Vested or expected to vest 6 years 7 months 28 days    
Aggregate Intrinsic Value, Outstanding     $ 51