X0306 4 2020-02-03 0 0001492674 T2 Biosystems, Inc. TTOO 0001615937 McDonough John 101 HARTWELL AVE LEXINGTON MA 02421 1 0 0 0 Common Stock 2020-02-03 4 S 0 23754 0.88 D 489114 D The transaction was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on June 11, 2018. The price reported is a weighted average price. These shares were sold in multiple transactions at per share prices ranging from $0.81 to $0.91. The reporting person undertakes to provide upon request to the SEC staff, the Issuer, or any stockholder of the Issuer, full information regarding the number of shares sold at each price within the range set forth in this footnote. /s/ John Sprague, Attorney-in-fact 2020-02-05