X0206 3 2016-09-21 0 0001492674 T2 Biosystems, Inc. TTOO 0001685215 CANON U.S.A., INC. ONE CANON PARK MELVILLE NY 11747 0 0 1 0 0000016988 CANON INC 30-2 SHIMOMARUKO, 3-CHOME OHTA-KU TOKYO M0 146-8501 JAPAN 0 0 1 0 Common Stock 6055341 D These shares are owned directly by Canon U.S.A., Inc., which is a wholly owned subsidiary of Canon Inc. Canon Inc. is an indirect beneficial owner of the reported securities. CANON U.S.A., INC.: /s/ Seymour Liebman, Executive Vice President, Chief Administrative Officer and General Counsel 2016-09-30 CANON INC.: /s/ Toshizo Tanaka, Executive Vice President and Chief Financial Officer 2016-09-30