Leases - Additional Information (Detail) - USD ($)		1 Months Ended					3 Months Ended
	Nov. 30, 2014	Sep. 30, 2021	Oct. 31, 2020	Sep. 30, 2017	Apr. 30, 2015	Nov. 30, 2014	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2019
Leases [Line Items]
Operating lease right-of-use assets							$ 9,472,000	$ 9,766,000
License Agreement [Member] | Operating Lease Entered into November 2014 [Member] | Office Space [Member]
Leases [Line Items]
Lease expiration date				Dec. 31, 2021	Dec. 31, 2017
Security deposit	$ 50,000					$ 50,000
Lease termination date	Dec. 31, 2021
Office Space, Laboratory Space, and Equipment [Member]
Leases [Line Items]
Operating lease right-of-use assets							0
Lease liabilities							$ 0
Maximum lease period to not recognize right of use assets or lease liabilities							12 months
Laboratory Space [Member] | Operating Lease Entered into November 2014 [Member]
Leases [Line Items]
Lease expiration date			Oct. 31, 2025
Security deposit							$ 130,977		$ 281,000
Term of lease	6 years					6 years
Space build-out costs paid	$ 1,400,000					$ 1,400,000
Space build-out costs						$ 2,200,000
Security deposit received from landlord								$ 281,000
Office, Research, Laboratory and Manufacturing Space [Member] | Operating Leases Entered Into September 2021 [Member]
Leases [Line Items]
Operating lease right-of-use assets							0
Lease liabilities							0
Security deposit							$ 1,000,000.0
Term of lease		126 months
Anticipated lease commencement year		2022