Nature of Business - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended
	Feb. 28, 2022	Mar. 31, 2022	May 05, 2022	Dec. 31, 2021	Nov. 05, 2021	Mar. 31, 2021	Dec. 31, 2020
Nature Of Business [Line Items]
Cash, cash equivalents, marketable securities and restricted cash		$ 20,500
Accumulated deficit		488,711		$ 472,216
Stockholders' deficit		$ 25,651		$ 12,903		$ 566	$ (8,726)
Debt maturity date		Dec. 30, 2023
Minimum price of common stock for continued listing					$ 1.00
Subsequent Event [Member]
Nature Of Business [Line Items]
Minimum price of common stock for continued listing			$ 1.00
Maximum [Member]
Nature Of Business [Line Items]
Stock trading price		$ 1.00
Minimum [Member]
Nature Of Business [Line Items]
Regain compliance by increasing the stock price		$ 1.00
Term Loan Agreement [Member] | CRG [Member]
Nature Of Business [Line Items]
Minimum cash balance		$ 5,000
Debt maturity date	Dec. 30, 2023	Dec. 30, 2023