Quarterly Financial Data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2019

Quarterly Financial Information Disclosure [Abstract]

Schedule of quarterly financial information

	Year ended December 31, 2019
	(In thousands, except per share data)
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter
Revenue:
Product revenue	$	1,314		$	1,274		$	1,177		$	1,562
Research revenue		142			71			56			294
Contribution revenue		329			459			444			1,213
Total revenue	$	1,785		$	1,804		$	1,677		$	3,069
Costs and expenses:
Cost of product revenue		4,388			4,820			3,944			3,611
Research and development		3,901			4,048			4,098			4,279
Selling, general and administrative		7,055			6,722			5,981			7,546
Total costs and expenses		15,344			15,590			14,023			15,436
Loss from operations	$	(13,559	)	$	(13,786	)	$	(12,346	)	$	(12,367	)
Net loss	$	(15,147	)	$	(15,647	)	$	(14,171	)	$	(14,041	)
Per share data:
Net loss per common share—basic and diluted	$	(0.34	)	$	(0.35	)	$	(0.31	)	$	(0.29	)

	Year ended December 31, 2018
	(In thousands, except per share data)
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter
Revenue:
Product revenue	$	1,048		$	1,220		$	1,218		$	1,319
Research revenue		1,263			2,711			1,248			473
Total revenue	$	2,311		$	3,931		$	2,466		$	1,792
Costs and expenses:
Cost of product revenue		3,273			3,458			3,042			5,631
Research and development		4,718			3,749			2,725			3,297
Selling, general and administrative		5,755			7,611			5,873			6,458
Total costs and expenses		13,746			14,818			11,640			15,386
Loss from operations	$	(11,435	)	$	(10,887	)	$	(9,174	)	$	(13,594	)
Net loss	$	(12,913	)	$	(12,324	)	$	(10,767	)	$	(15,149	)
Per share data:
Net loss per common share—basic and diluted	$	(0.36	)	$	(0.32	)	$	(0.25	)	$	(0.34	)