Nature of Business - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Nov. 05, 2021	Dec. 31, 2020	Dec. 31, 2019
Nature Of Business [Line Items]
Cash, cash equivalents, marketable securities and restricted cash	$ 33,800
Accumulated deficit	472,216		$ 422,975
Stockholders' deficit	$ 12,903		$ (8,726)	$ 34,005
Debt maturity date	Dec. 30, 2022
Minimum price of common stock for continued listing		$ 1.00
Maximum [Member]
Nature Of Business [Line Items]
Stock trading price	$ 1.00
Minimum [Member]
Nature Of Business [Line Items]
Regain compliance by increasing the stock price	$ 1.00
Term Loan Agreement [Member] | CRG [Member]
Nature Of Business [Line Items]
Minimum cash balance	$ 5,000
Debt maturity date	Dec. 30, 2023