Quarterly Financial Data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2016

Quarterly Financial Data (unaudited)

Schedule of quarterly financial information

	Year ended December 31, 2016
	(In thousands, except per share data)
	First Quarter		Second Quarter		Third Quarter		Fourth Quarter
Revenue:
Product revenue	$	437	$	151	$	580	$	579
Research revenue		659		839		504		331
Total revenue	$	1,096	$	990	$	1,084	$	910
Costs and expenses:
Cost of product revenue		1,026		1,781		1,894		2,171
Research and development		6,589		6,369		5,200		5,851
Selling, general and administrative		6,204		6,143		5,935		5,795
Total costs and expenses		13,819		14,293		13,029		13,817
Loss from operations	$	(12,723)	$	(13,303)	$	(11,945)	$	(12,907)
Net loss	$	(13,426)	$	(14,046)	$	(12,783)	$	(14,549)
Net loss applicable to common shareholders	$	(13,426)	$	(14,046)	$	(12,783)	$	(14,549)
Per share data:
Net loss per common share—basic and diluted	$	(0.55)	$	(0.58)	$	(0.51)	$	(0.48)
	Year ended December 31, 2015
	(In thousands, except per share data)
	First Quarter		Second Quarter		Third Quarter		Fourth Quarter
Revenue:
Product revenue	$	11	$	—	$	245	$	343
Research revenue		178		564		804		668
Total revenue	$	189	$	564	$	1,049	$	1,011
Costs and expenses:
Cost of product revenue		1		—		829		910
Research and development		5,869		6,651		6,204		6,638
Selling, general and administrative		4,468		4,437		5,181		5,008
Total costs and expenses		10,338		11,088		12,214		12,556
Loss from operations	$	(10,149)	$	(10,524)	$	(11,165)	$	(11,545)
Net loss	$	(10,619)	$	(10,995)	$	(11,644)	$	(12,032)
Net loss applicable to common shareholders	$	(10,619)	$	(10,995)	$	(11,644)	$	(12,032)
Per share data:
Net loss per common share—basic and diluted	$	(0.53)	$	(0.54)	$	(0.57)	$	(0.56)